Neural basis of tactile object perception in SI cortex
SI 皮层触觉物体感知的神经基础
基本信息
- 批准号:9270083
- 负责人:
- 金额:$ 57.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-05-15 至 2021-04-30
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAnimalsAreaBehaviorBehavioralBindingBrainCodeCortical ColumnDataData SetDevelopmentDigit structureDiscriminationElectrophysiology (science)EnvironmentEsthesiaExhibitsFailureFingersFoodFunctional Magnetic Resonance ImagingFutureGoalsHandImageInvestigationKnowledgeLasersLeadLiftingLinkLocationManualsMapsMeasurableMethodsModalityMonkeysMotionMotorNeuronsOpticsPatternPhysiologic pulsePositioning AttributePosturePrimary LesionPrimatesProsthesisResolutionRoleSensoryShapesSomatosensory CortexSpecificitySurfaceTactileTechniquesTestingTextTextureVisual system structureWeightWeight Perceptionawakebody languagebrain machine interfaceclinically relevantcortex mappingdesigngraspinformation processingneural circuitnonhuman primatenovelobject perceptionoptical imagingoptogeneticspublic health relevancerelating to nervous systemsensory integrationsomatosensorytool
项目摘要
DESCRIPTION (provided by applicant): The goal of this proposal is to investigate the organization and circuitry within the hand and digit region of primary somatosensory cortex in nonhuman primates. Hand and digit behavior are defining aspects of object identification in primate behavior, and are central to different types of tool use, typing, texting, and body language. Despite this, little is known regarding the cortical circuitry underlying different stage of sensory (tactile and proprioceptive) processing. This proposal will use multiple anatomical and functional approaches to discover the intra-areal and inter-areal connectivity patterns between functional columns in the hand representation of primary somatosensory areas (3a, 3b, 1, and 2). These approaches will include anatomical tract tracing and functional tract tracing (using optical imaging and fMRI during focal electrical and pulsed near infrared laser stimulation). The role of these circuits during behavior will be examined. These studies will provide invaluable data for incorporation of sensory guidance in manual motor prosthetics, an area in which there is currently little understanding.
描述(由申请人提供):本提案的目标是研究非人类灵长类动物初级体感皮层的手和手指区域内的组织和电路。手和手指行为是灵长类动物行为中物体识别的定义方面,并且是不同类型的工具使用,打字,发短信和肢体语言的核心。尽管如此,关于感觉(触觉和本体感受)处理的不同阶段的皮层回路知之甚少。该提案将使用多种解剖学和功能方法来发现初级躯体感觉区(3a,3b,1和2)的手部表示中功能柱之间的区域内和区域间连接模式。这些方法将包括解剖道追踪和功能道追踪(在局灶性电刺激和脉冲近红外激光刺激期间使用光学成像和功能磁共振成像)。这些电路在行为过程中的作用将被检查。这些研究将提供宝贵的数据,将感官指导纳入手动运动假肢,目前在这方面的了解很少。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert Mark Friedman其他文献
Permselective catalysis
- DOI:
10.1016/s0166-9834(00)84048-8 - 发表时间:
1984-01-01 - 期刊:
- 影响因子:
- 作者:
Robert Mark Friedman;David E. Gross;Arnold Hershman;Frank P. Jakse - 通讯作者:
Frank P. Jakse
Robert Mark Friedman的其他文献
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{{ truncateString('Robert Mark Friedman', 18)}}的其他基金
Wireless optical imaging, optogenetic stimulation and neurophysiological recording to study to neural foundations of natural freely moving behaviors in primates.
无线光学成像、光遗传学刺激和神经生理学记录,用于研究灵长类动物自然自由运动行为的神经基础。
- 批准号:
10260530 - 财政年份:2020
- 资助金额:
$ 57.89万 - 项目类别:
Wireless optical imaging, optogenetic stimulation and neurophysiological recording to study to neural foundations of natural freely moving behaviors in primates.
无线光学成像、光遗传学刺激和神经生理学记录,用于研究灵长类动物自然自由运动行为的神经基础。
- 批准号:
10056623 - 财政年份:2020
- 资助金额:
$ 57.89万 - 项目类别:
Neural basis of tactile object perception in SI cortex
SI 皮层触觉物体感知的神经基础
- 批准号:
9078506 - 财政年份:2016
- 资助金额:
$ 57.89万 - 项目类别:
Neural basis of tactile object perception in SI cortex
SI 皮层触觉物体感知的神经基础
- 批准号:
9914349 - 财政年份:2016
- 资助金额:
$ 57.89万 - 项目类别:
Optical Imaging of Tactile Information in S1 Cortex
S1 皮层触觉信息的光学成像
- 批准号:
8321671 - 财政年份:2003
- 资助金额:
$ 57.89万 - 项目类别:
Optical Imaging of Tactile Information in S1 Cortex
S1 皮层触觉信息的光学成像
- 批准号:
7912232 - 财政年份:2003
- 资助金额:
$ 57.89万 - 项目类别:
Optical Imaging of Tactile Information in S1 Cortex
S1 皮层触觉信息的光学成像
- 批准号:
7920893 - 财政年份:2003
- 资助金额:
$ 57.89万 - 项目类别:
Optical Imaging of Tactile Information in S1 Cortex
S1 皮层触觉信息的光学成像
- 批准号:
8318782 - 财政年份:2003
- 资助金额:
$ 57.89万 - 项目类别:
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