EXAFS STUDIES OF (LT) A4 HYDROLASE & ITS ENZYME INHIBITORS

白三烯（LT）A4水解酶（E.C. 3.3.2.6）是一种含Zn 金属酶，分类为胞质环氧化物水解酶。 它 催化LTA4转化为LTB4，LTB4是一种有效的促炎因子， 剂 这次调查的关键是要了解性质， 小分子抑制水解酶活性的机制 LTA4酶的目的是促进设计， 开发治疗炎症的药物。 虽然 氨基肽酶活性也被发现与这种蛋白质，其“天然” 基质尚未确定。

Leukotriene (LT) A4 hydrolase (E.C. 3.3.2.6) is a Zn-containing metalloenzyme classified as a cytosolic epoxide hydrolase. It catalyzes the conversion of LTA4 to LTB4, a potent pro-inflammatory agent. The crux of this investigation is to understand the nature and mechanism of small molecule inhibition of the hydrolase activity of the LTA4 enzyme with the objective to facilitate the design and development of pharmaceuticals to treat inflammation. Although aminopepidase activity was also found with this protein, its "natural" substrate has not been identified.