Optical Imaging of Tactile Information in S1 Cortex

描述(申请人提供)：这项提案的目标是研究大脑如何编码大脑中的触觉运动信息。将检查初级躯体感觉皮质(SI)不同区域(区域3a、3b、1和2)的反应。理解它们的功能角色的核心是找出一个领域与另一个领域的区别。通过使用简单刺激和复杂刺激，我们的目标是区分其反应与刺激的物理性质密切相关的区域和其反应不变且更接近地反映运动感知的区域。我们将使用光学成像、电压敏感染料成像、BOLD功能磁共振成像、单单元记录和解剖示踪方法来解决这些问题。这些实验将阐明触觉行为和注意力背后的神经回路，了解这将对中风后功能恢复和触觉假体的发展具有临床意义。与公共健康相关：这项提议的目标是研究大脑如何编码大脑中的触觉运动信息，特别是在初级躯体感觉皮质(SI)。这些研究将阐明触觉行为和注意力背后的神经回路，了解这对中风后功能恢复和触觉假体的发展具有临床意义。

Description (provided by applicant): The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain. Responses within different areas of primary somatosensory cortex (SI) will be examined (areas 3a, 3b, 1, and 2). Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics. PUBLIC HEALTH RELEVANCE: The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain, in particular in the primary somatosensory cortex (SI). These studies will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics.