Optical Imaging of Tactile Information in S1 Cortex

S1 皮层触觉信息的光学成像

• 批准号: 7912232
• 负责人: Robert Mark Friedman
• 金额: $ 6.5万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2010-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7912232
• 关键词: Address; Area; Attention; Behavior; Behavioral; Brain; Code; Complement; Complex; Cues; Data; Development; Digit structure; Discrimination; Dyes; Exhibits; Feedback; Functional Magnetic Resonance Imaging; Goals; Hand; Image; Length; Location; Maps; Mechanoreceptors; Methods; Monkeys; Motion; Motion Perception; Movement; Nature; Neurons; Parietal; Perception; Prosthesis; Psychophysiology; Recovery of Function; Resolution; Role; Signal Transduction; Skin; Somatosensory Cortex; Stimulus; Stroke; Structure; Surface; Tactile; Texture; Visual system structure; abstracting; awake; clinically relevant; human subject; imaging modality; neural circuit; object motion; object shape; optical imaging; receptor; research study; response; spatiotemporal; ventral intraparietal area; voltage

ABSTRACT The goal of this proposal is to investigate how the brain encodes tactile motion information in the brain. Responses within different areas of primary somatosensory cortex (SI) will be examined (areas 3a, 3b, 1, and 2). Central to understanding their functional roles is finding out what distinguishes one area from another. By using simple versus complex stimuli, we aim to distinguish between areas whose responses are closely associated with the physical nature of the stimulus and areas whose responses are invariant and more closely reflect the motion percept. We will employ optical imaging, voltage sensitive dye imaging, BOLD fMRI, single unit recording, and anatomical tracing methods to address these questions. These experiments will elucidate the neural circuitries underlying tactile behavior and attention, understanding that will have clinical relevance for recovery of function from stroke and development of tactile prosthetics. 2

抽象的 该提案的目标是研究大脑如何编码触觉运动信息 大脑。将检查初级体感皮层 (SI) 不同区域的反应 （区域 3a、3b、1 和 2）。了解他们的职能角色的核心是找出他们的区别 一个区域与另一个区域。通过使用简单与复杂的刺激，我们的目标是区分区域 其反应与刺激的物理性质和其区域密切相关 响应是不变的并且更接近地反映运动感知。我们将采用光学成像， 电压敏感染料成像、BOLD fMRI、单个单元记录和解剖追踪方法 解决这些问题。这些实验将阐明触觉背后的神经回路 行为和注意力，以及对功能恢复具有临床相关性的理解 中风和触觉假肢的发展。 2