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EXAFS STUDIES OF (LT) A4 HYDROLASE & ITS ENZYME INHIBITORS

EXAFS STUDIES OF (LT) A4 HYDROLASE & ITS ENZYME INHIBITORS
(LT) A4 水解酶的 EXAFS 研究
批准号：
6437604
负责人：
Robert Mark Friedman
金额：
$14.32万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-03-01 至 2002-02-28
来源：
https://reporter.nih.gov/project-details/6437604
关键词：
biomaterials biomedical resource enzymes spectrometry structural biology

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英文摘要
Leukotriene (LT) A4 hydrolase (E.C. 3.3.2.6) is a Zn-containing metalloenzyme classified as a cytosolic epoxide hydrolase. It catalyzes the conversion of LTA4 to LTB4, a potent pro-inflammatory agent. The crux of this investigation is to understand the nature and mechanism of small molecule inhibition of the hydrolase activity of the LTA4 enzyme with the objective to facilitate the design and development of pharmaceuticals to treat inflammation. Although aminopepidase activity was also found with this protein, its "natural" substrate has not been identified.
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