6th EU-US Conference on Repair of Endogenous DNA Damage

项目总结/摘要 第六届美国-欧盟内源性DNA损伤修复会议将于2017年9月24日至28日在 乌迪内，意大利。这一系列会议的独特之处在于它关注的是自然形成的细胞反应， 基因组损伤，以及这些反应中的缺陷与遗传遗传性疾病相关的关系， 癌症易感性，神经缺陷和过早衰老了解的贡献 内源性DNA损伤对人类疾病，特别是癌症的影响，以及与之相关的病理变化 老龄化确实是这次会议的主题。最近，有一个爆炸式的增长， 癌症基因组信息;基因组编辑新技术的发展;可视化DNA 修复复合物; RNA在基因组稳定性中的作用; DNA修复和表观遗传学的新机制;以及 衰老和环境暴露在基因组稳定性中的作用。这次会议的一个主要目标是促进 对影响癌症基因组不稳定性的细胞过程的合作研究。内源性的作用 DNA损伤，特别是氧化性DNA损伤，作为正常和加速衰老的驱动因素，以及对DNA损伤的研究 过早老化综合征仍然是重要的研究领域。从罕见的遗传性人类疾病的见解， DNA损伤反应的缺陷继续阐明内源性DNA损伤和癌症之间的联系， 衰老和神经系统疾病。促进翻译知识的来源和修复， 将内源性DNA损伤转化为改善全球人类健康的干预措施，本次会议将刺激 合作转化研究的重点是确定新的治疗靶点和发展 的治疗策略，要么调节DNA修复途径，以加强癌症治疗，或延迟 神经变性，或减少与衰老相关的病理变化。2017年的一个关键目标 会议旨在为不同背景的早期职业和高级调查人员提供一个环境， 交流他们在相关科学主题上的最新成果，并建立互动，不仅加强 在这一竞技场上的众多基础科学和转化研究工作，也促进了 下一代的研究人员。会议将在乌迪内大学举行，选择这个地点是因为 它在欧洲中心提供了一个独特的非正式互动环境。这个位置将最大限度地提高互动 在参与者中，确保促进美国科学家之间富有成效的互动的目标， 欧盟（EU）实现。

Project Summary / Abstract The 6th US-EU Conference on Repair of Endogenous DNA Damage will be held September 24-28, 2017 in Udine, Italy. The uniqueness of this series of meetings is its focus on the cellular responses to naturally formed genomic damage, and the relationship of defects in these responses to genetically inherited disorders associated with cancer predisposition, neurological deficits and premature aging. Understanding the contributions of endogenous DNA damage to human disease, in particular cancer, and the pathological changes associated with aging is indeed the major theme of this conference. Recently, there has been an explosion-like increase of information on cancer genomes; the development of novel technologies for genome editing; visualizing DNA repair complexes; the role for RNA in genome stability; novel mechanisms of DNA repair and epigenetics; and the role of aging and environmental exposures in genome stability. A major goal of this meeting is to foster collaborative research on the cellular processes that affect genomic instability in cancer. The role of endogenous DNA damage, in particular oxidative DNA damage, as a driver of normal and accelerated aging and the study of premature aging syndromes remain important areas of interest. Insights from rare inherited human diseases with defects in the DNA damage response continue to illuminate links between endogenous DNA damage and cancer, aging and neurologic disease. To promote the translation of knowledge about the sources and repair of endogenous DNA lesions into interventions that improve global human health, this meeting will stimulate collaborative translational research focused on the identification of new therapeutic targets and the development of treatment strategies that either regulate DNA repair pathways in order to enhance cancer treatment, or delay neurodegeneration, or reduce the pathological changes associated with aging. A key objective of the 2017 meeting is to provide an environment for both early career and senior investigators of diverse backgrounds to communicate their latest results on relevant scientific topics and establish interactions that will not only strengthen the numerous basic science and translational research efforts in this arena, but also enhance the development of the next generation of researchers. The meeting will be held at the University of Udine, a venue chosen because it offers a unique informal interactive environment in the center of Europe. This location will maximize interactions amongst participants, ensuring that the goal of promoting productive interactions between scientists in the US and the European Union (EU) is achieved.