Annual Midwest DNA Repair Symposium

描述(由申请人提供) 环境暴露有助于人类疾病的发展和进展，包括癌症、心血管疾病和神经退化。对环境暴露的细胞和分子影响的详细研究提供了对疾病病因的洞察，以及识别易患环境相关疾病的人类。许多环境暴露会导致DNA损伤，并会影响DNA修复、损伤耐受性和/或细胞对DNA损伤的反应，导致DNA损伤、突变、染色体异常或细胞死亡。因此，确定促进遗传毒性应激的环境暴露，并了解细胞如何对DNA损伤做出反应，对于了解癌症和包括衰老在内的退行性疾病至关重要。 一年一度的中西部DNA修复研讨会(AMDRS)提供了一个定期论坛，讨论专注于DNA损伤和修复的基础和应用研究，因为它与人类遗传病、环境暴露、癌症和老龄化有关。第十届AMDRS将汇聚美国中西部各州的科学家，目的是加强合作，传播有关DNA修复机制及其对环境造成的DNA损伤和人类疾病的影响的现有知识。指导这次研讨会的基本目标是1999年在密歇根州安娜堡举行的第一次会议上确定的。AMDRS的三个具体目标是：(1)为主要来自中西部各州的科学家提供一个介绍和讨论该领域当前研究的场所；(2)为学生、博士后研究员和初级独立研究人员提供向同行介绍他们的工作并与该领域的领导者互动的机会；以及(3)加强研究人员之间的互动并促进合作，以解决环境引起的DNA损伤及其对人类疾病的影响领域的重要问题。 创新想法和新颖观察的汇集及其在亲密环境中的传播预计将促进该领域研究人员之间的有意义的相互交流，从而导致抗击疾病的合理战略。AMDRS的第二个重要目的是为研究生和博士后研究员提供一个论坛，介绍他们的工作，并与研究环境暴露造成的DNA损伤修复的高素质科学家密切互动。讨论的主题将包括调节对遗传毒性应激反应的基因-环境相互作用，DNA损伤对人类细胞的影响，以及开发研究基因组不稳定综合征的模型系统。在过去的九年里，AMDRS提供了一个非常经济和有效的科学论坛，促进了互动，建立了新的合作，并帮助吸引年轻的研究人员投身环境健康科学的职业。

DESCRIPTION (provided by applicant) Environmental exposures contribute to the development and progression of human disease, including cancer, cardiovascular disease and neurodegeneration. Detailed study of the cellular and molecular impact of environmental exposures provides insight into disease etiology as well as identifying humans predisposed to environment related disease. Many environmental exposures induce DNA damage and can impact DNA repair, damage tolerance and/or cellular responses to DNA damage, leading to the accumulation of DNA lesions, mutations, chromosomal aberrations or cell death. Therefore identifying environmental exposures that promote genotoxic stress and understanding how cells respond to DNA damage is critical for understanding cancer and degenerative diseases including aging. The Annual Midwest DNA Repair Symposium (AMDRS) provides a regular forum for deliberating basic and applied research focused on DNA damage and repair as it relates to human genetic diseases, environmental exposures, cancer and aging. The 10th AMDRS will bring together scientists from the U.S. Midwestern States with the goal of enhancing collaborations and disseminating current knowledge about the mechanisms of DNA repair and their influence on environmentally induced DNA damage and human disease. The basic objectives guiding the conduct of this symposium were established in 1999 at the first meeting in Ann Arbor, MI. The three specific aims of the AMDRS are: (1) to provide a venue for scientists, from principally Midwestern states, to present and discuss the current research in the field; (2) to provide students, postdoctoral fellows and junior independent investigators the opportunity to present their work to peers and interact with leaders in the field, and (3) to enhance interactions between researchers and foster collaborations to address important issues in the field of environmentally induced DNA damage and its impact on human disease. A congregation of innovative ideas and novel observations and their dissemination in an intimate setting is anticipated to promote meaningful cross talk amongst researchers in the field leading to rational strategies for combating disease. A second important purpose served by AMDRS is to provide a forum for graduate students and postdoctoral fellows to present their work and interact closely with high caliber scientists studying the repair of DNA damage caused by environmental exposures. Topics of discussion will include gene-environment interactions that modulate responses to genotoxic stress, the impact of DNA damage on human cells and developing model systems to study genome instability syndromes. The AMDRS has provided a very economical and effective scientific forum for the past nine years, fostering interactions, forging new collaborations and helping to attract young investigators to careers in environmental health sciences.