1/2: Partnership to study racial/ethnic differences in GI cancer biology

1/2：合作研究胃肠道癌症生物学中的种族/民族差异

• 批准号: 9332092
• 负责人: ELLEN LI
• 金额: $ 28.89万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-23 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9332092
• 关键词: 3-Dimensional; Address; African; African American; Applications Grants; Area; Awareness; Basic Science; Bioinformatics; Biological; Biological Markers; Biology; Biomedical Research; Cancer Biology; Cancer Patient; Cancer Research Project; Cancer Science; Caucasians; Clinical; Clinical Data; Clinical Research; Code; Collection; Colon Carcinoma; Colorectal; Communication; Communities; Community Health Education; Community Outreach; Companions; Computational Science; Consensus; Controlled Vocabulary; Core Biopsy; DNA; Data; Data Element; Data Set; Decision Making; Detection; Development Plans; Dimensions; Disease; Drug Targeting; Education; Emerging Technologies; Evolution; Exhibits; Faculty; Genetic; Genomics; Goals; Grant; Healthcare; Histologic; Histology; Human; In Vitro; Incidence; Individual; Institution; Knowledge; Laboratories; Link; Malignant Neoplasms; Malignant neoplasm of pancreas; Maps; Medical; Medical center; Mentors; Mentorship; Metadata; Methods; Methylation; Molecular; Molecular Abnormality; Molecular Analysis; Molecular and Cellular Biology; NCI Scholars Program; NCI-Designated Cancer Center; Organoids; Outcome; Pancreas; Pancreatic duct; Patients; Population; Procedures; Proteins; RNA; Research; Research Personnel; Research Project Grants; Resources; Sampling; Science; Specimen; Stem cells; Student recruitment; Students; Technology; Testing; Tissues; Training; Training and Education; Translational Research; Tumor-Derived; Ultrasonography; Underrepresented Minority; Underrepresented Students; Universities; Unresectable; Vocabulary; anticancer research; base; biobank; biomedical informatics; cancer care; cancer health disparity; care delivery; career development; certificate program; chemotherapy; cultural competence; demographics; design; disease heterogeneity; doctoral student; epigenetic profiling; epigenomics; ethnic difference; ethnic minority population; experience; faculty research; genomic profiles; graduate medical education; graduate student; health disparity; high dimensionality; high risk; histological image; improved; individual patient; innovation; interest; medically underserved; minority communities; mortality; novel; outreach program; programs; public health relevance; racial and ethnic; racial difference; racial minority; screening; success; surgery material; symposium; translational medicine; translational study; tumor

DESCRIPTION (provided by applicant): ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of bio specimens and linked high dimensional 'omic datasets generated from these bio specimens. In this planning grant we plan to develop a SUNY Downstate GI BioBank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the bio specimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of bio specimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson's laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.

描述（由申请人提供）：摘要纽约州立大学的两个医学校区（纽约州立大学石溪分校和纽约州立大学下州分校）为存在癌症健康差异的少数族裔社区提供服务，正在与 NCI 指定的冷泉港实验室癌症中心合作，评估胃肠道癌症（结直肠癌和胰腺癌）的生物学和遗传差异，这些差异可能与在种族和族裔中观察到的癌症发病率和结果的差异有关 （URM）。对于癌症研究计划，我们的目标是在生物样本收集和从这些生物样本生成的链接高维组学数据集中增强代表性不足的少数群体的代表性。在这笔规划拨款中，我们计划开发一个纽约州立大学下州 GI 生物库，该生物库与纽约州立大学石溪分校 GI 生物库并行运行，使用标准操作程序。我们正在计划开发一个综合生物医学信息学平台，将生物样本与纵向临床数据以及这些样本生成的数据联系起来。规划过程的第一步是就要包含哪些数据元素以及开发受控词汇达成共识。为了增加种族和少数族裔人口的社区参与性研究，我们计划利用纽约州立大学布鲁克林下州健康差异中心（由 Moro Salifu 博士领导）的资源和专业知识，在少数族裔比例较高的服务不足社区制定社区教育和外展计划。生物标本的收集将由两个试点研究项目 P1 和 P2 驱动。在 P1 中，我们建议比较 URM 结肠癌和非 URM 结肠癌的基因组和表观遗传学分析。在 P2 中，我们建议测试采用创新的 3D 方法从祖细胞（由 CSHL Tuveson 博士的实验室开发）中培养胰腺类器官（微型胰腺）的可行性，这些祖细胞是从纽约州立大学两个医学院采集的人类胰腺癌的细针核心活检中提取的。我们计划将 URM 胰腺类器官与非 URM 类器官的基因组和表观基因组分析进行比较。对于培训和教育计划，我们致力于提高代表性不足的少数群体对生物医学研究的参与，并提高现有癌症研究人员对健康差异的认识。在这项规划拨款中，纽约州立大学的两个医学院将与 CSHL 合作创建一个综合博士证书项目“癌症健康差异生物医学科学学者”。该项目旨在让博士生参与转化医学，特别是癌症健康差异方面的研究，通过促进这些学生了解与其论文研究领域相关的疾病的表现、进展和治疗。该课程需要在通常的学生基础科学顾问团队中增加一名临床共同导师，帮助指导学生的生物医学/临床研究，并使学生沉浸在临床经验、词汇和临床研究的整体文化中。