Administrative Core

行政核心

基本信息

批准号：
9038105
负责人：
ELLEN LI
金额：
$ 11.78万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-23 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9038105
关键词：
3-Dimensional Address Advisory Committees Affect African African American Archives Area Award Awareness Basic Science Biological Biomedical Research Blood Cancer Biology Cancer Center Cancer Center at Cold Spring Harbor Laboratory Cancer Research Project Clinical Clinical Data Clinical Research Collection Colon Carcinoma Colorectal Cancer Communities Community Health Education Community Outreach Computational Science Confounding Factors (Epidemiology)Consensus Controlled Vocabulary Core Biopsy Data Data Element Data Set Development Development Plans Disease Education Emerging Technologies Exhibits Faculty Feces Funding Future Genetic Genomics Goals Grant Health Insurance Health Services Accessibility Human Incidence Individual Institution Job Satisfaction Knowledge Laboratories Link Malignant Neoplasms Malignant neoplasm of pancreas Measures Medical Mentors Mentorship Metadata Methods Minority Groups Molecular Molecular and Cellular Biology Monitor NCI Scholars Program NCI-Designated Cancer Center Organoids Outcome Pancreas Performance Pilot Projects Population Procedures Research Research Personnel Research Project Grants Resource Sharing Resources Sampling Science Specimen Stem cells Students Technology Testing Tissues Training Training and Education Translational Research Underrepresented Minority Vocabulary Work anticancer research base biobank biomedical informatics cancer care cancer health disparity care delivery demographics design doctoral student epigenetic profiling epigenomics ethnic minority population experience graduate medical education graduate student health disparity high risk improved innovation interest mortality outreach program patient population programs racial and ethnic racial/ethnic difference success symposium translational medicine

项目摘要

ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratory (CSHL) to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of biospecimens and linked high dimensional ‘omic datasets generated from these biospecimens. In this planning grant we plan to develop a SUNY Downstate GI Biobank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the biospecimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of biospecimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson’s laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program, Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.

抽象的两个纽约州立医疗校园（SUNY Stony Brook和Suny Downstate）服务不足的少数民族具有癌症健康分布的社区正在与寒冷的NCI指定癌症中心合作春港实验室（CSHL）评估GI癌的生物学和遗传差异（结直肠癌和胰腺可能与种族和种族中观察到的癌症发病率和结果的差异有关少数民族（URM）。对于癌症研究计划，我们旨在增加代表性不足的少数群体在收集生物测量和链接的高维度数据集中由这些生物测量产生。在这项计划赠款中，我们计划开发一个SUNY Downstate GI BioBank 使用标准操作程序与SUNY Stony Brook Gi Biobane并行运行。我们是计划开发一个综合生物医学信息平台，该平台将将生物测量联系起来纵向临床数据以及这些标本产生的数据。计划的第一步程序是为了制定包含哪些数据元素和受控词汇的共识。到增加种族和少数民族人口的社区参与研究，我们计划利用 SUNY Downstate Brooklyn健康差异中心的资源和专业知识（由Moro Salifu博士领导）在高比例的服务不足的社区中开发社区教育和外展计划种族和少数民族。生物测量的收集将由两个试点研究项目驱动，P1 和P2。在P1中，我们建议将URM结肠癌的基因组和表观遗传分析与非URM进行比较结肠癌。在P2中，我们建议测试适应创新的3-D方法的可行性祖细胞的胰腺器官（微型胰腺）（在图维森博士的实验室中开发 CSHL）来自在两个SUNY Medical收集的人类胰腺癌的细针核活检校园。我们计划比较URM胰腺器官的基因组和表观基因组分析非纯净的类器官。对于培训和教育计划，我们致力于改善代表性不足的少数群体参与生物医学研究并提高了对健康的认识既定的癌症研究人员之间的差异。在这个计划中，两个纽约州立大学的医疗校园将与CSHL合作，创建一项综合博士证书计划，即生物医学学者癌症健康差异。该计划旨在让博士生参与转化医学，特别是在癌症健康分布中，通过促进这些学生的理解，与其论文研究领域有关的疾病的进展和治疗。曲目需要加法通常的学生基础科学顾问团队的临床副主管，他们将帮助指导学生的生物医学/临床研究并将学生浸入临床经验，词汇和整体上临床研究文化。