1/2: Partnership to study racial/ethnic differences in GI cancer biology

描述（申请人提供）：纽约州立大学两个医学院（纽约州立大学斯托尼布鲁克和纽约州立大学下州分校）服务于代表性不足的少数民族社区与癌症健康的差距是与国家癌症研究所指定的癌症中心在冷泉港实验室，以评估生物和遗传差异的胃肠道癌症（结肠直肠和胰腺），可能与在种族和少数民族（URM）中观察到的癌症发病率和结局差异有关。对于癌症研究计划，我们的目标是增加代表性不足的少数民族在生物标本的收集和链接从这些生物标本生成的高维'omic数据集的代表性。在这项规划拨款中，我们计划开发一个与纽约州立大学斯托尼布鲁克GI生物银行平行运作的纽约州立大学下州GI生物银行，使用标准操作程序。我们正在计划开发一个综合生物医学信息学平台，将生物标本与纵向临床数据以及从这些标本生成的数据联系起来。规划过程的第一步是就包括哪些数据元素以及开发受控词汇表达成共识。为了增加种族和少数民族人口中的社区参与性研究，我们计划利用纽约州立大学布鲁克林健康差异中心（由摩罗萨利夫博士领导）的资源和专业知识，在少数民族和少数民族比例较高的服务不足社区开展社区教育和外展计划。生物标本的收集将由两个试点研究项目P1和P2驱动。在P1中，我们建议比较URM结肠癌与非URM结肠癌的基因组和表观遗传学特征。在P2中，我们建议测试采用创新的3D方法从祖细胞（在CSHL的Tuveson博士实验室开发）中生长胰腺类器官（微型胰腺）的可行性，这些祖细胞来自两个SUNY医学院收集的人类胰腺癌细针芯活检。我们计划比较URM胰腺类器官与非URM类器官的基因组和表观基因组图谱。对于培训和教育计划，我们致力于改善代表性不足的少数民族在生物医学研究中的参与，并提高对癌症研究人员健康差异的认识。在这项规划拨款中，两个SUNY医学院将与CSHL合作，创建一个综合博士证书课程，即癌症健康差异生物医学科学学者。该计划旨在让博士生参与转化医学，特别是癌症健康差异，通过促进这些学生对与他们的论文研究领域相关的疾病的介绍，进展和治疗的理解。该课程要求在通常的学生基础科学顾问团队中增加一名临床共同导师，他们将帮助指导学生的生物医学/临床研究，并使学生沉浸在临床经验，词汇和临床研究的整体文化中。

DESCRIPTION (provided by applicant): ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of bio specimens and linked high dimensional 'omic datasets generated from these bio specimens. In this planning grant we plan to develop a SUNY Downstate GI BioBank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the bio specimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of bio specimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson's laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.