1/2: Partnership to study racial/ethnic differences in GI cancer biology

1/2：合作研究胃肠道癌症生物学中的种族/民族差异

基本信息

批准号：
9379097
负责人：
ELLEN LI
金额：
$ 6.31万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-23 至 2019-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9379097
关键词：
3-Dimensional Address African African American Applications Grants Area Awareness Basic Science Bioinformatics Biological Biological Markers Biology Biomedical Research Cancer Biology Cancer Patient Cancer Research Project Cancer Science Caucasians Clinical Clinical Data Clinical Research Code Collection Colon Carcinoma Colorectal Communication Communities Community Health Education Community Outreach Companions Computational Science Consensus Controlled Vocabulary Core Biopsy DNA Data Data Element Data Set Decision Making Detection Development Plans Dimensions Disease Drug Targeting Education Emerging Technologies Evolution Exhibits Faculty Genetic Genomics Goals Grant Healthcare Histologic Histology Human In Vitro Incidence Individual Institution Knowledge Laboratories Link Malignant Neoplasms Malignant neoplasm of pancreas Maps Medical Medical center Mentors Mentorship Metadata Methods Methylation Molecular Molecular Abnormality Molecular Analysis Molecular and Cellular Biology NCI Scholars Program NCI-Designated Cancer Center Organoids Outcome Pancreas Pancreatic duct Patients Population Procedures Proteins RNA Research Research Personnel Research Project Grants Resources Sampling Science Specimen Stem cells Student recruitment Students Technology Testing Tissues Training Training and Education Translational Research Tumor-Derived Ultrasonography Underrepresented Minority Underrepresented Students Universities Unresectable Vocabulary anticancer research base biobank biomedical informatics cancer care cancer health disparity care delivery career development certificate program chemotherapy cultural competence demographics design disease heterogeneity doctoral student epigenetic profiling epigenomics ethnic difference ethnic minority population experience faculty research genomic profiles graduate medical education graduate student health disparity high dimensionality high risk histological image improved individual patient innovation interest medically underserved minority communities mortality novel outreach program programs public health relevance racial and ethnic racial difference racial minority screening success surgery material symposium translational medicine translational study tumor

项目摘要

DESCRIPTION (provided by applicant): ABSTRACT Two SUNY medical campuses (SUNY Stony Brook and SUNY Downstate) serving underrepresented minority communities with cancer health disparities are partnering with the NCI designated Cancer Center at the Cold Spring Harbor Laboratories to evaluate biological and genetic differences in GI cancers (colorectal and pancreatic) that may link to differences in cancer incidence and outcome observed in racial and ethnic minorities (URM). For the Cancer Research Program, we aim to augment the representation of underrepresented minorities in the collection of bio specimens and linked high dimensional 'omic datasets generated from these bio specimens. In this planning grant we plan to develop a SUNY Downstate GI BioBank that operates in parallel to the SUNY Stony Brook GI BioBank using standard operating procedures. We are planning the development of an integrative biomedical informatics platform that will link the bio specimens with longitudinal clinical data and with the data generated from these specimens. An initial step in the planning procedure is to develop a consensus of what data elements to include and for developing a controlled vocabulary. To increase community participatory research among racial and ethnic minority populations, we plan to leverage the resources and expertise of the SUNY Downstate Brooklyn Health Disparities Center(led by Dr. Moro Salifu) in developing community education and outreach programs in underserved communities with a high proportion of racial and ethnic minorities. The collection of bio specimens will be driven by two pilot research projects, P1 and P2. In P1, we propose to compare genomic and epigenetic profiling of URM colon cancers with non URM colon cancers. In P2, we propose to test the feasibility of adapting an innovative 3-D method to grow pancreatic organoids (miniature pancreas) from progenitor cells (developed in Dr. Tuveson's laboratory at CSHL) from fine needle core biopsies of human pancreatic cancers collected at the two SUNY medical campuses. We plan to compare genomic and epigenomic profiling of URM pancreatic organoids with those of non-URM organoids. For the Training and Education Program, we are committed to improving the participation of underrepresented minorities in biomedical research and in increasing awareness of health disparities among established cancer researchers. In this planning grant the two SUNY medical campuses will partner with CSHL to create an integrated doctoral certificate program Scholars in BioMedical Sciences in Cancer Health Disparities. This program is designed to engage doctoral students in translational medicine, particularly in cancer health disparities, by promoting in these students an understanding of the presentation, progression and treatment of diseases related to their area of thesis research. The track requires the addition of a clinical co-mentor to the usual student-basic science advisor team who will help guide the student's biomedical/clinical research and immerse the student in clinical experiences, vocabulary, and the overall culture of clinical research.

描述（由申请人提供）：摘要两个SUNY医疗校园（Suny Stony Brook和Suny Downstate）为代表性不足的少数民族社区提供癌症健康差异的服务与Cold Spring Harbour Laboratories的NCI指定的癌症中心合作，以评估GI CANCERS（癌症和术语）的生物学差异（可能是癌症差异），以至于癌症的差异可能是链接的，以至于癌症差异链接到癌症差异，以至于癌症差异是癌症的生动性，以至于癌症的生动型疾病，以弥补癌症的生动至关重要。（URM）。对于癌症研究计划，我们旨在扩大代表不足的少数群体在收集的生物标本中，并连接了这些生物标本产生的高维度数据集。在这项计划赠款中，我们计划开发一个与SUNY Stony Brook Gi Biobare Biobands并行运营的SUNY Downstate GI生物库，使用标准操作程序。我们正在计划开发一个综合生物医学信息学平台，该平台将将生物标本与纵向临床数据以及这些标本产生的数据联系起来。计划程序的第一步是建立一个共识，即要包含哪些数据元素并开发受控词汇。为了增加种族和少数民族人口之间的社区参与研究，我们计划利用纽约州立大学布鲁克林健康差异中心（由Moro Salifu博士领导）的资源和专业知识，以在具有很高的种族和族裔少数民族的高比例的社区中开发社区教育和外展计划中。生物标本的收集将由两个试点研究项目P1和P2驱动。在P1中，我们建议将URM结肠癌的基因组和表观遗传分析与非URM结肠癌进行比较。在P2中，我们建议测试从祖细胞（在CSHL博士的Tuveson's Laboratory中开发的胰腺器官（微型胰腺），从细针核心活检中，在两个Suny Medical Medical Campuses收集的人类胰腺癌症中，从祖细胞开发的胰腺器官（微型胰腺）。我们计划将URM胰腺器官的基因组和表观基因组分析与非纯净类器官的基因组分析。对于培训和教育计划，我们致力于改善代表性不足的少数群体参与生物医学研究，并提高既定癌症研究人员对健康差异的认识。在这项计划中，两个纽约州立大学的医疗校园将与CSHL合作，创建综合的博士证书课程在癌症健康差异方面的生物医学科学学者。该计划旨在通过在这些学生中促进这些学生对与其论文研究领域相关的疾病的表现，进步和治疗来促进这些学生的转化医学，特别是在癌症健康差异方面。该曲目需要向通常的学生基础科学顾问团队增加临床联合学者，他们将帮助指导学生的生物医学/临床研究，并将学生沉浸于临床经验，词汇和临床研究的整体文化中。