Cortical control over area-specific thalamic input
皮层对特定区域丘脑输入的控制
基本信息
- 批准号:9300013
- 负责人:
- 金额:$ 8.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-03-01 至 2019-02-28
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAreaAttentionAxonBrainBrain DiseasesBrain InjuriesCell NucleusCellsCerebral cortexColorCore FacilityCuesDevelopmentDistantEmbryoFaceFibroblast Growth Factor 8FluorescenceGoalsGrowthHumanIndividualInjection of therapeutic agentInjuryLabelLaboratoriesMapsMediatingMemoryMethodsMicroscopeMolecularMovementMusNatural regenerationNeocortexOutcomePerceptionPositioning AttributePrimordiumReportingResearchRetinaRodentRouteSensorySignal TransductionSliceStrokeStructureSurfaceTestingThalamic NucleiThalamic structureTimeTracerTransgenic MiceTravelVibrissaeViral VectorWorkbarrel cortexbasecortex mappingdesigndevelopmental neurobiologydigitalexperimental studymorphogensneocorticalnerve supplypostnatalpreventsomatosensorystatisticstranscription factor
项目摘要
PROJECT SUMMARY/ABSTRACT
Sensory thalamic nuclei relay information from sensory surfaces such as the retina and the vibrissae on
rodent's face to the cerebral cortex, connecting the cortex with the outside world. In turn primary sensory
areas of neocortex project to sequentially connected higher order neocortical areas that mediate such
functions as perception, memory and movement control. Knowing the mechanisms that direct
thalamocortical axons to the correct neocortical target is therefore important for understanding the
development of brain function, and aspects of abnormal development underlying human brain disorders.
Although an abundance of studies has uncovered many cellular and molecular signals that control the
growth of thalamic axons through subcortical structures, as well as how axons are precisely sorted along
their route, little attention has been paid to guidance signals inside the cortex itself. Yet substantial
evidence indicates that intra-cortical cues exist. The proposed work will utilize a mouse line in which
axons from sensory thalamic nuclei have been genetically labeled with fluorescence. This creates a
visible map of sensory areas on the surface of the brain. The neocortical area map will be altered in
these mice by manipulating the neocortical morphogen Fibroblast Growth Factor 8 (FGF8), which will
shift and duplicate sensory areas. Axonal tracers will be placed in different parts of the altered area
map, using the fluorescent map to identify the desired targets. After the tracer has had time to travel
from cortex to thalamus, the brain will be fixed and sectioned. The trajectories of labeled thalamocortical
axons will be viewed and reconstructed in 3D using a confocal microscope. These trajectories will shift
dramatically at points of normal thalamic guidance in the cortex because the cortical map itself has been
disrupted. The study will test the hypothesis that positional cues for thalamic axons are present in the
cortical subplate and in layer 4, the major recipient of thalamic input, and will be a preface to
investigating the molecular identity of such cues.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
ELIZABETH Elizabeth Grove其他文献
ELIZABETH Elizabeth Grove的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('ELIZABETH Elizabeth Grove', 18)}}的其他基金
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
9280998 - 财政年份:2014
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
8890239 - 财政年份:2014
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
9110331 - 财政年份:2014
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
8066238 - 财政年份:2010
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
7928673 - 财政年份:2009
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
7808067 - 财政年份:2007
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
7406112 - 财政年份:2007
- 资助金额:
$ 8.08万 - 项目类别:
Molecular Mechanisms of Cerebral Cortical Patterning
大脑皮层模式的分子机制
- 批准号:
7603009 - 财政年份:2007
- 资助金额:
$ 8.08万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Holocene Landscape History in the forest area „Schweinert“ – a geoarchaeological study in Germany’s largest Bronze Age barrow cemetery
森林地区全新世景观历史“Schweinert”——德国最大的青铜时代手推墓地的地质考古研究
- 批准号:
452251818 - 财政年份:2020
- 资助金额:
$ 8.08万 - 项目类别:
Research Grants
Empirical study on the Iron Production of the Early Iron Age in the Area of Altai Extending over Four Countries
阿尔泰地区四国早期铁器时代铁矿生产实证研究
- 批准号:
17H01646 - 财政年份:2017
- 资助金额:
$ 8.08万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Religious Paracelsianism: Science and Religion in the German-speaking Area of the Early Modern Age
宗教帕拉塞尔西主义:近代早期德语区的科学与宗教
- 批准号:
16K21332 - 财政年份:2016
- 资助金额:
$ 8.08万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Age and significance of permafrost landforms in the Fort McMurray area
麦克默里堡地区多年冻土地貌的年龄和意义
- 批准号:
478568-2015 - 财政年份:2015
- 资助金额:
$ 8.08万 - 项目类别:
University Undergraduate Student Research Awards
Late Neolithic/Early Bronze Age developments in the south-west Baltic area (2500-1500 BC): Why did the Bruszczewo-Leki Male type of power structures appear?
波罗的海西南部地区新石器时代晚期/青铜时代早期的发展(公元前2500-1500年):为什么会出现布鲁什切沃-莱基男性类型的权力结构?
- 批准号:
277223019 - 财政年份:2015
- 资助金额:
$ 8.08万 - 项目类别:
Research Grants
'Ritual feasting' in the Late Bronze Age in the northwestern Carpathian area -archaeological and scientific aspects
喀尔巴阡山脉西北部地区青铜时代晚期的“仪式盛宴”——考古和科学方面
- 批准号:
287419687 - 财政年份:2015
- 资助金额:
$ 8.08万 - 项目类别:
Research Grants
Research on the Folk House of Yeosu Area in a Modern Age -Consideration from a Viewpoint of the Influence of the Ocean Culture Area-
近代丽水地区民居研究-从海洋文化区影响的角度思考-
- 批准号:
26420607 - 财政年份:2014
- 资助金额:
$ 8.08万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study about the age and the production area of the Yan Guo and Liaoning Area Remains in the Spring and Autumn Warring States Period
春秋战国时期燕国及辽宁地区遗存的年代及产地研究
- 批准号:
25300043 - 财政年份:2013
- 资助金额:
$ 8.08万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The formation process of Tai Hang mountains area in Final stage of Chinese Neolithic age : Focused on analysing pottery
中国新石器时代末期大坑山区的形成过程——以陶器为重点分析
- 批准号:
23820059 - 财政年份:2011
- 资助金额:
$ 8.08万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Bronze Age Carian Iasos: Structures, Stratigraphy, and Finds from the area of the Late Roman Agora (ca. 3000-1500 BC)
青铜时代卡里安亚索斯:晚期罗马集市(约公元前 3000-1500 年)地区的结构、地层学和发现物
- 批准号:
AH/I001611/1 - 财政年份:2011
- 资助金额:
$ 8.08万 - 项目类别:
Fellowship