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Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

胰腺癌诊断和治疗策略中心

基本信息

批准号：
10666691
负责人：
Sanku Mallik
金额：
$ 189.41万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10666691
关键词：
American Cancer Society Animals Award Big Data Bioinformatics Biological Models Biomedical Research Biometry Biostatistics Core COVID-19 pandemic Centers of Research Excellence Cessation of life Clinical Collaborations Core Facility Dedications Desmoplastic Diagnosis Diagnostic Disease Drug Delivery Systems Drug Targeting Elements Environment Epigenetic Process Equipment Evaluation Faculty Fluorescence Foundations Funding Funding Opportunities Genetic Genetic Engineering Goals Grant Histocytochemistry Histology Hospitals Human Image Immunohistochemistry Incidence Infrastructure Institution Journals Machine Learning Maintenance Malignant Neoplasms Malignant neoplasm of pancreas Medical center Mentors Mission Modeling Multiomic Data Mus Mutation Nebraska Neoplasm Metastasis North Carolina North Dakota Pancreatic Ductal Adenocarcinoma Paper Patients Peer Review Phase Pilot Projects Postdoctoral Fellow Privatization Publications Publishing R24 Research Research Infrastructure Research Personnel Research Project Grants Science Scientist Secure Services Small Business Innovation Research Grant Social Distance Survival Rate Symptoms Therapeutic Therapeutic Agents Time Tissues Translational Research Travel United States National Institutes of Health Universities University of Texas M D Anderson Cancer Center Work biobank career design doctoral student effective therapy genetic risk factor graduate student imaging modality improved member model development mortality mouse model novel therapeutics pancreatic cancer model pancreatic ductal adenocarcinoma model patient derived xenograft model professor recruit subcutaneous tenure track translational study tumor

项目摘要

PROJECT SUMMARY Although the survival for other cancers improved during the last ten years, the outlook for pancreatic ductal adenocarcinoma (PDAC) remains grim. The average overall 5-year survival rate for PDAC is 10.8%. The mission of the Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer (CDTSPC) in Phase II is to enhance and sustain biomedical research infrastructure at North Dakota State University (NDSU) by developing externally-funded, independent translational research of the Junior Investigators, expanding Core Facility services, and recruiting new investigators. The Covid pandemic-related restrictions hampered our progress in Phase I. Still, the investigators received seven nationally competitive research grants totaling $9.6 million, published more than 50 papers, and graduated 17 Ph. D. students. Two Junior Investigators and three pilot project leaders received tenure and promotion. NDSU hired four new Assistant Professors with research emphasis on pancreatic cancer. Two new Core Facilities were set up – Animal Studies and Biostatistics. The two facilities served 19 COBRE and 33 other investigators. The Animal Core Facility created comprehensive mice models for the first time on campus, including 7 patient-derived mouse models (PDX) of pancreatic cancer. CDTSPC is the only established Facility in North Dakota with the capacity to support foundational and translational research on pancreatic cancer. In Phase II, we will further expand the biomedical infrastructure, emphasizing translational research and prepare for a self-sustaining Center through the following Specific Aims. Aim 1. Provide enhanced mentoring to develop sustainable, independent, translational research projects for Junior Investigators. The three investigators will address three urgent challenges in pancreatic cancer: targeted drug delivery to desmoplastic tumors, synthesis and evaluation of new therapeutic agents, and determining epigenetic-genetic alternations in patient tissues for effective treatment. Each Junior Investigator will have two external mentors to encompass foundational and translational aspects. In addition, a clinician-scientist will serve as the Translational Science Liaison for the Center to bridge the foundational and translational elements. Aim 2. Augment biomedical research infrastructure of NDSU by expanding COBRE Core Facilities. We will expand the Animal Studies Core Facility to include tissue histology, imaging modalities, establish and maintain additional genetically engineered models, continue developing the PDX model systems, and establish a tissue biobank of human, PDX, and mouse pancreatic cancer tissues. In addition, the Biostatistics Core Facility will expand services to support projects using "big data," bioinformatics, and machine-learning analysis. Aim 3. Integrate the Center into the national pancreatic cancer network. We will expand collaboration with eminent pancreatic cancer researchers in the US. We will build human capacity by hiring two new tenure track faculty members and recruiting four new Pilot Project investigators with expertise in translational aspects of pancreatic cancer. The Junior Investigators will compete for grants from NIH, NSF, DoD, and private foundations.

项目概要尽管在过去十年中其他癌症的生存率有所提高，但胰腺导管癌的前景腺癌（PDAC）仍然严峻。 PDAC 的平均总体 5 年生存率为 10.8%。这胰腺癌诊断和治疗策略中心 (CDTSPC) 第二阶段的任务是加强和维持北达科他州立大学 (NDSU) 的生物医学研究基础设施发展初级研究者的外部资助的独立转化研究，扩大核心设施服务，并招募新的调查员。与新冠大流行相关的限制阻碍了我们的第一阶段的进展。尽管如此，研究人员还是获得了七项具有全国竞争力的研究资助，总计 9.6 美元发表论文50余篇，毕业博士生17名。两名初级研究员和三名试点项目领导者获得了终身职位和晋升。 NDSU 聘请了四名新的研究助理教授重点关注胰腺癌。设立了两个新的核心设施——动物研究和生物统计学。这两个设施为 19 名 COBRE 和 33 名其他调查员提供服务。动物核心设施创建了综合校园首次建立小鼠模型，其中包括 7 个胰腺癌患者来源的小鼠模型 (PDX)。 CDTSPC 是北达科他州唯一一家有能力支持基础和胰腺癌的转化研究。第二阶段，我们将进一步扩大生物医学基础设施，强调转化研究并通过以下具体目标为自我维持的中心做好准备。目标 1. 提供强化指导，以开发可持续的、独立的、转化性的研究项目初级调查员。这三位研究人员将解决胰腺癌的三个紧迫挑战：对促纤维增生性肿瘤的药物递送、新治疗剂的合成和评估以及确定患者组织中的表观遗传-遗传改变以实现有效治疗。每个初级研究员将有两个外部导师涵盖基础和转化方面。此外，一名临床医生科学家将提供服务作为该中心的转化科学联络员，在基础要素和转化要素之间架起桥梁。目标 2. 通过扩展 COBRE 核心设施来增强 NDSU 的生物医学研究基础设施。我们将扩大动物研究核心设施，包括组织组织学、成像模式、建立和维护额外的基因工程模型，继续开发 PDX 模型系统，并建立组织人类、PDX 和小鼠胰腺癌组织的生物库。此外，生物统计核心设施将扩大服务范围，以支持使用“大数据”、生物信息学和机器学习分析的项目。目标 3. 将中心纳入国家胰腺癌网络。我们将扩大与以下机构的合作美国著名的胰腺癌研究人员。我们将通过雇用两名新的终身教授来培养人才能力教职人员并招募四名新的试点项目研究人员，他们在转化方面具有专业知识胰腺癌。初级研究人员将争夺来自 NIH、NSF、DoD 和私人基金会的资助。

项目成果

期刊论文数量（49）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Single-Molecule Force Probing of RGD-Binding Integrins on Pancreatic Cancer Cells.

DOI：
10.1021/acsami.1c23361
发表时间：
2022-02-16
期刊：
ACS applied materials & interfaces
影响因子：
9.5
作者：
Alhalhooly L;Confeld MI;Woo SO;Mamnoon B;Jacobson R;Ghosh S;Kim J;Mallik S;Choi Y
通讯作者：
Choi Y

A Miniaturized MicroRNA Sensor Identifies Targets Associated with Weight Loss in a Diet and Exercise Intervention among Healthy Overweight Individuals.

DOI：
10.3390/s22186758
发表时间：
2022-09-07
期刊：
Sensors (Basel, Switzerland)
影响因子：
0
作者：
Jayasooriya V;Johnson N;Bradley A;Kotarsky C;Jepng'etich L;Friesner D;Stastny S;Hackney KJ;Nawarathna D
通讯作者：
Nawarathna D

Development of quantitative immunochromatographic assay for rapid and sensitive detection of carbohydrate antigen 19-9 (CA 19-9) in human plasma.