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Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

胰腺癌诊断和治疗策略中心

基本信息

批准号：
10666691
负责人：
Sanku Mallik
金额：
$ 189.41万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10666691
关键词：
American Cancer Society Animals Award Big Data Bioinformatics Biological Models Biomedical Research Biometry Biostatistics Core COVID-19 pandemic Centers of Research Excellence Cessation of life Clinical Collaborations Core Facility Dedications Desmoplastic Diagnosis Diagnostic Disease Drug Delivery Systems Drug Targeting Elements Environment Epigenetic Process Equipment Evaluation Faculty Fluorescence Foundations Funding Funding Opportunities Genetic Genetic Engineering Goals Grant Histocytochemistry Histology Hospitals Human Image Immunohistochemistry Incidence Infrastructure Institution Journals Machine Learning Maintenance Malignant Neoplasms Malignant neoplasm of pancreas Medical center Mentors Mission Modeling Multiomic Data Mus Mutation Nebraska Neoplasm Metastasis North Carolina North Dakota Pancreatic Ductal Adenocarcinoma Paper Patients Peer Review Phase Pilot Projects Postdoctoral Fellow Privatization Publications Publishing R24 Research Research Infrastructure Research Personnel Research Project Grants Science Scientist Secure Services Small Business Innovation Research Grant Social Distance Survival Rate Symptoms Therapeutic Therapeutic Agents Time Tissues Translational Research Travel United States National Institutes of Health Universities University of Texas M D Anderson Cancer Center Work biobank career design doctoral student effective therapy genetic risk factor graduate student imaging modality improved member model development mortality mouse model novel therapeutics pancreatic cancer model pancreatic ductal adenocarcinoma model patient derived xenograft model professor recruit subcutaneous tenure track translational study tumor

项目摘要

PROJECT SUMMARY Although the survival for other cancers improved during the last ten years, the outlook for pancreatic ductal adenocarcinoma (PDAC) remains grim. The average overall 5-year survival rate for PDAC is 10.8%. The mission of the Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer (CDTSPC) in Phase II is to enhance and sustain biomedical research infrastructure at North Dakota State University (NDSU) by developing externally-funded, independent translational research of the Junior Investigators, expanding Core Facility services, and recruiting new investigators. The Covid pandemic-related restrictions hampered our progress in Phase I. Still, the investigators received seven nationally competitive research grants totaling $9.6 million, published more than 50 papers, and graduated 17 Ph. D. students. Two Junior Investigators and three pilot project leaders received tenure and promotion. NDSU hired four new Assistant Professors with research emphasis on pancreatic cancer. Two new Core Facilities were set up – Animal Studies and Biostatistics. The two facilities served 19 COBRE and 33 other investigators. The Animal Core Facility created comprehensive mice models for the first time on campus, including 7 patient-derived mouse models (PDX) of pancreatic cancer. CDTSPC is the only established Facility in North Dakota with the capacity to support foundational and translational research on pancreatic cancer. In Phase II, we will further expand the biomedical infrastructure, emphasizing translational research and prepare for a self-sustaining Center through the following Specific Aims. Aim 1. Provide enhanced mentoring to develop sustainable, independent, translational research projects for Junior Investigators. The three investigators will address three urgent challenges in pancreatic cancer: targeted drug delivery to desmoplastic tumors, synthesis and evaluation of new therapeutic agents, and determining epigenetic-genetic alternations in patient tissues for effective treatment. Each Junior Investigator will have two external mentors to encompass foundational and translational aspects. In addition, a clinician-scientist will serve as the Translational Science Liaison for the Center to bridge the foundational and translational elements. Aim 2. Augment biomedical research infrastructure of NDSU by expanding COBRE Core Facilities. We will expand the Animal Studies Core Facility to include tissue histology, imaging modalities, establish and maintain additional genetically engineered models, continue developing the PDX model systems, and establish a tissue biobank of human, PDX, and mouse pancreatic cancer tissues. In addition, the Biostatistics Core Facility will expand services to support projects using "big data," bioinformatics, and machine-learning analysis. Aim 3. Integrate the Center into the national pancreatic cancer network. We will expand collaboration with eminent pancreatic cancer researchers in the US. We will build human capacity by hiring two new tenure track faculty members and recruiting four new Pilot Project investigators with expertise in translational aspects of pancreatic cancer. The Junior Investigators will compete for grants from NIH, NSF, DoD, and private foundations.

项目总结尽管其他癌症的存活率在过去十年中有所改善，但胰腺导管的前景腺癌(PDAC)仍然很严重。PDAC的平均5年生存率为10.8%。这个胰腺癌诊断和治疗策略中心(CDTSPC)在第二阶段的任务是通过以下方式加强和维持北达科他州立大学(NDSU)的生物医学研究基础设施发展外部资助的、独立的初级调查人员翻译研究，扩大核心设施服务，并招募新的调查人员。Covid大流行相关的限制阻碍了我们的尽管如此，第一阶段的进展仍然是，研究人员获得了七项全国竞争研究拨款，总额为9.6美元发表论文50余篇，毕业博士生17人。两名初级调查员和三名初级调查员试点项目负责人获得任期和晋升。南洋理工大学聘请了四名新的助理教授进行研究重点是胰腺癌。设立了两个新的核心设施--动物研究和生物统计学。这个两个设施为19名科布雷和33名其他调查人员提供服务。动物核心设施创建了全面的首次在校园建立小鼠模型，包括7个胰腺癌患者来源的小鼠模型(PDX)。 CDTSPC是北达科他州唯一成立的机构，有能力支持基础和胰腺癌的转化性研究。在第二阶段，我们将进一步扩大生物医学基础设施，强调翻译研究，并通过以下具体目标为自给自足的中心做好准备。目标1.提供加强的指导，以开发可持续的、独立的、可转换的研究项目初级调查员。这三名研究人员将解决胰腺癌的三个紧迫挑战：有针对性促结缔组织增生性肿瘤的药物传递，新治疗药物的合成和评价，以及确定表观遗传--患者组织中有效治疗的遗传改变。每名初级调查员将有两名外部导师涵盖基础和翻译方面。此外，一名临床医生兼科学家将为作为该中心的翻译科学联络人，为基础和翻译要素架起桥梁。目的2.通过扩建科布雷核心设施，增强南大生物医学研究基础设施。我们会扩大动物研究核心设施，包括组织组织学、成像方式、建立和维护其他基因工程模型，继续开发PDX模型系统，并建立组织人、PDX和小鼠胰腺癌组织的生物库。此外，生物统计核心基金将扩大服务范围，支持使用“大数据”、生物信息学和机器学习分析的项目。目的3.将该中心纳入国家胰腺癌网络。我们将通过以下方式扩大合作美国著名的胰腺癌研究人员。我们将通过雇佣两个新的终身教职轨道来建设人力资源能力教职员工和招聘四名新的试点项目调查员，他们在翻译方面具有专业知识胰腺癌。初级调查人员将竞争来自NIH、NSF、国防部和私人基金会的拨款。

项目成果

期刊论文数量（49）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Single-Molecule Force Probing of RGD-Binding Integrins on Pancreatic Cancer Cells.

DOI：
10.1021/acsami.1c23361
发表时间：
2022-02-16
期刊：
ACS applied materials & interfaces
影响因子：
9.5
作者：
Alhalhooly L;Confeld MI;Woo SO;Mamnoon B;Jacobson R;Ghosh S;Kim J;Mallik S;Choi Y
通讯作者：
Choi Y

A Miniaturized MicroRNA Sensor Identifies Targets Associated with Weight Loss in a Diet and Exercise Intervention among Healthy Overweight Individuals.

DOI：
10.3390/s22186758
发表时间：
2022-09-07
期刊：
Sensors (Basel, Switzerland)
影响因子：
0
作者：
Jayasooriya V;Johnson N;Bradley A;Kotarsky C;Jepng'etich L;Friesner D;Stastny S;Hackney KJ;Nawarathna D
通讯作者：
Nawarathna D

Development of quantitative immunochromatographic assay for rapid and sensitive detection of carbohydrate antigen 19-9 (CA 19-9) in human plasma.