Administrative Core: Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

行政核心：胰腺癌诊断和治疗策略中心

• 批准号: 8813059
• 负责人: Sanku Mallik
• 金额: $ 86.74万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813059
• 关键词: Address; Advisory Committees; Ally; Animal Model; Animals; Award; Biomedical Research; Cancer Center; Cell model; Core Facility; Core Grant; Detection; Development Plans; Diagnostic; Discipline of Nursing; Disease; Educational workshop; Ensure; Equilibrium; Equipment; Evaluation; Faculty; Family; Funding; Funding Agency; Goals; Grant; Growth; Institution; Journals; Lead; Leadership; Malignant neoplasm of pancreas; Manuscripts; Mentors; Mission; Monoclonal Antibody R24; North Dakota; Personnel Management; Persons; Pharmacy facility; Pilot Projects; Positioning Attribute; Process; Professional Competence; Publications; Published Comment; Recombinant Proteins; Recommendation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Scheme; Science; Secure; Strategic Planning; Therapeutic; Time; Training; Translational Research; Travel; United States National Institutes of Health; Universities; Videoconferences; Videoconferencing; Writing; anticancer research; base; career development; college; design; expression cloning; fundamental research; infrastructure development; mathematical sciences; meetings; programs; ranpirnase; research study; success; tenure track; translational study; undergraduate student

__________________________________________________________________________________________ Project Summary (Administrative Core) We are proposing to establish a "Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer" (CDTSPC) in North Dakota State University (NDSU). The Center will conduct fundamental and translational studies devoted to the detection and control of pancreatic cancer at cellular and animal model levels. The goals of this Center are to develop self-sustaining research programs by junior investigators, to increase the number of NIH-funded research grants, to enhance the infrastructure of NDSU to promote biomedical research, and to expand the University's capability to establish the disease specific program particularly on pancreatic cancer. The Administrative Core of the Center will facilitate and ensure that all the components of the Center are functioning efficiently and successfully. The long-term objective of this proposal is to create a flourishing, self- sustaining and internationally-visible center at NDSU for advanced research (fundamental as well as translational) on pancreatic cancer. The proposed center is designed to strengthen the academic roadmaps and strategic plans for the College of Pharmacy, Nursing, and Allied Sciences and the College of Science and Mathematics. These goals will be accomplished through the following Specific Aims. (1) Efficiently and Successfully Direct the Administrative Core. The Administrative Core will provide research support to the junior investigators, and ensure that they have access to the Core Facilities and equipment needed to make rapid progress. The junior investigators will be mentored for cloning, expression and purification of recombinant proteins needed for the proposed projects by the Co-Director, Dr. D. K. Srivastava. The junior investigators will also be provided with training workshops on responsible conduct of research, grant writing, manuscript writing, efficient financial/ personnel management, leadership skills, and career-family balance. We anticipate that these endeavors will cumulatively lead to publications in high impact journals and facilitate the transition of the supported junior investigators to externally funded independent investigators. The Center will conduct formative and summative evaluations of the Administrative Core, junior investigators, the proposed Animal Core Facility, and the mentoring/career development plans. Any weakness noted in these evaluations and other recommendations will be promptly implemented to ensure progress and success of the Center in gaining a self-sustaining status. (2) Develop and implement a result-oriented, tailored Mentoring/Career Development Plan for accelerating the transition of the junior investigators to independently funded investigators. Each junior investigator will have an internal, an external mentor and a tailored mentoring plan for successful graduation to the independent investigator status. The Mentors will provide guidance to junior investigators regarding navigating research problems, future research directions, organization and presentation of manuscripts for high-impact journals, and provide effective strategies for writing successful proposals. The Mentoring/Career Development Plan will be assessed by formative and summative evaluation strategies. (3) Increase the number of biomedical researchers on NDSU campus. This goal will be accomplished by recruiting 4 Pilot Project investigators, 4 Postdoctoral Associates, 2 technicians, 6 graduate and 4 undergraduate students. In addition, NDSU Provost has committed two new tenure-track faculty positions for the proposed Center. We will recruit the faculty during the first and third years to ensure continued growth of the proposed center. As the junior investigators graduate to the independent investigator status, the PIs for the Pilot Project will gain junior investigator status. We will then include new Pilot Projects through a competitive process. (4) Attain a self-sustaining status for the proposed Center. The Director, Co-Director and junior investigators will compete for Institutional Training Grants (T32), Core Grants (P30), Infrastructure Development Grant (R24), and most importantly, Research Project Grants (R01) from NIH and other grants from other funding agencies (federal and non-federal). In order to expand research opportunities, the center will actively collaborate with regional and national institutions focused on pancreatic cancer research. __________________________________________________________________________________________

__________________________________________________________________________________________ 项目摘要(管理核心) 我们建议建立一个“胰腺癌诊断和治疗策略中心”。 北达科他州立大学(NDSU)的CDTSPC。该中心将进行基础和翻译 致力于在细胞和动物模型水平上检测和控制胰腺癌的研究。目标 该中心的主要任务是由初级调查人员制定自给自足的研究计划，以增加 NIH资助的研究补助金，以加强NDSU的基础设施，以促进生物医学研究，并 扩大该大学建立疾病特别是胰腺癌专项计划的能力。 中心的行政核心将促进并确保中心的所有组成部分 高效而成功地发挥作用。这项提议的长期目标是创造一个繁荣、自我 NDSU高级研究中心的持续性和国际知名度(基础和 译文)关于胰腺癌。拟建的中心旨在加强学术路线图和 药学、护理及相关科学学院和理工学院的战略计划 数学。这些目标将通过以下具体目标来实现。 (1)高效、成功地指导行政核心。行政核心将提供研究 支持初级调查人员，并确保他们能够使用所需的核心设施和设备 取得长足进步。初级调查人员将接受指导，进行克隆、表达和纯化 联合主任D·K·斯里瓦斯塔瓦博士提议的项目所需的重组蛋白。三年级的 还将为调查人员提供关于负责任地进行研究、编写赠款、 手稿写作、高效的财务/人事管理、领导技能和事业与家庭的平衡。我们 预计这些努力将累积导致在影响较大的期刊上发表文章，并促进 将得到支助的初级调查员过渡到外部资助的独立调查员。该中心将 对行政核心、初级调查员、拟议的 动物核心设施，以及指导/职业发展计划。在这些评估中发现的任何弱点 和其他建议将迅速得到落实，以确保中心在#年取得进展和成功 获得自给自足的地位。 (2)制定和实施以结果为导向、量身定做的指导/职业发展计划，以加快 初级调查员过渡到独立资助的调查员。每名初级调查员将有一名 内部、外部导师和为独立人士成功毕业而量身定做的指导计划 调查员身份。导师将为初级调查人员提供导航研究方面的指导 问题、未来研究方向、高影响力期刊稿件的组织和呈现 为撰写成功的建议书提供有效的策略。指导/职业发展计划将是 通过形成性和终结性评价策略进行评估。 (3)增加南大校区生物医学研究人员数量。这一目标将通过以下方式实现 招聘4名试点项目调查员、4名博士后助理、2名技术员、6名研究生和4名本科生 学生们。此外，南洋理工大学教务长已承诺为拟议的 中心。我们将在第一年和第三年招聘教员，以确保拟议的 中间。随着初级调查员升级到独立调查员的地位，试点项目的个人资料 将获得初级调查员的身份。然后，我们将通过竞争过程纳入新的试点项目。 (4)使拟建中心达到自给自足的状态。主任、联席主任和初级调查员将 竞争机构培训补助金(T32)、核心补助金(P30)、基础设施发展补助金(R24)和 最重要的是，来自NIH的研究项目补助金(R01)和来自其他资助机构的其他赠款(联邦 和非联邦)。为了扩大研究机会，中心将积极与地区和地区合作 国家机构专注于胰腺癌的研究。 __________________________________________________________________________________________