The Child Heath Research Center

儿童健康研究中心

• 批准号: 8969683
• 负责人: GARY ROBERT FLEISHER
• 金额: $ 37.41万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8969683
• 关键词: Antigens; Area; Basic Science; Biochemistry; Boston; Child; Child health care; Childhood; Country; Development; Disease; Endocrinology; Ensure; Epilepsy; Faculty; Focal Segmental Glomerulosclerosis; Funding; Goals; Grant; Heart Abnormalities; Hematology; Hospitals; Infectious Disease Immunology; Investigation; Laboratories; Lead; Malaria; Medicine; Mentors; Mentorship; Modality; Molecular; Nephrology; Neurology; Pediatric Hospitals; Physicians; Positioning Attribute; Pulmonology; Research; SECTM1 gene; Scholarship; Scientist; Secure; Self-Examination; Site Visit; T-Cell Development; Translational Research; United States National Institutes of Health; Viral; Wages; Work; base; career; cost; gene discovery; improved; instructor; medical schools; member; novel therapeutics; nuclear reprogramming; oncology; pediatrician; professor; programs; structural biology

DESCRIPTION (provided by applicant): The goal of the Children's Hospital Boston CHRCDA Program is to develop pediatrician physician-scientists who are performing world-class research that will improve health care for children in this country and around the world. Our Scholars will be performing laboratory-based basic and translational research under the mentorship of outstanding scientists at Children's Hospital and other Harvard Associated Hospitals and Harvard Medical School. Our program has been established to ensure the development of independent scientists. In this proposal we describe a program that included intensive mentoring, a comprehensive didactic program, and a program to ensure the scientific development of Scholars. Programmatic oversight will be provided by an External Site Visit Committee and an Internal Steering Committee. Plans are in place for programmatic self-evaluation and for review of Scholar Progress. We propose to continue the funding of four Scholar positions. Most Scholars will be funded for two years, unless they secure independent K-level or other funding during their first year of Scholarship. Historically, the Department of Medicine has funded the majority of the salary component of each Scholar, such that most of the K12 funding is used to cover the cost of supplies and research technicians. The Department has also in most years funded a position to support a fifth Scholar position. Scholars will be faculty members most often at the rank of Instructor, but Assistant Professors who are early in the development of their independent careers will also be eligible to apply. Scholars will be considered at any point from the beginning of their Instructorship to the point where they are considered to be two years away from submitting their first R-level NIH grant or equivalent. Scholars will work in a broad range of scientific investigations. Past and present Scholars are working in areas such as the mechanism of nuclear reprogramming, structural biology of malaria antigens, biochemistry of viral entry, gene discovery in short stature, cardiac malformations, focal segmental glomerulosclerosis and familial epilepsy, T cell development and many other areas. These investigations will elucidate fundamental molecular mechanisms and will lead to the development of new therapeutic modalities in all areas of pediatric disease, including hematology/oncology, endocrinology, nephrology, infectious disease, immunology, pulmonology and neurology.

描述（由申请人提供）：儿童医院波士顿CHRCDA计划的目标是培养儿科医生，医生，科学家谁正在进行世界一流的研究，将改善卫生保健的儿童在这个国家和世界各地。我们的学者将在儿童医院和其他哈佛附属医院和哈佛医学院的杰出科学家的指导下进行基于实验室的基础和转化研究。我们的计划旨在确保独立科学家的发展。在这份提案中，我们描述了一个计划，包括密集的指导，一个全面的教学计划，并计划，以确保学者的科学发展。方案监督将由外部研究中心访问委员会和内部指导委员会提供。项目自我评估和学者进步审查计划已经到位。我们建议继续资助四个学者职位。大多数学者将获得两年的资助，除非他们在奖学金的第一年获得独立的K级或其他资助。从历史上看，医学部资助了每个学者的大部分工资组成部分，这样K12资金的大部分用于支付用品和研究技术人员的费用。该部还在大多数年份资助了一个职位，以支持第五个学者职位。学者将是教员最经常在讲师的职级，但助理教授谁是在他们的独立职业发展的早期也将有资格申请。学者将被认为在任何点从他们的指导开始的点，他们被认为是两年远离提交他们的第一个R级NIH补助金或同等。学者们将从事广泛的科学研究。过去和现在的学者在诸如核重编程的机制，疟疾抗原的结构生物学，病毒进入的生物化学，身材矮小的基因发现，心脏畸形，局灶节段性肾小球硬化和家族性癫痫，T细胞发育等许多领域工作。这些研究将阐明基本的分子机制，并将导致儿科疾病的所有领域，包括血液学/肿瘤学，内分泌学，肾脏学，感染性疾病，免疫学，肺病学和神经学的新的治疗方式的发展。