The Child Heath Research Center

儿童健康研究中心

• 批准号: 8403048
• 负责人: GARY ROBERT FLEISHER
• 金额: $ 27.33万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2016-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8403048
• 关键词: Antigens; Area; Basic Science; Biochemistry; Boston; Child; Child health care; Childhood; Congenital Heart Defects; Country; Development; Disease; Endocrinology; Ensure; Epilepsy; Evaluation; Faculty; Focal Segmental Glomerulosclerosis; Funding; Goals; Grant; Hematology; Hospitals; Infectious Disease Immunology; Investigation; Laboratories; Lead; Malaria; Medicine; Mentors; Mentorship; Modality; Molecular; Nephrology; Neurology; Pediatric Hospitals; Physicians; Positioning Attribute; Pulmonology; Research; SECTM1 gene; Scholarship; Scientist; Secure; Site Visit; T-Cell Development; Translational Research; United States National Institutes of Health; Viral; Wages; Work; base; career; cost; gene discovery; improved; instructor; medical schools; member; novel therapeutics; nuclear reprogramming; oncology; pediatrician; professor; programs; structural biology

DESCRIPTION (provided by applicant): The goal of the Children's Hospital Boston CHRCDA Program is to develop pediatrician physician-scientists who are performing world-class research that will improve health care for children in this country and around the world. Our Scholars will be performing laboratory-based basic and translational research under the mentorship of outstanding scientists at Children's Hospital and other Harvard Associated Hospitals and Harvard Medical School. Our program has been established to ensure the development of independent scientists. In this proposal we describe a program that included intensive mentoring, a comprehensive didactic program, and a program to ensure the scientific development of Scholars. Programmatic oversight will be provided by an External Site Visit Committee and an Internal Steering Committee. Plans are in place for programmatic self-evaluation and for review of Scholar Progress. We propose to continue the funding of four Scholar positions. Most Scholars will be funded for two years, unless they secure independent K-level or other funding during their first year of Scholarship. Historically, the Department of Medicine has funded the majority of the salary component of each Scholar, such that most of the K12 funding is used to cover the cost of supplies and research technicians. The Department has also in most years funded a position to support a fifth Scholar position. Scholars will be faculty members most often at the rank of Instructor, but Assistant Professors who are early in the development of their independent careers will also be eligible to apply. Scholars will be considered at any point from the beginning of their Instructorship to the point where they are considered to be two years away from submitting their first R-level NIH grant or equivalent. Scholars will work in a broad range of scientific investigations. Past and present Scholars are working in areas such as the mechanism of nuclear reprogramming, structural biology of malaria antigens, biochemistry of viral entry, gene discovery in short stature, cardiac malformations, focal segmental glomerulosclerosis and familial epilepsy, T cell development and many other areas. These investigations will elucidate fundamental molecular mechanisms and will lead to the development of new therapeutic modalities in all areas of pediatric disease, including hematology/oncology, endocrinology, nephrology, infectious disease, immunology, pulmonology and neurology.

描述（由申请人提供）：波士顿儿童医院CHRCDA项目的目标是培养从事世界级研究的儿科医生、内科医生和科学家，这些研究将改善美国和世界各地儿童的医疗保健。我们的学者将在儿童医院和其他哈佛联合医院和哈佛医学院的杰出科学家的指导下进行实验室基础和转化研究。我们的计划是为了保证独立科学家的发展而制定的。在这个建议中，我们描述了一个包括强化指导、综合教学计划和确保学者科学发展的计划。方案监督将由外部实地考察委员会和内部指导委员会提供。制定计划进行程序性自我评估，并审查学生进展情况。我们建议继续资助四个学者职位。大多数学者将获得两年的资助，除非他们在奖学金的第一年获得独立的k级或其他资助。从历史上看，医学系资助了每位学者的大部分工资部分，因此K12的大部分资金用于支付用品和研究技术人员的费用。在大多数年份，该部门还资助了一个职位，以支持第五个学者职位。学者通常是教员级别的教员，但处于独立职业发展初期的助理教授也有资格申请。学者将被考虑在任何时候，从他们的指导开始，到他们被认为是两年远离提交他们的第一个r级NIH资助或同等。学者们将从事广泛的科学研究。过去和现在的学者在核重编程机制、疟疾抗原结构生物学、病毒进入生物化学、矮个子基因发现、心脏畸形、局灶节段性肾小球硬化和家族性癫痫、T细胞发育和许多其他领域工作。这些研究将阐明基本的分子机制，并将导致儿科疾病所有领域的新治疗模式的发展，包括血液学/肿瘤学、内分泌学、肾脏病学、传染病、免疫学、肺脏学和神经学。