RESEARCH TRAINING IN PEDIATRIC EMERGENCY MEDICINE

描述（由申请人提供）：儿童医院（CH）现有的儿科急诊医学奖学金项目致力于为急诊医学研究的学术研究者做好准备。本建议中概述的培训将以该研究金过去培养富有成效和忠诚的研究人员的杰出经验为基础。建议的研究培训计划的基本特征包括直接参与研究，结合全面的教学指导课程和丰富活动，为临床研究和生物医学科学的现代技术提供深厚的基础。A)研究轨迹、学科和主题（图1，第72页）。受训者将接受以下三个方向之一的培训：1)临床调查，2)医学信息学或3)基础科学。临床调查的学员将掌握生物统计学、临床流行病学、健康结果研究/质量控制和临床实验室研究（转化研究）等学科的技能。那些追求医学信息学的学生将学习数据挖掘、数据建模、控制医学词汇的使用、基于web的应用程序编程和设计自动化决策支持系统等学科。基础科学学员的学科包括分子生物学、细胞免疫学、生理学和药理学。通过掌握这些学科获得的工具将应用于儿科急诊医学的特定主题的研究，培训教师的成员已经建立了专业知识：临床有效性/医疗决策、传染病、免疫学、肺病学（哮喘）、血液学（镰状细胞性贫血）、创伤学、药理学和医学毒理学/环境卫生。B)培训水平、背景和学员人数。本申请书建议培养博士后。招收博士后8名；两名博士后研究员将每年开始培训，并在研究培训中保持至少两到三年（取决于轨道），由该奖项提供支持。C)培训设施。研究培训将在一组在CH、哈佛医学院（HMS）、布莱根钱宁实验室和妇女医院、哈佛公共卫生学院和麻省理工学院广泛互动的知名调查人员的指导下进行。实验室位于哈佛大学的恩德斯研究大楼、哈佛医学院和钱宁实验室。教学教育项目将包括儿科急诊医学部、HMS、哈佛公共卫生学院、麻省理工学院和哈佛大学提供的课程。

DESCRIPTION (provided by applicant): The existing fellowship program in Pediatric Emergency Medicine at Children's Hospital (CH) has been dedicated to the preparation of academic investigators for a career in emergency medicine research. The training outlined in this proposal will build on the outstanding past experience of the fellowship in graduating productive and committed investigators. Fundamental features of the proposed Research Training Program include direct research participation in conjunction with a comprehensive curriculum of didactic instruction and enrichment activities to provide a deep foundation in modern techniques for clinical investigation and biomedical science. A) Research Tracks, Disciplines, and Themes (Figure 1, page 72). Trainees will undertake training in one of three tracks: 1) clinical investigation, 2) medical informatics or 3) basic science. The trainees in clinical investigation will acquire skills in the disciplines of biostatistics, clinical epidemiology, health outcomes research/quality control and clinical laboratory research (translational research). Those pursuing medical informatics will study the disciplines of data mining, data modeling, use of controlled medical vocabularies, programming web-based applications, and designing automated decision support systems. Disciplines for basic science trainees will include molecular biology, cellular immunology, physiology and pharmacology. The tools acquired through mastery of these disciplines will be applied to studies addressing specific themes in Pediatric Emergency Medicine for which members of the training faculty have established expertise: Clinical Effectiveness/Medical Decision Making, Infectious Diseases, Immunology, Pulmonology (Asthma), Hematology (Sickle cell anemia), Trauma, Pharmacology, and Medical Toxicology/Environmental Health. B) Level of Training, Background and Numbers of Trainees. This application proposes post- doctoral training. Eight post-doctoral positions are requested; two post- doctoral fellows will begin training each year and remain in research training for a minimum of two or three years (depending on track), supported by this award. C) Training Facilities. Research training will take place under the mentorship of a group of established investigators with extensive existing interactions at CH, Harvard Medical School (HMS), The Channing Laboratory of Brigham and Women's Hospital, Harvard School of Public Health and MIT. Laboratories are present at the Enders Research Building at CH, The Harvard Medical School and The Channing Laboratory. Didactic educational programs will include those offered within the Division of Pediatric Emergency Medicine, and through HMS, Harvard School of Public Health, MIT and Harvard University.