The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers

干细胞和微环境在胃肠道癌症中的作用

• 批准号: 9186833
• 负责人: Timothy Cragin Wang
• 金额: $ 94.2万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-07 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9186833
• 关键词: 3-Dimensional; Area; Cancer Control; Cell model; Chronic; Collaborations; Collection; Colon; Colon Carcinoma; Development; Elements; Endothelial Cells; Epithelial; Esophageal; Evolution; Fibroblasts; Genetically Engineered Mouse; Helicobacter; Helicobacter Infections; Immunity; In Vitro; Inflammation; Investigation; Laboratories; Lymphoid Cell; Malignant Neoplasms; Malignant neoplasm of esophagus; Malignant neoplasm of gastrointestinal tract; Malignant neoplasm of pancreas; Modeling; Mutate; Myeloid Cells; Myeloproliferative disease; Natural regeneration; Nerve; Organoids; Pancreas; Pathogenesis; Pre-Clinical Model; Regulation; Role; Stem cells; Stomach; Stomach Neoplasms; Stromal Cells; Testing; Tumor Immunity; Work; cancer cell; cell behavior; cholinergic; improved; malignant stomach neoplasm; mouse model; neuroregulation; progenitor; programs; stem cell niche; tumor; tumor microenvironment; tumor progression

Summary/Abstract This project seeks to investigate the role of nerves and other stromal cells in the development of digestive cancers, including stomach, esophageal, colon and pancreas. The project builds on previous work that suggests that these elements can regulate stem cells, and that inhibiting stromal cells in the microenvironment, it may be possible to inhibit the development of tumors.

摘要/摘要 该项目旨在研究神经和其他基质细胞在发育中的作用， 消化系统癌症，包括胃癌、食道癌、结肠癌和胰腺癌。该项目建立在 以前的工作表明，这些元素可以调节干细胞，抑制 在微环境中的基质细胞，有可能抑制肿瘤的发展。