The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
批准号:
10532704
负责人:
Timothy Cragin Wang
金额:
$89.38万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-12-07 至 2023-08-31
关键词:
3-DimensionalAreaCancer ControlCell modelChronicCollaborationsCollectionColonColon CarcinomaCre driverDevelopmentElementsEndothelial CellsEpitheliumEsophagusEvolutionFibroblastsGenetically Engineered MouseHelicobacterHelicobacter InfectionsImmunityIn VitroInflammationInvestigationLaboratoriesLymphoid CellMalignant NeoplasmsMalignant neoplasm of esophagusMalignant neoplasm of gastrointestinal tractMalignant neoplasm of pancreasModelingMutateMyeloid CellsMyeloproliferative diseaseNatural regenerationNerveOrganoidsPancreasPathogenesisPre-Clinical ModelProductivityRegulationRoleStomachStomach NeoplasmsStromal CellsTestingTumor ImmunityWorkcancer cellcell behaviorcholinergicimprovedinducible Cremalignant stomach neoplasmneuroregulationprogenitorprogramsstem cell nichestem cellstumortumor microenvironmenttumor progression
中文摘要
摘要/摘要
该项目旨在研究神经和其他基质细胞在发育中的作用,
消化系统癌症,包括胃癌、食道癌、结肠癌和胰腺癌。该项目建立在
以前的工作表明,这些元素可以调节干细胞,抑制
在微环境中的基质细胞,有可能抑制肿瘤的发展。
英文摘要
Summary/Abstract
This project seeks to investigate the role of nerves and other stromal cells in the development of
digestive cancers, including stomach, esophageal, colon and pancreas. The project builds on
previous work that suggests that these elements can regulate stem cells, and that inhibiting
stromal cells in the microenvironment, it may be possible to inhibit the development of tumors.
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会议论文
Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor Cells
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批准号:10490463
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资助金额:$49.9万
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财政年份:2021
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负责人:Timothy Cragin Wang
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依托单位:
Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor Cells
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批准号:10686228
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项目类别:
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资助金额:$49.9万
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财政年份:2021
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负责人:Timothy Cragin Wang
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依托单位:
Gastrin Regulation of Gastric Antral Stem and Corpus Progenitor Cells
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批准号:10367556
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项目类别:
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资助金额:$49.9万
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财政年份:2021
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负责人:Timothy Cragin Wang
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The role of stem cells and the microenvironment in gastrointestinal cancers
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批准号:10737925
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资助金额:$98.7万
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财政年份:2016
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依托单位:
The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
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批准号:9186833
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资助金额:$94.2万
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负责人:Timothy Cragin Wang
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The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
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批准号:10307622
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项目类别:
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资助金额:$89.38万
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财政年份:2016
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负责人:Timothy Cragin Wang
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The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers
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批准号:10059178
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项目类别:
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财政年份:2016
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负责人:Timothy Cragin Wang
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依托单位:
Quiescent Dclk1+ stem cells in the mouse intestine
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批准号:8865612
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项目类别:
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资助金额:$31.17万
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财政年份:2013
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负责人:Timothy Cragin Wang
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依托单位:
Quiescent Dclk1+ stem cells in the mouse intestine
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批准号:8577370
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项目类别:
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资助金额:$32.0万
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财政年份:2013
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负责人:Timothy Cragin Wang
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依托单位:
Quiescent Dclk1+ stem cells in the mouse intestine
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批准号:8547458
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项目类别:
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资助金额:$34.78万
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财政年份:2012
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负责人:Timothy Cragin Wang
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依托单位:
Project 1: Role of Microbiota and Myeloid cells in Mouse Models of Barretts Esophagus
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批准号:10183178
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项目类别:
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Administrative and Bioinformatics Core
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批准号:8555379
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项目类别:
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资助金额:$11.68万
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财政年份:2011
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依托单位:
Myofibroblasts in Gastrointestinal Cancers
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批准号:8212777
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项目类别:
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资助金额:$50.5万
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财政年份:2011
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负责人:Timothy Cragin Wang
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依托单位:
Myofibroblasts in Gastrointestinal Cancers
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批准号:8705460
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项目类别:
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资助金额:$50.68万
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财政年份:2011
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负责人:Timothy Cragin Wang
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依托单位:
Administrative and Bioinformatics Core
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批准号:8256912
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项目类别:
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资助金额:$11.36万
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财政年份:2011
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负责人:Timothy Cragin Wang
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依托单位:
Administrative Core
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批准号:10270338
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项目类别:
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资助金额:$16.2万
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财政年份:2011
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依托单位:
Myofibroblasts in Gastrointestinal Cancers
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批准号:8701442
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项目类别:
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资助金额:$13.55万
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财政年份:2011
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负责人:Timothy Cragin Wang
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依托单位:
Myofibroblasts in Gastrointestinal Cancers
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批准号:8337299
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项目类别:
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资助金额:$50.42万
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财政年份:2011
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负责人:Timothy Cragin Wang
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依托单位:
Myofibroblasts in Gastrointestinal Cancers
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批准号:8539354
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项目类别:
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资助金额:$47.07万
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财政年份:2011
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负责人:Timothy Cragin Wang
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依托单位:
Multidisciplinary Training in Translational Gastrointestinal and Liver Research
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批准号:8517691
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项目类别:
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