RDoC Domains Underlying Emotional Health and Trajectories of Psychopathology in Families of WTC First Responders and Evacuees: A Genome-Wide GxE Study

世贸中心急救人员和撤离人员家庭情绪健康和精神病理学轨迹背后的 RDoC 领域：一项全基因组 GxE 研究

• 批准号: 9340140
• 负责人: Lupo Geronazzo-Alman
• 金额: $ 59.64万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9340140
• 关键词: RDoC; Domains; Underlying; Emotional; Health

The role of familial/parental factors in modulating youths’ reactions to terrorism is supported by the scientific literature, including the Child Psychiatric Epidemiology Group’s (CPEG) findings from youth assessed six months after 9/11 (N=8,236; see Significance). Those findings led to a NICHD-funded grant (Wave 1-2 WTC Family Study) to understand the impact, over time, of parental direct WTC-exposure on their children’s psychopathology. For that study, N=855 families (parents + one child) of WTC First Responders, WTC Evacuees and local Residents were recruited from the World Trade Center Health Registry (WTCHR), as well as 9/11 unexposed Control families. The Wave 1-2 WTC Family Study was innovative and unique in that it: (a) examined the effects of direct exposure of parents to the consequential effect of indirect (“take home”) exposure on their children, (b) it followed families over time, and (c) assessed a broad array of psychiatric disorders in parents and children with DSM diagnostic instruments. Since initiation of the WTCHR and the Wave 1-2 WTC Family Study, NIMH developed the Research Domain Criteria (RDoC) project, a new way to classify mental disorders based on validated behavioral functions, supported by neural circuits. RDoC domains have quickly illuminated the conceptualization of psychopathology by providing a more comprehensive framework of functions/deficits across a spectrum of disorders and the health-illness dimension. This conceptualization is critical to understanding the long-term consequences to individuals and families with 9/11 exposure. Additionally, the explosion of high-throughput technologies has led to a more comprehensive view of the genetic architecture of observable behaviors and of gene-environment interactions (G×E), which may be critical in the development of individualized treatment plans for 9/11 exposed individuals. To date, there has been no other 9/11 investigation that encompasses families, even of First Responder, WTC and Residential Evacuee families, the most adversely impacted WTC population. Based on findings from the Wave 1-2 WTC Family Study on the effects of parental WTC-exposure/psychiatric disorders on their child’s’ psychopathology, as well as other epidemiological, behavioral and genetic findings by CPEG regarding these individuals (see Approach-C.4), we propose to follow-up the same families for a 3rd wave, to examine how four key RDoC domains of functioning (negative valence; positive valence; cognitive systems; social cognition) are associated upward with (i) long-term psychiatric outcomes (DSM disorders), (ii) emotional health (psychological resilience), and (iii) trajectories of psychopathology, and downward, with interactions between genetic variation and direct/indirect WTC exposures.

家庭/父母因素在调节青少年对恐怖主义的反应方面所起的作用得到了以下方面的支持： 科学文献，包括儿童精神病学流行病学小组（CPEG）对青少年评估的结果 9/11后6个月（N= 8，236;见显著性）。这些发现导致了NICHD资助的赠款（第1-2波 WTC家庭研究），以了解随着时间的推移，父母直接接触WTC对其子女的影响。 精神病理学对于该研究，N=855个WTC第一反应者家庭（父母+一个孩子），WTC 疏散人员和当地居民也是从世界贸易中心健康登记处（WTCHR）招募的。 9/11未暴露的对照组家庭WTC第1-2波家庭研究具有创新性和独特性，因为它： 研究了父母直接接触间接（“带回家”）的后果的影响 （B）它随时间推移跟踪家庭，（c）评估了一系列广泛的精神疾病。 父母和孩子的DSM诊断仪器。 自从WTTERA和Wave 1-2 WTC家庭研究开始以来，NIMH开发了研究 领域标准（RDoC）项目，一种基于验证行为的精神障碍分类的新方法 功能，由神经回路支持。RDoC领域已经迅速阐明了 通过提供一个更全面的功能/缺陷的框架， 疾病和健康-疾病维度。这种概念化对于理解长期 对9/11暴露的个人和家庭的影响。此外，高吞吐量的爆炸式增长 技术的发展使人们对可观察行为的遗传结构和 基因-环境相互作用（G×E），这可能是发展个体化治疗的关键 9/11暴露者的计划 到目前为止，还没有其他9/11调查涉及家庭，甚至是第一家庭。 响应者，世贸中心和住宅疏散家庭，最不利的影响世贸中心人口。基于 关于父母WTC暴露/精神疾病影响的第1-2波WTC家庭研究的结果 关于他们孩子的精神病理学，以及CPEG的其他流行病学，行为和遗传学发现 关于这些人（见方法C.4），我们建议对同一家庭进行第三波随访， 检查四个关键的RDoC功能域（负效价;正效价;认知系统; 社会认知）与（i）长期精神病结果（DSM障碍），（ii） 情绪健康（心理弹性），（iii）精神病理学的轨迹，以及向下， 遗传变异和直接/间接WTC暴露之间的相互作用。