Air Quality, Child, and Adult Health in Homes Where E-Cigarettes Are Smoked

吸电子烟的家庭中的空气质量、儿童和成人健康

• 批准号: 9412238
• 负责人: Terry Gordon
• 金额: $ 50.16万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9412238
• 关键词: Acute; Adolescent; Adopted; Adoption; Adult; Aerosols; Air; Air Pollutants; Area; Biological Markers; Blood; Blood Pressure; CD40 Ligand; Carbon Monoxide; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular Physiology; Chemicals; Child; Chronic; Chronic Disease; Cigarette; Clinical; Community Health; Consumption; Dangerousness; Electronic cigarette; Environmental Tobacco Smoke; Epithelial Cells; Exposure to; Fibrinogen; Flavoring; Fright; Future; Glycerol; Hand; Harm Reduction; Health; Heating; Home environment; Household; Individual; Lead; Lung diseases; Mainstreaming; Morbidity - disease rate; Nasal cavity; Nicotine; Oral cavity; P-Selectin; Particulate Matter; Physiological; Poison; Propylene Glycols; Public Health; Research; Research Design; Risk; Risk Factors; Smoke; Smoker; Source; Spirometry; System; Testing; Time; Tobacco; Tobacco smoking; Tobacco use; Trace Elements; Vascular Cell Adhesion Molecule-1; cardiovascular disorder risk; cigarette smoking; cigarette smoking; heart rate variability; indexing; intercellular cell adhesion molecule; mortality; non-smoking; policy implication; pollutant; pulmonary function; smoking cessation; tobacco exposure; transcriptomics; vaping

Abstract Electronic cigarettes (e-cigs), were introduced to the US market only 10 years ago, and are markedly different from traditional cigarettes. Traditional cigarettes contain tobacco and are smoked through combustion, thereby exposing the smoker and those nearby (secondhand smoke; SHS) to thousands of potentially dangerous tobacco and combustion-related agents. In contrast, E-cigs are “vaped” rather than smoked, and the resultant aerosols produced contain a far smaller number of potentially toxic chemicals, such as nicotine and flavorings, as well as byproducts caused by the heating of propylene glycol, and glycerin. Thus, they are widely believed and marketed as a safer alternative to cigarette smoking, yet the actual dangers posed by the use of these e- cigarettes remains largely unexplored. Many see the widespread adoption of this alternative nicotine delivery system as holding great promise in helping people quit or reduce cigarette use, and thus are seen as having profoundly positive effects as harm reduction agents. Others fear that their use may lead adolescents (the group most likely to begin using cigarettes) to transition from their use to the use of cigarettes. To date, missing from this debate is the potential biologic harm of mainstream and secondhand e-cig aerosols in homes where these agents are used, and how such exposure compares to mainstream and SHS from cigarettes. Our overall hypothesis is that e-cig vaping in homes leads to exposure to aerosols containing a number of pollutants and that this exposure is associated with decrements in cardiopulmonary function and increases in biomarkers for risk of future pulmonary and cardiovascular disease both in the e-cig vaper and non-smoking/non-vaping children and adults in such homes. Findings from this study will have very significant research and public health implications by enhancing understanding of the potential dangers of e-cigs, which are rapidly increasing in use and which many believe is a safe alternative to cigarette smoking and an aid to helping tobacco smoking cessation.

摘要