Air Quality, Child, and Adult Health in Homes Where E-Cigarettes Are Smoked

吸电子烟的家庭中的空气质量、儿童和成人健康

• 批准号: 9412238
• 负责人: Terry Gordon
• 金额: $ 50.16万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9412238
• 关键词: Acute; Adolescent; Adopted; Adoption; Adult; Aerosols; Air; Air Pollutants; Area; Biological Markers; Blood; Blood Pressure; CD40 Ligand; Carbon Monoxide; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular Physiology; Chemicals; Child; Chronic; Chronic Disease; Cigarette; Clinical; Community Health; Consumption; Dangerousness; Electronic cigarette; Environmental Tobacco Smoke; Epithelial Cells; Exposure to; Fibrinogen; Flavoring; Fright; Future; Glycerol; Hand; Harm Reduction; Health; Heating; Home environment; Household; Individual; Lead; Lung diseases; Mainstreaming; Morbidity - disease rate; Nasal cavity; Nicotine; Oral cavity; P-Selectin; Particulate Matter; Physiological; Poison; Propylene Glycols; Public Health; Research; Research Design; Risk; Risk Factors; Smoke; Smoker; Source; Spirometry; System; Testing; Time; Tobacco; Tobacco smoking; Tobacco use; Trace Elements; Vascular Cell Adhesion Molecule-1; cardiovascular disorder risk; cigarette smoking; cigarette smoking; heart rate variability; indexing; intercellular cell adhesion molecule; mortality; non-smoking; policy implication; pollutant; pulmonary function; smoking cessation; tobacco exposure; transcriptomics; vaping

Abstract Electronic cigarettes (e-cigs), were introduced to the US market only 10 years ago, and are markedly different from traditional cigarettes. Traditional cigarettes contain tobacco and are smoked through combustion, thereby exposing the smoker and those nearby (secondhand smoke; SHS) to thousands of potentially dangerous tobacco and combustion-related agents. In contrast, E-cigs are “vaped” rather than smoked, and the resultant aerosols produced contain a far smaller number of potentially toxic chemicals, such as nicotine and flavorings, as well as byproducts caused by the heating of propylene glycol, and glycerin. Thus, they are widely believed and marketed as a safer alternative to cigarette smoking, yet the actual dangers posed by the use of these e- cigarettes remains largely unexplored. Many see the widespread adoption of this alternative nicotine delivery system as holding great promise in helping people quit or reduce cigarette use, and thus are seen as having profoundly positive effects as harm reduction agents. Others fear that their use may lead adolescents (the group most likely to begin using cigarettes) to transition from their use to the use of cigarettes. To date, missing from this debate is the potential biologic harm of mainstream and secondhand e-cig aerosols in homes where these agents are used, and how such exposure compares to mainstream and SHS from cigarettes. Our overall hypothesis is that e-cig vaping in homes leads to exposure to aerosols containing a number of pollutants and that this exposure is associated with decrements in cardiopulmonary function and increases in biomarkers for risk of future pulmonary and cardiovascular disease both in the e-cig vaper and non-smoking/non-vaping children and adults in such homes. Findings from this study will have very significant research and public health implications by enhancing understanding of the potential dangers of e-cigs, which are rapidly increasing in use and which many believe is a safe alternative to cigarette smoking and an aid to helping tobacco smoking cessation.

摘要 电子烟（e-cigs）仅在10年前才进入美国市场，并且有明显的不同 传统香烟。传统的香烟含有烟草并且通过燃烧来抽吸，从而 使吸烟者和附近的人（二手烟; SHS）暴露于数千种潜在的危险物质中， 烟草和与燃烧有关的物质。相比之下，电子烟是“vaped”而不是吸烟， 所产生的气溶胶含有数量少得多的潜在有毒化学物质，如尼古丁和调味剂， 以及由丙二醇和甘油的加热引起的副产物。因此，他们被广泛认为 并作为吸烟的更安全替代品销售，但使用这些电子烟所造成的实际危险- 香烟在很大程度上尚未开发。许多人看到这种替代尼古丁输送的广泛采用 该系统在帮助人们戒烟或减少吸烟方面有很大的希望，因此被视为具有 作为减少危害的媒介，具有深远的积极影响。其他人担心，使用这些药物可能会导致青少年（ 最有可能开始使用香烟的群体）从使用香烟过渡到使用香烟。至今，失踪 从这场辩论是潜在的生物危害的主流和二手电子烟气溶胶在家庭， 这些试剂的使用，以及如何将这种暴露与主流和来自香烟的SHS进行比较。我们的整体 一种假设是，在家中使用电子烟会导致暴露于含有多种污染物的气溶胶中， 这种暴露与心肺功能的下降和生物标志物的增加有关， 电子烟和非吸烟/非vaping中未来肺和心血管疾病的风险 在这样的家庭里，孩子和大人。这项研究的结果将有非常重要的研究和公众 通过提高对电子烟潜在危险的认识，对健康的影响，电子烟的危险正在迅速增加 许多人认为它是吸烟的安全替代品，并有助于帮助吸烟 停止