Magnetoencephalography and Neurobehavioral Outcome of Pediatric Traumatic Brain Injury

脑磁图和小儿创伤性脑损伤的神经行为结果

• 批准号: 9308125
• 负责人: JEFFREY Edwin MAX
• 金额: $ 67万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-10 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9308125
• 关键词: 15 year old; Accidents; Adult; Age; Anisotropy; Area; Attention; Back; Behavior assessment; Behavioral; Brain; Brain Injuries; Characteristics; Child; Childhood; Childhood Injury; Cognition; Comorbidity; Control Groups; Controlled Study; Databases; Deafferentation procedure; Detection; Development; Diffusion Magnetic Resonance Imaging; Dose; Early identification; Event; Family; Fiber; Fostering; Functional Magnetic Resonance Imaging; Functional disorder; Generations; Goals; Image; Imaging Techniques; Injury; Investigation; Italy; Knowledge; Lesion; Life; Longitudinal prospective study; Magnetic Resonance Imaging; Magnetoencephalography; Mediating; Mental disorders; Methodology; Neurons; Neuropsychology; Orthopedics; Outcome; Outcome Study; Parietal; Participant; Patients; Pattern; Predisposing Factor; Problem behavior; Prospective Studies; Psychiatric therapeutic procedure; Psychosocial Factor; Public Health; Recording of previous events; Recovery; Recruitment Activity; Rehabilitation therapy; Reporting; Resolution; Rest; Risk Factors; Scanning; Sensitivity and Specificity; Severities; Short-Term Memory; Signal Transduction; Socioeconomic Status; Suggestion; Symptoms; Time; Traumatic Brain Injury; United States; axon injury; base; behavior measurement; behavioral study; brain dysfunction; cholinergic; cognitive function; coping; gray matter; healing; improved; indexing; injured; innovation; longitudinal design; mild traumatic brain injury; neurobehavior; neurobehavioral; neuroimaging; pediatric traumatic brain injury; prospective; psychological trauma; psychosocial; resilience; response; tool; transmission process; white matter

Traumatic brain injury (TBI) is a major public health problem in the United States. The application of magnetoencephalography (MEG) to the study of behavioral outcome of pediatric TBI is innovative because MEG may discern potential mechanisms for these outcomes. This potential derives from the fact that MEG is a functional neuroimaging tool that detects evidence of brain damage that eludes detection by MRI in the vast majority of cases of mild TBI and likely identifies additional lesions even in moderate to severe TBI. The goal of the proposed project is to study injury and psychosocial risk factors for the development of behavioral complications in children with TBI. The proposed study will involve a 3-month, 2-assessment, prospective longitudinal study of consecutively treated injured children with TBI (n=220) and a control group of children with orthopedic injuries (OI) not involving the brain (n=110). Assessments will include MEG and structural and functional MRI. Validated assessments of behavioral, psychiatric, neurobehavioral, and psychosocial variables will be administered. The study will examine 4 major hypotheses: (1) Abnormal slow-wave MEG activity and its reduction (healing) from 2 weeks to 3 months postinjury will occur in higher magnitude and in more brain areas in TBI versus OI children, and with greater severity of TBI. The younger the age of children with TBI the slower the recovery will be over time. (2) MEG will be more sensitive and specific than MRI in detecting damaged areas of brain and altered connectivity in children with TBI and OI. (3) Injury variables (age, MEG slow waves, FA, severity, MRI volumetric indices, presence of brain lesion) will mediate changes in postconcussion symptoms, occurrence of new-onset psychiatric disorders, and attention function changes and outcome in children with TBI and OI, independent of effects of preinjury child variables (adaptive, academic and cognitive function, and comorbid psychiatric disorders), postinjury child variables (adaptive function, coping), preinjury family variables (family function, socioeconomic status, life-events, family psychiatric history), and postinjury family variables (functioning). (4) Compared with OI, children with TBI will perform more poorly and improve less on an n-back working memory task, and demonstrate a different pattern of MEG signal activation suggestive of frontal- parietal dysfunction. This study will foster more accurate prediction, earlier identification and improved treatment of psychiatric and neurobehavioral complications related to pediatric TBI.

创伤性脑损伤（TBI）是美国一个主要的公共卫生问题。的应用