Developing and Evaluating Technology to Measure PAH Fate and Exposures

开发和评估测量 PAH 归宿和暴露的技术

• 批准号: 10573187
• 负责人: Kim A. Anderson
• 金额: $ 27.99万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573187
• 关键词: Address; Air; Aromatic Polycyclic Hydrocarbons; Atmosphere; Behavior; Biological; Biological Availability; Cell Culture Techniques; Characteristics; Chemical Exposure; Chemicals; Collaborations; Communities; Creosote; Data; Dependence; Devices; Environment; Exposure to; Geographic Factor; Hazardous Substances; Health; Hour; Housing; Human; Individual; Location; Lung; Measurement; Measures; Methods; Modeling; Movement; Pattern; Performance; Persons; Poison; Risk; Risk Assessment; Sampling; Seasonal Variations; Seasons; Signal Recognition Particle; Site; Superfund; System; Technology; Testing; Time; Toxic effect; Toxicity Tests; Translational Research; Variant; Water; Zebrafish; cost effective; daily functioning; effectiveness evaluation; meter; new technology; novel; remediation; sound; superfund site; tool

PROJECT SUMMARY – ANDERSON PROJECT Superfund site managers lack information that would allow them to select the most environmentally sound and cost-effective remediation strategies. To make a balanced decision, they must understand the behavior of the entire system: they need to know how toxic chemicals move into and out of the site, when and where those chemicals move. We propose to discover the fate of bioavailable PAH (polycyclic aromatic hydrocarbon), utilizing passive sampling devices (PSD) technologies, to assess bioavailable PAH flux between environmental compartments. We propose to develop generalizable technology to measure the movement (flux) of PAHs into and out of Superfund sites. We will determine how PAH movement varies with the seasons and tides. We will quantify the net movement of PAHs into the local environments via diffusive and advective flux in waters at different locations, at different times of the day, and in different seasons of the year. We propose to test these hypotheses: (1) The mass of bioavailable PAH movement between Superfund sediment-water and water- atmosphere interfaces varies as a function of location, season and tide and (2) The advective flux of bioavailable PAHs represents a significant fraction of the total PAH flux. We will deliver the first methods to concurrently quantify spatial and temporal movement of bioavailable PAHs to and from a Superfund site from sediment, water, and air. These methods will help EPA, remediators, and site managers to prioritize sites for remediation, optimize remediation strategies for their sites, and evaluate the effectiveness of those strategies. We propose to conduct the first passive sampling wristband measurements of external exposure to PAHs for people near Superfund sites. This will give stakeholders and communities a quantitative understanding of people's external exposure and its dependence on distance, geographic factors, housing, and personal characteristics. Will also test external exposure to PAHs for the same individuals after remediation. We propose to test these hypotheses: (3) In communities near Superfund sites, the magnitude of people's external wristband measured exposure depends on their distance to the site, their housing characteristics, and their time-activity patterns; and (4) Remediation of a Superfund site will diminish the community's external exposure to PAHs. We will also convey real-world chemical mixtures from the wristbands to Tanguay and Tilton, who will test the toxicity of the bioavailable mixtures in the zebrafish model and in human lung cell cultures. We will collaborate with them in effects-directed analyses to identify toxic components of the mixtures. In collaboration with the RT and CEC teams, we will describe to stakeholders and communities a) how external exposure to PAH mixtures varies as a function of location near a Superfund site, b) which components of the mixtures, if any, may threaten human health, and c) how remediation of a Superfund site influences the local community's external exposure to PAHs.

项目概要-安德森项目 超级基金场地经理缺乏信息，无法选择最环保的场地， 具有成本效益的补救战略。为了做出一个平衡的决定，他们必须了解 整个系统：他们需要知道有毒化学品如何进出现场，何时何地， 化学品移动我们建议发现生物可利用的PAH（多环芳烃）的命运， 利用被动采样装置（PSD）技术，评估环境之间的生物可利用的PAH通量 隔间我们建议开发可推广的技术来测量多环芳烃的移动（通量）， 从超级基金网站上下载我们将确定PAH运动如何随季节和潮汐而变化。我们将 通过沃茨中的扩散和平流通量，量化多环芳烃进入当地环境的净移动， 不同的地点，一天中的不同时间，以及一年中的不同季节。我们建议测试这些 假设：（1）生物可利用的PAH在超级基金沉积物-水和水-水之间的迁移量， 大气界面随位置、季节和潮汐的变化而变化;（2） 生物可利用的多环芳烃代表了总多环芳烃通量的重要部分。我们将提供第一个方法， 同时量化生物可利用的多环芳烃的空间和时间移动，并从超级基金网站， 沉积物水和空气这些方法将帮助EPA，补救人员和现场管理人员优先考虑现场， 补救，优化其网站的补救策略，并评估这些策略的有效性。 我们建议进行第一次被动采样腕带测量多环芳烃的外部暴露， 超级基金附近的人这将使利益相关者和社区对以下方面有一个定量的了解： 人们的外部暴露及其对距离、地理因素、住房和个人的依赖 特色补救后还将测试同一个人对多环芳烃的外部暴露情况。我们 我建议测试这些假设：（3）在超级基金网站附近的社区，人们的外部环境的大小， 腕带测量的暴露取决于他们到现场的距离，他们的住房特征， 时间-活动模式;及（4）超级基金场地的修复将减少社区的外部 暴露于PAH。我们还将把腕带中的真实化学混合物传送给坦盖， Tilton博士将在斑马鱼模型和人类肺细胞中测试生物可利用混合物的毒性 cultures.我们将与他们合作，进行以效果为导向的分析， 混合物。与RT和CEC团队合作，我们将向利益相关者和社区描述a） 多环芳烃混合物的外部暴露如何随超级基金场地附近位置的变化而变化，B） 混合物的成分，如果有的话，可能会威胁人类健康，以及c）如何补救超级基金网站 影响当地社区对多环芳烃的外部暴露。