Chemical Mixtures Core

岩心摘要-化学混合物岩心 超级基金场地含有多种污染物的混合物。美国环保署补充指导进行 《化学品健康风险评估》指出，“基于全部混合物的方法是可取的， 组成方法”。研究界需要适用于复杂分析的稳健、分析物丰富的方法。 矩阵科学界需要新的、专门的、更灵敏的方法来分离、检测和 量化数十种多环芳烃（PAH）和取代的PAH， 浓度和化学性质的复杂，异质矩阵。这些挑战继续 推动多环芳烃、取代多环芳烃和多环芳烃转化产物分析方法的发展， 以及超级基金共同污染物。对环境中多环芳烃和x-多环芳烃的分析要求很高， 生物基质，因为样品是复杂的，许多异构体的烷基化和高分子， 质量化合物往往难以区分，我们往往缺乏标准和适当的参考 材料.化学混合物核心（CMC）的主要目标是支持其他超级基金中心 项目和核心。我们将最大限度地使他们获得有质量保证的定量分析技术， 使他们能够增加他们的创造力和知识。我们将创造新的和改进的方法， 多环芳烃、多环芳烃代谢物和取代的多环芳烃（例如，烷基-、氧-和氮-取代的多环芳烃）。我们将 与数据管理和分析中心（DMAC）合作，改进我们独特的基于网络的界面 申请标准品、经认证的参考物质和提交样品。我们将开发和改进 我们的大容量数据生产和管理平台。我们将通过以下方式扩大1，530种分析物筛查 继续发展混合物分析的简化方法。我们将在现实世界中创造生物可利用的 与环境合作，从超级基金土壤、沉积物和水提取物中提取参考材料 项目，并将这些材料提供给生物项目。我们将提供基于网络的培训材料， 分析方法和生物分析技术，以中心研究人员和学员。

CORE SUMMARY – CHEMICAL MIXTURES CORE Superfund sites contain mixtures of many contaminants. The US EPA Supplemental Guidance for Conducting Health Risk Assessments of Chemicals stated that “approaches based on whole mixtures are preferred to component approaches”. The research community needs robust, analyte-rich methods suitable for complex matrixes. The scientific community needs new, specialized, more sensitive methods to separate, detect, and quantify dozens of polycyclic aromatic hydrocarbons (PAHs) and substituted PAHs with widely varying concentrations and chemical properties in complex, heterogeneous matrices. These challenges continue to drive the development of analytical methods for PAHs, substituted PAHs and PAH transformation products, as well as Superfund co-contaminants. It is demanding to analyze PAHs and x-PAHs in environmental and biological matrices because the samples are complex, the numerous isomers of alkylated and high-molecular- mass compounds are often difficult to differentiate, and we often lack standards and suitable reference materials. The primary goal of the Chemistry Mixtures Core (CMC) is to support other Superfund Center projects and cores. We will maximize their access to quality-assured quantitative analytical technologies and empower them to increase their creativity and knowledge. We will create new and improved methods for PAHs, PAH metabolites, and substituted PAHs (e.g., alkyl-, oxygen- and nitrogen- substituted PAHs). We will collaborate with the Data Management and Analysis Core (DMAC) to improve our unique web-based interface for requesting standards, certified reference materials and submitting samples. We will develop and improve our high-volume data production and management platform. We will expand the 1,530-analyte screen by continuing to develop reductionist methods for mixture analysis. We will create bioavailable real-world reference materials from Superfund soil, sediment and water extracts in collaboration with the environmental projects and provide these materials to the biological projects. We will provide web-based training material for analytical methods and bio-analytical technologies to center investigators and trainees.