Pathogenesis, Targeted Therapeutics, and New Vaccines for Childhood Disease

儿童疾病的发病机制、靶向治疗和新疫苗

• 批准号: 9217660
• 负责人: STEVEN A. WEBBER
• 金额: $ 34.57万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-08 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9217660
• 关键词: Aptitude; Area; Cancer Biology; Child health care; Childhood; Collaborations; Columbidae; Communicable Diseases; Core Facility; Coupled; Development; Diabetes Mellitus; Disease; Environment; Evaluation; Faculty; Funding; Generations; Goals; Grant; Group Meetings; Heart Diseases; Hospitals; International; Laboratory Research; Leadership; Lung diseases; Medical center; Mentors; Mentorship; Metabolism; Molecular; NCI Scholars Program; Obesity; Pathogenesis; Peer Group; Physicians; Positioning Attribute; Research; Research Personnel; Resources; SECTM1 gene; Scientist; Training; Training Programs; Underrepresented Minority; United States National Institutes of Health; Vaccines; cardiogenesis; career; career development; collaborative environment; laboratory facility; lung development; medical schools; meetings; multidisciplinary; nervous system disorder; next generation; novel therapeutics; novel vaccines; pediatric department; pediatrician; peer; premature; programs; targeted treatment; therapeutic target; therapeutic vaccine

 DESCRIPTION (provided by applicant): The goal of this new application is to establish at Vanderbilt a mentored training program for early career pediatricians possessing both the aptitude and passion to become a new generation of basic and translational physician scientists. The overarching theme for the program is elucidation of the molecular and cellular pathogenesis of childhood diseases, leading to identification of therapeutic targets for the development of new drugs, biologics and vaccines. We will focus on career development in the following areas of child health where Vanderbilt has internationally recognized programs of discovery combined with a record of sustained excellence in research mentorship, namely: 1) Lung Disease and Development, including lung disease of prematurity; 2) Heart Disease and Development; 3) Obesity and Metabolism (including diabetes) 4) Neurological Disorders; 5) Cancer Biology and 6) Infectious Diseases of Childhood. The program offers an integrated pediatric department and medical school training program for four pediatric K12 scholars to receive up to three years of support that includes intense scientific mentorship and personalized career development. The scholars will have access to a cadre of well-established faculty including 25 carefully selected basic and translational senior investigators with sustained NIH funding coupled with an extensive and successful track record of mentoring early career scholars. In addition, we have carefully selected 10 pediatric mentors-in- training, most with R01 funding that will be well positioned for full mentorship of K12 scholars at the completion of this cycle. The Department of Pediatrics is fully integrated into the Vanderbilt School of Medicine and Medical Center, which ranks in the top 10 in NIH funding. All academic departments, hospitals, research laboratories and core facilities reside on a single campus offering an integrated research environment for early career physician scientists. The Department currently has 6 T32 grants providing an existing pipeline of K12 scholars. The departmental leadership will also conduct a national search to identify a group of K12 scholars, including underrepresented minorities that will thrive in this highly collaborative environment. Each scholar will have an individualized training program developed by the program and training directors in collaboration with a multidisciplinary mentorship team and will be supported by a broad array of institutional and departmental resources. Each scholar will participate in regular peer-to-peer group meetings including twice-monthly career development seminars with other campus K-awardees, bi-weekly lunch meetings with the training directors alternating with bi-weekly K12 peer-to-peer `Work-in-Progress' meetings, weekly departmental research seminars, regular mentorship committees (at a minimum every 6 months), and annual formal evaluations of scholars and program. They will also have confidential face-to-face meetings with two outside advisors (former and current Pediatric Chairs, Drs. Arnold Strauss and George Dover). Taken together, these multiple efforts provide an optimal environment for developing the next generation of pediatric physician scientists.

 描述（由申请人提供）：这项新申请的目标是在范德比尔特大学为具有成为新一代基础和转化医师科学家的能力和热情的早期职业儿科医生建立一个指导培训计划。该计划的首要主题是阐明儿童疾病的分子和细胞发病机制，从而确定新药、生物制剂和疫苗开发的治疗靶点。我们将重点关注以下儿童健康领域的职业发展，范德比尔特在这些领域拥有国际公认的发现计划，并在研究指导方面保持着持续卓越的记录，即： 1) 肺部疾病和发育，包括早产儿肺部疾病； 2）心脏病与发育； 3) 肥胖和新陈代谢（包括糖尿病） 4) 神经系统疾病； 5) 癌症生物学和 6) 儿童传染病。该计划为四名儿科 K12 学者提供综合儿科和医学院培训计划，以获得长达三年的支持，包括密集的科学指导和个性化的职业发展。学者们将有机会接触到一支实力雄厚的教师队伍，其中包括 25 名精心挑选的基础和转化高级研究人员，他们拥有 NIH 的持续资助，并在指导早期职业学者方面拥有广泛而成功的记录。此外，我们还精心挑选了 10 名儿科培训导师，其中大多数都获得了 R01 资金，他们将在本周期完成后为 K12 学者提供全面指导。儿科完全并入范德比尔特医学院和医疗中心，该学院在 NIH 资助中排名前 10。所有学术部门、医院、研究实验室和核心设施都位于一个校园内，为早期职业医师科学家提供综合研究环境。该系目前拥有 6 项 T32 拨款，为 K12 学者提供了现有的渠道。部门领导层还将在全国范围内寻找一批 K12 学者，其中包括代表性不足的少数族裔，他们将在这个高度协作的环境中茁壮成长。每位学者都将拥有由项目和培训主管与多学科导师团队合作开发的个性化培训计划，并将得到广泛的机构和部门资源的支持。每位学者将参加定期的同行小组会议，包括与其他校园 K 获奖者举行的每月两次的职业发展研讨会、与培训主管每两周一次的午餐会议以及每两周一次的 K12 同行“正在进行的工作”会议、每周的部门研究研讨会、定期的指导委员会（至少每 6 个月一次）以及对学者和项目的年度正式评估。他们还将与两名外部顾问（前任和现任儿科主席阿诺德·施特劳斯博士和乔治·多佛博士）进行保密的面对面会议。总而言之，这些多项努力为培养下一代儿科医师科学家提供了最佳环境。