The Betel Nut Intervention Trial (BENIT)

槟榔干预试验（BENIT）

• 批准号: 9163071
• 负责人: THADDEUS A HERZOG
• 金额: $ 11.82万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9163071
• 关键词: Abstinence; Alcohols; Alkaloids; Areca; Asia; Behavioral; Biological Markers; Caffeine; Cancer Center; Carcinogens; Consumption; Data; Disease; Esophagus; Feasibility Studies; Fibrosis; Guam; Hawaii; Hour; International Agency for Research on Cancer; Intervention; Intervention Trial; Laboratories; Malignant neoplasm of pharynx; Mastication; Measures; Modeling; Nicotine; Nuts; Oral Leukoplakia; Outcome; Pacific Islands; Pamphlets; Participant; Patient Self-Report; Pilot Projects; Preparation; Prevalence; Randomized; Research; Saliva; Salivary; Sampling; Smoker; Southeastern Asia; Specific qualifier value; Study Section; Surveys; Testing; Treatment Efficacy; Universities; abstracting; base; carcinogenicity; efficacy testing; follow-up; liquid chromatography mass spectrometry; malignant mouth neoplasm; malignant oropharynx neoplasm; oral lesion; programs; psychologic; smoking cessation

Project Summary/Abstract Areca nut, also known as betel nut, is the fourth most commonly consumed psychoactive substance in the world, following only alcohol, nicotine, and caffeine in prevalence of consumption. Although betel nut is chewed by approximately 600 million people globally, its use is concentrated in South Asia, Southeast Asia, and some Pacific islands. Betel nut has been classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Betel nut chewing has been associated with oral and oropharyngeal cancer, oral lesions, oral leukoplakia, submucous fibrosis, gum disease, and cancer of the pharynx and esophagus. Despite the global significance and carcinogenicity of betel nut, there has been very little behavioral or psychological research about betel nut chewing, and there has been no systematic research on the topic of betel nut cessation interventions. The proposed research builds directly upon our prior research. Our survey data suggest that betel nut chewers, like smokers, generally want and intend to quit, but do not have specific plans of how or when they will quit. In addition, most betel nut chewers in our sample already have tried to quit on one or more occasions. These findings suggest that betel nut chewers could benefit from cessation programs modeled after smoking cessation programs. During 2014, we conducted a feasibility study of our betel nut cessation program. The program was well received and yielded surprisingly high rates of self- reported betel nut cessation. Our primary aim is to test the efficacy of an intensive group-based betel nut cessation program. Betel nut cessation will be bio-verified by employing biomarkers developed in our previous research. Participants (n=324) will be betel nut chewers from Guam and Saipan who are willing to attempt to quit chewing. Participants will be randomly assigned either to an intensive intervention condition or to a minimal intervention control condition. Participants in the intervention condition will receive a group-based cessation program consisting of five hour-long sessions over the span of 22 days, as well as a brochure with advice about quitting betel nut. Participants in the control condition will receive a brochure with advice about quitting betel nut. The proposed intervention trial will allow us to assess the 1-month and 6-month efficacy of the intervention compared to a minimal control intervention. We hypothesize that the intensive betel nut cessation intervention will produce a significantly greater cessation rate compared to the minimal control condition at the 6-month follow-up assessment.

项目总结/摘要 槟榔，也被称为槟榔，是世界上第四大最常食用的精神活性物质。 世界上，仅次于酒精，尼古丁和咖啡因的消费流行。槟榔虽嚼 全球约有6亿人使用，其使用集中在南亚，东南亚和一些 太平洋岛屿。槟榔已被国际原子能机构列为第一组致癌物质， 癌症研究。嚼槟榔与口腔癌、口咽癌、口腔病变、 口腔白斑、粘膜下纤维变性、牙龈疾病以及咽和食管癌。 尽管槟榔具有全球意义和致癌性，但很少有行为或 咀嚼槟榔的心理学研究，至今还没有系统的研究， 槟榔戒断干预措施。这项研究是在我们先前的研究基础上进行的。我们的调查 数据显示，嚼槟榔者和吸烟者一样，一般都想戒烟，但没有具体的戒烟计划。 如何或何时退出的计划。此外，在我们的样本中，大多数槟榔咀嚼者已经试图戒烟 一次或多次。这些发现表明，槟榔咀嚼者可以受益于戒烟 以戒烟计划为蓝本的计划。在2014年，我们进行了可行性研究， 槟榔戒食计划。该计划受到好评，并产生了令人惊讶的高利率的自我- 报告了槟榔的停止。 我们的主要目的是测试一个密集的小组为基础的槟榔戒烟计划的疗效。槟榔 我们会采用以往研究所发展的生物标记，对戒烟进行生物验证。参与者 （n=324）将是来自关岛和塞班岛的槟榔咀嚼者，他们愿意尝试停止咀嚼。 参与者将被随机分配到强化干预条件或最小干预条件 控制条件干预条件下的参与者将接受基于小组的戒烟计划 包括22天内5个小时的会议，以及一本关于戒烟建议的小册子 槟榔。对照组的参与者将收到一本小册子，上面有关于戒烟槟榔的建议。的 拟议的干预试验将使我们能够评估1个月和6个月的干预效果 与最小的控制干预相比。我们假设强化槟榔戒断干预 与6个月时的最低控制条件相比， 后续评估。