Imaging CAncer Screening Patch (CASP) for early diagnostics of cervical cancers

用于宫颈癌早期诊断的成像癌筛查贴片 (CASP)

• 批准号: 9316232
• 负责人: TOMASZ S TKACZYK
• 金额: $ 17.44万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316232
• 关键词: Address; Age; Algorithms; Area; Biopsy; Caliber; Cancer Detection; Cervical; Cervical Cancer Screening; Cervical dysplasia; Cervix Uteri; Clinical Cancer Center; Clinical Research; Collaborations; Colposcopy; Country; Cytology; Development; Devices; Diagnosis; Diagnostic; Dysplasia; Educational Status; Endoscopes; Feasibility Studies; Foundations; Future; Generations; Goals; Health care facility; Human Papilloma Virus Vaccination; Human Papillomavirus; Human Resources; Human papilloma virus infection; Image; Image Analysis; Imaging Device; Incidence; Income; Individual; Infection; Loop electrosurgical excision procedure; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Maps; Medically Underserved Area; Microinvasive; Monitor; Nuclear; Optics; Output; Pap smear; Pathology; Patients; Performance; Pilot Projects; Preventive vaccine; Procedures; Protocols documentation; Recording of previous events; Research; Research Infrastructure; Resolution; Resources; Rice; Rotation; Sampling; Screening for cancer; Screening procedure; Secondary Prevention; Series; Shapes; Solid; Specimen; Surface; System; Testing; Time; Tissue Model; Tissue imaging; Tissues; Training; Translating; Vaccines; Visit; Woman; Work; boys; cancer imaging; cellular imaging; cost; data acquisition; design; experience; flexibility; follow-up; girls; high risk; image processing; imaging system; insight; instrument; low and middle-income countries; mortality; novel diagnostics; point-of-care diagnostics; programs; prototype; response; screening; tool; uptake

Imaging CAncer Screening Patch (CASP) for early diagnostics of cervical cancers The work pursued within this proposal will carry out the feasibility studies to develop a new class of high resolution, non-invasive, optical multi-field of view, flexible surface imaging devices for cervical cancer detection and screening. The device is a response for an unmet crucial need of a lack of point-of-care diagnostic tools for cervical dysplasia and cancer in patients with an abnormal screening Pap and/or HPV test. The proposed tool called Cancer Screening Patch or CASP will be capable of providing pathology level resolution over large areas of tissue and therefore can become an effective diagnostic instrument. To simplify the screening procedure the system will be merged with image analysis tools to provide objective parameters like nuclear to cytoplasmic ratio (NCR) and allow screening by low/medium training level personnel. The initial results will be available within minutes, allowing for a “Screen & Treat” approach and eliminating the need for pathology review and associated wait times and additional return visits. The core idea of the approach is combining high resolution micro-endoscopes into multi-point flexible imaging patch array conforming to the shape of cervix and providing high sampling map available for numerical analysis. Specifically we will develop prototypes of CASP capable of sub-cellular imaging resolution over large tissue areas with image sampling of 2-4 microns at 100-150 FOVs. The target individual probing areas will have diameter of 200-450 microns and will be densely populated over imaged tissue and converged into a single camera output. In parallel we will develop effective analysis tools to provide objective assessment parameters like nuclear to cytoplasmic ratio, NCR thresholding and border delineation. To further increase imaged area and resolution, the probe can be linearly or rotationally shifted and imaged zones will be merged with mosaicking algorithms. Finally we will evaluate system imaging performance using both tissue models as well as ex-vivo LEEP specimens from 20 patients with a high- grade dysplasia in a pilot clinical study.

用于宫颈癌早期诊断的成像癌筛查贴片（CASP） 本提案中的工作将进行可行性研究， 一类高分辨率、非侵入式、光学多视场、柔性表面成像 用于宫颈癌检测和筛查的设备。该设备是对未满足的 缺乏宫颈不典型增生和宫颈癌的即时诊断工具的迫切需要， 筛查Pap和/或HPV检测异常的患者。被称为癌症的工具 筛选贴片或CASP将能够提供病理水平的分辨率， 因此可以成为一种有效的诊断工具。简化 筛选程序的系统将与图像分析工具，以提供客观的 参数如核质比（NCR），并允许通过低/中筛选 培训水平人员。初步结果将在几分钟内公布， “筛查和治疗”方法，消除了病理检查和相关等待的需要 时间和额外的回访。该方法的核心思想是将高分辨率 显微内窥镜到多点柔性成像贴片阵列符合的形状 并提供了高采样率的数字分析图。 具体来说，我们将开发CASP的原型，能够亚细胞成像分辨率 在100-150 FOV下的2-4微米的图像采样。目标 各个探测区域将具有200-450微米的直径，并且将是密集的 在成像的组织上并会聚成单个相机输出。与此同时，我们将开发 有效的分析工具，提供客观的评估参数，如核， 细胞质比率、NCR阈值和边界描绘。为了进一步增加成像面积 和分辨率，探头可以线性或旋转移位， 与镶嵌算法相结合。最后，我们将评估系统成像性能 使用这两种组织模型以及来自20名高血压患者的体外LEEP标本， 在一项初步临床研究中，