Miniature Foveated Endoscope for Early Cancer Diagnostics
用于早期癌症诊断的微型中央凹内窥镜
基本信息
- 批准号:8445549
- 负责人:
- 金额:$ 19.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-30 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:AchievementAdoptedArchitectureAreaCaliberCancer DiagnosticsCellular MorphologyClinicalComplementConfocal MicroscopyDataDetectionDevelopmentDevicesDiagnosticDiagnostic Neoplasm StagingDiamondEndoscopesEndoscopyEngineeringEyeFeedbackFluorescenceFoundationsGastroenterologistGoalsHumanImageImageryImaging DeviceImaging technologyInjection of therapeutic agentMalignant NeoplasmsMethodsMicroscopeMicroscopyMoldsMotivationOpticsPathologistPatientsPerformancePeripheralPrincipal InvestigatorPrintingPublishingResearch Project GrantsResolutionResourcesRiskRoleScanningScreening for cancerSpecimenSurfaceSurgical OncologistSystemTechnologyTissuesTranslatingValidationVisible RadiationWorkbaseclinically relevantcostdesignexperienceimaging modalityin vivoinnovationinstrumentinterestminiaturizenoveloptical imagingprototypetime orientationtissue phantom
项目摘要
DESCRIPTION (provided by applicant): The goal of this project is to demonstrate the feasibility of a novel endoscopic imaging method based on foveated imaging with additional capabilities for optical sectioning in the central portion of the field of view (FOV). This will alow practical implementation of endo-microscopy in the clinical arena, greatly augmenting diagnostic capabilities for early cancer detection. The device proposed here combines capabilities of a standard endoscope objective and endo- microscope. The objective will image a 5 mm diameter FOV with resolution spanning from 1.5 micron in the center of the field decreasing to 25 microns at the peripheral edges of the field. The resolution within the 5 mm FOV will be changing continuously, in a similar way to that achieved by the human eye (where the best resolution is in the center and degrades on periphery). In result a high resolution will be obtained in the central 500 micron field area. In addition optical sectioning capabilities using fluorescence confocal microscopy will be available at the center of the FOV. Therefore the proposed optical system is envisioned to enable a seamless transition from the wide-field imaging configuration to the confocal imaging configuration in a wide variety of endoscopic imaging applications. Importantly, the lower resolution image of the tissue surface will be available at all times for orientation and
identification of regions of interest. The project consists of two specific aims. They focus on (1)
development of the optical-design, fabrication and assembly of the foveated miniature optical systems and (2) objective validation for phantom and tissue imaging to obtain clinician feedback.
PUBLIC HEALTH RELEVANCE: The project targets the development of an innovative, foveated optical system for use in the detection of precancer by endoscopy and endomicroscopy. The proposed device combines two distinct imaging methods: an endoscope with a wide field of view and resolution that allows visualization of microvasculature and an endomicroscope with a co-registered small field of view and cellular and subcellular detail made visible by a fluorescence confocal microscopy. With the proposed technology, clinicians will be able to more effectively screen patients for early indications of cancer. Furthermore, the optical-imaging technology whose development is proposed here is a strong candidate for a low- cost manufacturing and thus enabling wide instrument accessibility.
描述(由申请人提供):本项目的目标是证明一种基于中心凹成像的新型内窥镜成像方法的可行性,该方法具有在视野(FOV)中心部分进行光学切片的额外功能。这将允许在临床竞技场中实际实施内窥镜检查,大大增强早期癌症检测的诊断能力。这里提出的装置结合了标准内窥镜物镜和内窥镜显微镜的能力。物镜将对直径为5 mm的FOV成像,分辨率从视场中心的1.5微米降至视场周边的25微米。5 mm FOV内的分辨率将以与人眼所实现的方式类似的方式连续变化(其中最佳分辨率在中心并且在外围降级)。结果,在中心500微米场区域中将获得高分辨率。此外,使用荧光共聚焦显微镜的光学切片功能将在FOV的中心提供。因此,设想所提出的光学系统能够在各种各样的内窥镜成像应用中实现从宽视场成像配置到共焦成像配置的无缝过渡。重要的是,组织表面的较低分辨率图像将始终可用于定向和定位。
识别感兴趣的区域。该项目包括两个具体目标。重点在于(1)
光学设计的发展,小凹微型光学系统的制造和组装,以及(2)对体模和组织成像的客观验证,以获得临床医生的反馈。
公共卫生相关性:该项目的目标是开发一种创新的、有中央凹的光学系统,用于通过内窥镜和显微内镜检测癌前病变。所提出的设备结合了两种不同的成像方法:具有宽视场和分辨率的内窥镜,其允许微血管的可视化,以及具有共同配准的小视场的显微内镜,以及通过荧光共聚焦显微镜可见的细胞和亚细胞细节。有了这项技术,临床医生将能够更有效地筛查癌症的早期迹象。此外,光学成像技术的发展,在这里提出的是一个强有力的候选人的低成本制造,从而使广泛的仪器可访问性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
TOMASZ S TKACZYK其他文献
TOMASZ S TKACZYK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('TOMASZ S TKACZYK', 18)}}的其他基金
Light-guide Image Processing (LIP) 3D printed snapshot spectrometer for molecular imaging
用于分子成像的光导图像处理 (LIP) 3D 打印快照光谱仪
- 批准号:
10447267 - 财政年份:2022
- 资助金额:
$ 19.57万 - 项目类别:
Light-guide Image Processing (LIP) 3D printed snapshot spectrometer for molecular imaging
用于分子成像的光导图像处理 (LIP) 3D 打印快照光谱仪
- 批准号:
10613348 - 财政年份:2022
- 资助金额:
$ 19.57万 - 项目类别:
Imaging CAncer Screening Patch (CASP) for early diagnostics of cervical cancers
用于宫颈癌早期诊断的成像癌筛查贴片 (CASP)
- 批准号:
9316232 - 财政年份:2017
- 资助金额:
$ 19.57万 - 项目类别:
Adaptive Miniature Microscopy Platform for High Throughput Biological Imaging
用于高通量生物成像的自适应微型显微镜平台
- 批准号:
8840586 - 财政年份:2014
- 资助金额:
$ 19.57万 - 项目类别:
Adaptive Miniature Microscopy Platform for High Throughput Biological Imaging
用于高通量生物成像的自适应微型显微镜平台
- 批准号:
8638575 - 财政年份:2014
- 资助金额:
$ 19.57万 - 项目类别:
Miniature Foveated Endoscope for Early Cancer Diagnostics
用于早期癌症诊断的微型中央凹内窥镜
- 批准号:
8549922 - 财政年份:2012
- 资助金额:
$ 19.57万 - 项目类别:
Image Slicing Spectrometer (ISS) for high resolution sub-cellular microscopy
用于高分辨率亚细胞显微镜的图像切片光谱仪 (ISS)
- 批准号:
7695567 - 财政年份:2008
- 资助金额:
$ 19.57万 - 项目类别:
Image Slicing Spectrometer (ISS) for high resolution sub-cellular microscopy
用于高分辨率亚细胞显微镜的图像切片光谱仪 (ISS)
- 批准号:
7572583 - 财政年份:2008
- 资助金额:
$ 19.57万 - 项目类别:
Integrated Bi-FOV Endoscope for Detection of Precancer
用于检测癌前病变的集成双视场内窥镜
- 批准号:
7661361 - 财政年份:2007
- 资助金额:
$ 19.57万 - 项目类别:
Integrated Bi-FOV Endoscope for Detection of Precancer
用于检测癌前病变的集成双视场内窥镜
- 批准号:
7502715 - 财政年份:2007
- 资助金额:
$ 19.57万 - 项目类别:
相似海外基金
How novices write code: discovering best practices and how they can be adopted
新手如何编写代码:发现最佳实践以及如何采用它们
- 批准号:
2315783 - 财政年份:2023
- 资助金额:
$ 19.57万 - 项目类别:
Standard Grant
One or Several Mothers: The Adopted Child as Critical and Clinical Subject
一位或多位母亲:收养的孩子作为关键和临床对象
- 批准号:
2719534 - 财政年份:2022
- 资助金额:
$ 19.57万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633211 - 财政年份:2020
- 资助金额:
$ 19.57万 - 项目类别:
Studentship
A material investigation of the ceramic shards excavated from the Omuro Ninsei kiln site: Production techniques adopted by Nonomura Ninsei.
对大室仁清窑遗址出土的陶瓷碎片进行材质调查:野野村仁清采用的生产技术。
- 批准号:
20K01113 - 财政年份:2020
- 资助金额:
$ 19.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2436895 - 财政年份:2020
- 资助金额:
$ 19.57万 - 项目类别:
Studentship
A comparative study of disabled children and their adopted maternal figures in French and English Romantic Literature
英法浪漫主义文学中残疾儿童及其收养母亲形象的比较研究
- 批准号:
2633207 - 财政年份:2020
- 资助金额:
$ 19.57万 - 项目类别:
Studentship
The limits of development: State structural policy, comparing systems adopted in two European mountain regions (1945-1989)
发展的限制:国家结构政策,比较欧洲两个山区采用的制度(1945-1989)
- 批准号:
426559561 - 财政年份:2019
- 资助金额:
$ 19.57万 - 项目类别:
Research Grants
Securing a Sense of Safety for Adopted Children in Middle Childhood
确保被收养儿童的中期安全感
- 批准号:
2236701 - 财政年份:2019
- 资助金额:
$ 19.57万 - 项目类别:
Studentship
A Study on Mutual Funds Adopted for Individual Defined Contribution Pension Plans
个人设定缴存养老金计划采用共同基金的研究
- 批准号:
19K01745 - 财政年份:2019
- 资助金额:
$ 19.57万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structural and functional analyses of a bacterial protein translocation domain that has adopted diverse pathogenic effector functions within host cells
对宿主细胞内采用多种致病效应功能的细菌蛋白易位结构域进行结构和功能分析
- 批准号:
415543446 - 财政年份:2019
- 资助金额:
$ 19.57万 - 项目类别:
Research Fellowships