Improving the Safety and Efficacy of Intraventricular Neurosurgery via Robotics
通过机器人技术提高脑室内神经外科手术的安全性和有效性
基本信息
- 批准号:9383804
- 负责人:
- 金额:$ 53.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2021-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAlgorithm DesignAlgorithmsAnimal ExperimentsAnimalsBlood VesselsBrainBrain NeoplasmsCauterizeCavernous HemangiomaCerebral VentriclesComplexDissectionEffectivenessEndoscopesEndoscopyEpilepsyExcisionGliomaGoalsHamartomaHandHemorrhageHydrocephalusImageImageryIn SituInjuryIntraventricularIntuitionIrrigationJoystickLengthLength of StayLesionLiftingLiquid substanceLocationMagnetic Resonance ImagingMediationMedicalMicroscopyMicrosurgeryMonitorMorbidity - disease rateNeuroendoscopesNeurologic DeficitNeurosurgeonNeurosurgical ProceduresOperative Surgical ProceduresOutcomePineal Region TumorProceduresPublished CommentRehabilitation therapyResidual TumorsResidual stateRiskRobotRoboticsSafetySeriesShapesSiteStructureSuctionSurgeonSurgical InstrumentsSystemTechniquesTechnologyTendon structureTimeTissuesTraumaTubeVentricularVisionarmbrain surgerybrain tissuecostdesigndexterityergonomicsflexibilityhand grasphigh riskimprovedin vivoinjuredinstrumentminimally invasiveneurosurgeryneurovascularoperationtargeted imagingtooltumor
项目摘要
Project Summary
Out of over 380,000 brain surgeries performed in the USA every year, at least 20% are to remove lesions located
inside or adjacent to the brain’s ventricles, i.e., cavities filled with clear fluid. Using endoscopes, neurosurgeons
can navigate their instruments through the ventricles to reach these lesions with less damage to healthy brain
tissue than occurs in open surgery. Current endoscopes, however, are restricted by three main factors which
limit their use to about 5% of the potential cases (1% of all brain surgeries). First, endoscopes have tools
emerging parallel to the working shaft, precluding many of the two-handed surgical techniques of open surgery
that are used to dissect tissue and stop bleeding. Second, most neurosurgeons use straight rigid endoscopes
that cannot negotiate around corners without causing significant brain retraction injury. Third, there is a risk of
leaving behind significant residual tumors and also injuring critical neurovascular structures that are not directly
in the line of sight. The first two problems can be solved by providing two dexterous arms at the tip of endoscope
and by enabling easily controllable steerability for navigating around corners. The third issue can be addressed
by intraoperative MR imaging, with the added benefit of real-time imaging of the target lesion throughout the
operation. Currently, however, intraoperative MRI is limited to open surgery and allows only intermittent imaging
due to MR-incompatibility of standard surgical instruments as well as the difficult ergonomics of operating inside
a scanner. The project goal is to create robotic endoscopes for use inside an MR scanner. These surgeon-
controlled instruments will enable intuitive steering through the ventricles to the site of a lesion. There, two tip-
mounted dextrous arms can be deployed for bimanual lesion resection under combined endoscopic and MR
visualization. It is anticipated that these systems will enable endoscopic resection of 50% of lesions inside and
adjacent to the ventricles (10% of all intracranial lesions) while also improving the safety and efficacy of current
endoscopic procedures – resulting in a 10-fold increase in the number of brain surgeries that can be treated
endoscopically. Aim I will create a straight MRI-compatible bimanual neuroendoscope with two dexterous arms
comprised of telescoping elastic tubes. Aim II will offer a longer curvilinear surgical trajectory to deeper
ventricular and periventricular lesions by integrating a telescoping tendon-drive technology for endoscope
steerability with the tip-mounted arms of Aim 1. Both systems will be evaluated and refined through a series of
phantom and animal studies. The project leaders are experts in neuroendoscopic surgery, MRI-compatible
technologies and medical robot design.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Pierre E Dupont', 18)}}的其他基金
Removable airway stents that preserve mucociliary function
保留粘膜纤毛功能的可拆卸气道支架
- 批准号:
10258203 - 财政年份:2021
- 资助金额:
$ 53.75万 - 项目类别:
Improving the Safety and Efficacy of Intraventricular Neurosurgery via Robotics
通过机器人技术提高脑室内神经外科手术的安全性和有效性
- 批准号:
9908191 - 财政年份:2017
- 资助金额:
$ 53.75万 - 项目类别:
In Vivo Molding of Airway Stents Optimized to Preserve Ciliary Function for Neonates and Infants
优化气道支架体内成型以保护新生儿和婴儿的纤毛功能
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9317819 - 财政年份:2017
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Cardioscopically-guided Valve Repair in the Beating Heart
心镜引导下跳动心脏瓣膜修复
- 批准号:
10853545 - 财政年份:2014
- 资助金额:
$ 53.75万 - 项目类别:
Cardioscopically-guided Bimanual Valve Repair in the Beating Heart
心镜引导下跳动心脏的双手瓣膜修复术
- 批准号:
9110350 - 财政年份:2014
- 资助金额:
$ 53.75万 - 项目类别:
Cardioscopically-guided Valve Repair in the Beating Heart
心镜引导下跳动心脏瓣膜修复
- 批准号:
10211326 - 财政年份:2014
- 资助金额:
$ 53.75万 - 项目类别:
Cardioscopically-guided Valve Repair in the Beating Heart
心镜引导下跳动心脏瓣膜修复
- 批准号:
10414058 - 财政年份:2014
- 资助金额:
$ 53.75万 - 项目类别:
Cardioscopically-guided Valve Repair in the Beating Heart
心镜引导下跳动心脏瓣膜修复
- 批准号:
10600060 - 财政年份:2014
- 资助金额:
$ 53.75万 - 项目类别:
Steerable MEMS Instruments for Precise Intracardiac Surgery
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7236533 - 财政年份:2007
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$ 53.75万 - 项目类别:
Steerable MEMS Instruments for Precise Intracardiac Surgery
用于精确心内手术的可操纵 MEMS 仪器
- 批准号:
7619500 - 财政年份:2007
- 资助金额:
$ 53.75万 - 项目类别:
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