Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

描述（由申请人提供）：这是密歇根大学Claude D. Pepper老年美国人独立中心（UM Pepper中心）的竞争性续期申请。UM胡椒中心的具体目标是：1)支持研究，以提高对代谢因素和炎症如何与年龄相关疾病和合并症相互作用的理解，以确定与活动能力和功能状态相关的关键健康结果。2)支持代谢因子和炎症与年龄相关疾病和合并症相互作用的转化研究，以改善与活动能力和功能状态相关的健康结局。为了实现这一目标，UM胡椒中心将与其他UM项目密切合作，包括美国国立卫生研究院资助的密歇根临床与健康研究所（MICHR）， UM临床和转化科学奖（CTSA）的所在地。3)提供资源核心，支持和协助研究人员发起的与UM胡椒中心研究重点相关的项目。4)通过其研究职业发展核心（RCDC），加强UM培养未来老年医学和老龄化学术领袖的环境，他们可以进行与UM胡椒中心研究重点相关的研究。5)通过其试点和探索性研究核心（PESC），吸引澳大初级教师，以及之前未参与老龄化研究的精选高级教师，开发与澳大胡椒中心研究重点相关的新研究项目。亚利桑那大学胡椒研究中心，现在是连续获得NIA资助的第25个年头，已经建立了一个完善的领导和行政结构，一个RCDC，一个PESC和四个rc：人类受试者和评估核心（HSAC）；生物力学核心（BC）；方法论、数据管理和分析核心（MDMAC）；以及老年啮齿动物核心设施（CFAR）。RCDC有三个核心要素：1)一个竞争性项目，每年选择2名有前途的澳大初级教师，使用kl2机制进行与澳大胡椒中心研究重点相关的研究，以保证75%的研究事业发展；2)为从事此类研究的初级教师提供全国认可的研究培训计划；3)为初级教师提供与一名或多名澳大高级研究员密切合作的机会的导师计划。PESC通过严格的外部审查，每年将资助4个或更多的试点项目。研究中心将支持多个外部资助项目、胡椒中心试点拨款和RCDC初级教员，并继续开发和测试胡椒中心研究中使用的新方法。

DESCRIPTION (provided by applicant): This is a competing renewal application for the Claude D. Pepper Older Americans Independence Center at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center is: 1) to support research that will improve understanding of how metabolic factors and inflammation interact with age related diseases and comorbidities to determine key health outcomes related to mobility and functional status. 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve this aim, the UM Pepper Center will work closely with other UM programs including the NIH funded Michigan Institute for Clinical and Health Research (MICHR), the home of the UM's Clinical and Translational Science Award (CTSA). 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center's research focus. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center's research focus. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty, as well as selected senior faculty not previously involved in aging research, to develop new research projects related to the UM Pepper Center's research focus. The UM Pepper Center, now in its 25th year of continuous NIA funding, has in place a well-established leadership and administrative structure, an RCDC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents(CFAR). The RCDC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center's research focus using the KL2mechanism to guarantee 75% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC, through rigorous external review, will fund 4 or more pilot projects per year. The RC's will support multiple externally funded projects, the Pepper Center pilot grants and RCDC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.