Human Subjects and Assessment Core

摘要 密歇根大学人类科目和评估核心(HSAC)提供基础设施和 对UM OAIC研究人员进行临床和转化性研究至关重要的资源。HSAC密切关注 与UM OAIC将BASE、临床和结果研究与临床实践相结合的目标保持一致。通过 卫生统筹委员会与拉丁美洲及加勒比地区、区域经济合作及教育统筹委员会和其他三个资源中心紧密合作，将协助亚洲及太平洋区域中心- 资助的试点项目和其他与伊斯兰会议组织中心研究主题有关的外部资助项目。 HSAC的重要优先事项将是支持新接触老龄化研究的初级教员，翻译BASIC 将研究发现转化为人体研究，并支持具有以下前景的高影响临床试验 减少老年人的残疾和改善身体/认知功能。HSAC的具体目标 1.促进研究人员获取人体受试者和相关数据集 与伊斯兰会议中心主题有关；2.就问题向伊斯兰会议组织的研究人员提供培训和咨询 与实验设计(获奖前和获奖后)、招募/保留人体受试者有关，翻译自 将动物纳入人体研究，比较国家数据库的技术；3.扩大和促进关于 影响易感因素、代谢/炎症介质的种族、民族和文化影响，以及 老年人的功能和健康结果；4.加强社区对老龄化研究和 促进在当地社区和学术界传播OAIC研究成果。

Abstract The University of Michigan Human Subjects and Assessment Core (HSAC) provides the infrastructure and resources critical to UM OAIC investigators performing clinical and translational research. The HSAC is closely aligned with the UM OAIC’s goal of integrating bench, clinical and outcome research with clinical practice. By working closely with the LAC, REC, PESC and the three other Resource Cores, the HSAC will assist OAIC- funded pilots and other externally funded projects (EPs) related to the central research theme of the OAIC. Important priorities for the HSAC will be to support junior faculty new to aging research, the translation of basic research discoveries into human studies, and to support high impact clinical trials that have the promise of reducing disability and improving physical/cognitive function in older adults. The Specific Aims of the HSAC are: 1. To facilitate access to human subjects and related data sets by investigators implementing research related to the central OAIC theme; 2. To provide training and consultation to OAIC researchers on issues related to experimental design (pre- and post-award), recruitment/retention of human subjects, translation from animal into human studies, techniques to compare national databases; 3. To expand and promote research on racial, ethnic, and cultural influences affecting the predisposing factors, metabolic/inflammatory mediators, and functional and health outcomes in older adults; 4. To enhance community engagement in aging research and facilitate the dissemination of OAIC research in the local community as well as the academic community.