PILOT AND EXPLORATORY STUDIES CORE

试点和探索性研究核心

• 批准号: 7802710
• 负责人: RAYMOND L YUNG
• 金额: $ 25.83万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7802710
• 关键词: Age; Aging; Aging-Related Process; Alcohol consumption; American; Animal Model; Applications Grants; Area; Award; Biological Factors; Chemistry; Comorbidity; Dependence; Discipline; Disease; Elderly; Environment; Ethnic group; Experimental Models; Extramural Activities; Factor Analysis; Faculty; Funding; Future; Gender; Genetic; Genetic Markers; Geriatrics; Gerontology; Goals; Grant; Group Identifications; Guidelines; Health; Health Services Research; Human; Impairment; Individual; Institution; Insulin; Investigation; Life; Manuscripts; Mentorship; Michigan; Mus; Muscle; Mutant Strains Mice; Pattern; Peer Review; Phenotype; Physiology; Pilot Projects; Population; Publishing; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Resources; Risk; Rodent; Science; Scientific Evaluation; Series; System; Testing; Training and Infrastructure; Universities; Work; age related; behavioral health; blood glucose regulation; bone; career development; design; falls; flexibility; frailty; genetic analysis; improved; in vitro Model; insulin sensitivity; member; mouse model; programs; ranpirnase; research and development; research study; response; social; symposium; therapy design; tool

The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center's overall theme, the predictors and modulators of the aging phenotype and the ways in which genetic, environmental, and social factors influence late life disease through effects on the aging process. The PESC will thus fund pilot research studies over a wide range of disciplines, ranging from basic genetics and physiology through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least two external reviewers, and then be further evaluated by OAIC leaders for its relevance to Center objectives. The Pepper Center's former Research Development Core (REIC) has made 61 pilot grant awards since its inception in 1989, mostly to junior faculty members, many of whom have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Four projects have been selected for funding in the 2004 - 2005 academic year, including studies of (a) the genetics of bone chemistry and fragility; (b) a new system for investigation of insulin sensitivity using muscle explants; (c) factors modifying risk of falls in frail and healthy elderly subjects; and (d) the influences of gender and ethnic group on trajectories of alcohol consumption. The PESC will be directed by Dr. Richard Miller, who has served as director of the OAIC's RDC since 1993, and will be co-directed by Dr. Jeffrey Halter. Drs. Miller and Halter will work closely with the Directors of the RCDC to assist RCDC junior faculty as they develop plans for competitive Pilot Grant applications for PESC consideration.

试点和探索性研究核心（PESC）的目标是为将开发的研究提供支持。 并测试与中心整体主题高度相关的新研究思路，预测和调节 衰老表型以及遗传、环境和社会因素影响晚年生活的方式 通过对衰老过程的影响而导致疾病。因此，PESC将资助广泛的试点研究。 一系列学科，从基础遗传学和生理学到行为和健康服务 research.每个提交的提案将首先接受至少两个外部专家的科学价值评估。 评审员，然后由OAIC领导进一步评估其与中心目标的相关性。花椒 中心的前研究发展核心（REIC）自成立以来，已经取得了61个试点赠款奖， 1989年，主要是初级教师，其中许多人现在已经建立了自己的生产力 老年医学和相关学科的独立研究人员。四个项目已被选中， 2004 - 2005学年的资助，包括（a）骨化学遗传学和 脆性;（B）使用肌肉外植体研究胰岛素敏感性的新系统;（c）改变胰岛素敏感性的因素 （d）性别及种族对身体虚弱及健康长者跌倒福尔斯的影响 酒精消费的轨迹PESC将由理查德米勒博士指导，他曾担任 自1993年以来一直担任OAIC的RDC主任，并将由Jeffrey Halter博士共同指导。米勒和哈尔特医生 将与RCDC主任密切合作，协助RCDC初级教师制定计划， 有竞争力的试点补助金申请PESC考虑。