Claude D. Pepper Older Americans Independence Centers (OAICs)(P30)

克劳德·D·佩珀美国老年人独立中心 (OAIC)(P30)

• 批准号: 10026914
• 负责人: RAYMOND L YUNG
• 金额: $ 134.77万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10026914
• 关键词: Academy; Activities of Daily Living; Address; Aging; American; Basic Science; Biomechanics; Biostatistics Core; Capsicum; Caring; Chronic Disease; Clinical; Clinical Research; Clinical and Translational Science Awards; Cognition; Communities; Core Facility; Data; Development; Disease; Elderly; Elements; Environment; Epidemiology; Faculty; Funding; Future; Geriatrics; Geroscience; Goals; Grant; Health; Health Professional; Health Promotion; Home environment; Human; Impairment; Inflammation; Inflammatory; Infrastructure; Injury; Institute of Medicine (U.S.); Institutes; Knowledge; Laboratories; Leadership; Link; Longevity; Mediator of activation protein; Medicine; Mentorship; Metabolic; Metabolic Diseases; Methodology; Methods; Michigan; Modeling; Mus; Outcome; Participant; Physical Function; Physical activity; Pilot Projects; Population; Process; Ptosis; Quality of life; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Rodent; Strategic Planning; Structure; Testing; Training; Training Activity; Training Programs; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Urinary Incontinence; Work; age related; aged; base; career development; clinical care; clinical investigation; cognitive function; cohesion; comorbidity; design; disability; education research; falls; functional independence; functional status; healthspan; human disease; human subject; improved; improved outcome; innovation; insight; interest; investigator training; member; mortality; prevent; programs; ranpirnase; research study; senior faculty

Abstract In this competitive renewal application, the University of Michigan Claude D. Pepper Older Americans Independence Center (UM Pepper Center), established in 1989, seeks to provide scientific leadership and innovation for aging research to address the central hypothesis that targeting metabolic and inflammatory factors as critical mediators of geriatric conditions and outcomes improves physical and cognitive functions of older adults. The overarching goal of the UM Pepper Center is to create, enhance and maintain a cohesive intellectual, technological, and administrative environment to maximize geriatrics research that will promote health and functional independence in older adults. The UM Pepper Center will pursue its objectives in five Aims. Aim 1) To support research that addresses the Center’s focus to improve understanding of how metabolic factors and inflammation determine key health outcomes related to mobility and functional status. Aim 2) To support translational research on the interaction of metabolic factors and inflammation with age-related diseases and comorbidities to improve health outcomes related to mobility and functional status. To achieve the aim, the UM Pepper Center will work closely with other UM programs including the Michigan Institute for Clinical and Health Research (MICHR), the home of the UM’s Clinical and Translational Science Award (CTSA). Aim 3) To provide Resource Cores that support and assist investigator-initiated projects related to the UM Pepper Center’s research focus. Aim 4) Through its Research Education Core (REC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research related to the UM Pepper Center’s research focus. Aim 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM faculty to develop new research projects related to the UM Pepper Center’s research focus. The UM Pepper Center has in place a well-established leadership and administrative structure, a REC, a PESC, and four RCs: the Human Subjects and Assessment Core (HSAC); the Biomechanics Core (BC); the Design, Data and Biostatistics Core (DDBC); and the Core Facility for Aged Rodents (CFAR). The REC features three central elements: 1) a competitive program to select 2 promising UM junior faculty per year to conduct research relevant to the UM Pepper Center’s research and guarantee 50% effort for research career development; 2) a nationally recognized research training program for junior faculty engaged in such research, and 3) a Mentorship Program that enhances opportunities for junior faculty members to work closely with one or more UM senior investigators. The PESC will fund 5 or more pilot projects per year by leveraging OAIC funding with multiple other UM institutional resources. The RC’s will support multiple externally funded projects, the Pepper Center pilot grants and REC junior faculty, and continue to develop and test new methods to be used in Pepper Center research.

抽象的 在这份竞争性续签申请中，密歇根大学 Claude D. Pepper 老年美国人 独立中心（UM Pepper 中心）成立于 1989 年，旨在提供科学领导和 衰老研究的创新，旨在解决针对代谢和炎症的中心假设 作为老年疾病和结果的关键调节因素的因素可改善老年人的身体和认知功能 老年人。 UM Pepper 中心的总体目标是创建、增强和维持一个有凝聚力的知识分子、 最大限度地开展老年医学研究的技术和管理环境，从而促进健康和 老年人的功能独立。密歇根大学胡椒中心将实现五个目标。目标1) 支持研究中心的重点是提高对代谢因素和 炎症决定与活动能力和功能状态相关的关键健康结果。目标 2) 支持 代谢因素和炎症与年龄相关疾病相互作用的转化研究 合并症，以改善与活动能力和功能状态相关的健康结果。为了实现这一目标，澳大 胡椒中心将与其他密歇根大学项目密切合作，包括密歇根临床与健康研究所 研究 (MICHR) 是密歇根大学临床和转化科学奖 (CTSA) 的发源地。目标 3) 至 提供资源核心，支持和协助研究者发起的与 UM Pepper 相关的项目 中心的研究重点。目标 4) 通过其研究教育核心 (REC)，加强 UM 培养未来老年病学和老龄化领域的学术领导者的环境，他们可以进行与老年病学和老龄化相关的研究 UM Pepper 中心的研究重点。目标 5) 通过其试点和探索性研究核心 (PESC)， 吸引 UM 教师开发与 UM Pepper 中心研究重点相关的新研究项目。 UM Pepper 中心拥有完善的领导和行政结构、REC、 PESC 和四个 RC：人类受试者和评估核心 (HSAC)；生物力学核心（BC）；这 设计、数据和生物统计核心（DDBC）；和老年啮齿动物核心设施（CFAR）。 REC 具有三个核心要素：1）每年选拔 2 名有前途的 UM 初级教师的竞争性计划 开展与 UM Pepper 中心研究相关的研究，并保证 50% 的努力用于研究事业 发展; 2）国家认可的针对从事此类研究的初级教师的研究培训计划， 3) 导师计划，增加初级教员与一位导师密切合作的机会 或更多 UM 高级研究员。 PESC 将利用 OAIC 每年资助 5 个或更多试点项目 与多个其他 UM 机构资源一起提供资金。 RC 将支持多个外部资助的项目， 胡椒中心试点补助金和 REC 初级教师，并继续开发和测试新方法 用于胡椒中心的研究。