Trans-generational Effects of Social Learning?

社会学习的跨代效应？

• 批准号: 9313942
• 负责人: GIOVANNI BOSCO
• 金额: $ 75.25万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9313942
• 关键词: Address; Animal Behavior; Animals; Cells; Cognitive; Cohort Effect; DNA; Environment; Epigenetic Process; Future Generations; Generations; Individual; Inherited; Lead; Learning; Molecular Genetics; Physiological; Physiology; Process; Social Interaction; benefit sharing; experience; genetic information; learned behavior; public health relevance; social; social learning

 DESCRIPTION (provided by applicant): It is well accepted that cognitive experiences can have physiological consequences, and this has been shown in a variety of animal species. In social animals, groups of individuals share information about the environment and about themselves. This sharing of information is beneficial to those capable of learning from the experiences of others. Social learning can be a highly advantageous adaptive strategy since it allows individuals to anticipate changes in the environment without having direct prior experience of that change. Although it is clear that social experiences can lead to physiological changes, how long-term physiological effects of social learning persist in individuals is not understood. Interestingly, because the physiological consequences of social interactions can be long-lasting it raises the exciting possibility that socially learned behaviors could result in tras-generational effects. How or even if social experiences epigenetically reprogram germline cells in order to transmit information to subsequent generation is completely unexplored territory. This proposal seeks to elucidate molecular genetic mechanisms of how physiological changes are triggered by social learning and how these physiological changes can be inherited by future generations.

 描述（由适用提供）：认知经历可以带来身体后果，并且在各种动物物种中都表明了这一点。在社交动物中，一群人共享有关环境及其自己的信息。信息共享对能够从他人的经验中学习的人有益。社会学习可能是一种非常有利的适应性策略，因为它允许个人在没有直接事先经验的情况下预测环境的变化。尽管很明显，社会经历可以导致身体变化，但社会学习对个人的长期物理影响如何不理解。有趣的是，由于社会互动的生理后果可能是长期的，因此可以使社会学的行为可能导致tras代赋予效应。社会经历如何表观遗传重新编程的生殖细胞以将信息传输到随后的一代是完全出乎意料的领域。该建议旨在阐明分子遗传机制，即社会学习如何触发生理变化以及如何通过后代继承这些物理变化。