Expansion of the MAPP Research Network: Microbial and Biopsychosocial Contributio

MAPP 研究网络的扩展：微生物和生物心理社会贡献

• 批准号: 9113610
• 负责人: JOHN CURTIS NICKEL
• 金额: $ 23.34万
• 依托单位: QUEEN'S UNIVERSITY AT KINGSTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9113610
• 关键词: Address; Bacteria; Biological Markers; Bladder; Chronic Prostatitis; Clinical; Computers; Coping Skills; Cystoscopy; DNA Sequence; Development; Diagnostic; Diet; Disease; Enrollment; Ensure; Environment; Epidemiology; Etiology; Exercise; Flare; Funding; Health; Healthcare Systems; Infection; Inflammatory; Interstitial Cystitis; Life; Location; Lower urinary tract; Mental Depression; Methods; Molecular; Monitor; Nickel; Outcome; Pain; Pain Map; Pain quality; Pathogenicity; Patients; Pattern; Pelvic Pain; Pelvic floor structure; Phenotype; Principal Investigator; Psychosocial Assessment and Care; Quality of life; Research; Severities; Site; Sleep; Societies; Specific qualifier value; Stress; Symptoms; Technology; Time; United States National Institutes of Health; Work; base; biopsychosocial; chronic pain; chronic pelvic pain; clinical phenotype; experience; fungus; illness perceptions; individual patient; microbial; microbiome; microbiota; next generation; novel; patient population; patient subsets; population based; predictive tools; programs; protocol development; psychologic; social; success; urinary; urologic

DESCRIPTION (provided by applicant): Dr. Nickel and his collaborative research network have undertaken numerous etiology, epidemiology, diagnostic, and treatment studies in the field of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and interstitial cystitis/bladder pain syndrome (IC/BPS) referred to collectively as Urologic Chronic Pelvic Pain Syndrome (UCPPS). He and his research group have participated in the NIH funded CPCRN (1 and 2), ICTTG and ICCRN collaborative research networks evaluating CP/CPPS and IC/BPS respectively and Dr. Nickel was the Project Leader for the first Trans-MAPP Infection Etiology Study. Based on this experience, we hypothesize that symptom severity, impact and patterns (including flares) in defined patient phenotypes are associated with very heterogeneous patient-specific urinary microbial or microbiome patterns (or changes) as well as (partner) factors, other psychological parameters (depression, catastrophizing, illness perception), sleep, sexual status, and environment factors (diet, perceived stress, exercise). Our aim (Aim 1) is the enhance the proposed trans-MAPP Symptom Pattern Study by becoming an active Discovery Site, employing our expertise and experience to assist in patient enrollment (particularly difficult to enroll patient subtypes) as well as to suggest clinical, physical, urological and psychosocial assessment and outcome tools for predictive phenotype identification. We further plan (Aim 2) to expand our initial and ongoing trans-MAPP Infection Etiology Project (using state of the art culture independent technology) to determine the clinical implications and impact of the microbiome of the lower urinary tract on symptoms (symptom phenotype) and changing symptom patterns (including flares) in patients with UCPPS enrolled in the trans-MAPP Symptom Pattern Study.

描述(申请人提供)：Nickel博士和他的合作研究网络在慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)和间质性膀胱炎/膀胱疼痛综合征(IC/BPS)领域进行了大量的病因学、流行病学、诊断和治疗研究，统称为泌尿系慢性盆腔疼痛综合征(UCPPS)。他和他的研究小组参与了NIH资助的CPCRN(1和2)、ICTTG和ICCRN合作研究网络，分别评估CP/CPPS和IC/BPS，Nickel博士是第一项跨Mapp感染病因学研究的项目负责人。根据这一经验，我们假设，确定的患者表型中的症状严重性、影响和模式(包括闪光)与非常不同的患者特定的尿液微生物或微生物组模式(或变化)以及(伴侣)因素、其他心理参数(抑郁、灾难、疾病感知)、睡眠、性状态和环境因素(饮食、感知压力、锻炼)有关。我们的目标(目标1)是加强拟议的跨MAPP症状模式研究，成为一个积极的发现网站，利用我们的专业知识和经验来帮助患者登记(特别是难以登记的患者亚型)，以及建议用于预测表型鉴定的临床、生理、泌尿和心理社会评估和结果工具。我们进一步计划(目标2)扩大我们最初和正在进行的跨MAPP感染病因学项目(使用最先进的培养独立技术)，以确定下尿路微生物群对参加跨MAPP症状模式研究的UCPPS患者的症状(症状表型)和变化的症状模式(包括红斑)的临床意义和影响。