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Integrative Center for Neurogenetics and Neurogenomics - Overall

神经遗传学和神经基因组学综合中心 - 总体

基本信息

批准号：
9131813
负责人：
Giovanni Coppola
金额：
$ 61.6万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9131813
关键词：
Affect Agreement Amyotrophic Lateral Sclerosis Animal Model Applications Grants Autistic Disorder Award Bioinformatics Brain Brain Diseases Budgets Cell model Collaborations Communities Computational Biology Computer Analysis Computer software Consultations Data Data Analyses Databases Development Disease Ensure Experimental Designs Faculty Fostering Foundations Frontotemporal Dementia Funding Gap Junctions Genetic Genome Genomic approach Genomics Gilles de la Tourette syndrome Grant High Performance Computing Human Human Genome Individual Informatics International Investigation Laboratories Large-Scale Sequencing Leadership Letters Mammals Mentors Methods Morus Names National Institute of Neurological Disorders and Stroke Nervous system structure Neurosciences Neurosciences Research Patients Play Publications Qualifying Quantitative Trait Loci Reporting Research Research Infrastructure Research Personnel Resource Sharing Resources Role Sales Science Scientist Services Site Solid Specific qualifier value Speed Tissues Training Training Activity Untranslated RNA Variant Wages computer infrastructure computerized tools computing resources cost genome sequencing genomic data innovation member method development neurogenetics neuropsychiatric disorder novel programs public health relevance ranpirnase relating to nervous system training project user-friendly whole genome

项目摘要

DESCRIPTION (provided by applicant): This application is to renew an NINDS P30 Institutional Center Core, the NINDS Informatics Center for Neurogenetics and Neurogenomics, ICNN. The ICNN, founded in 2009, facilitates research in genetics and genomics for members of the large and highly interactive neuroscience community at UCLA. Over the past funding cycle, ICNN has 1) accelerated the progress of ten projects from eight NINDS-funded investigators specified in the initial application; 2) through an ARRA supplement and a sales and service agreement, extended its scope and support to additional neuroscientists at UCLA, so that is it is now involved in one third of all the NINDS R01s awarded to UCLA neuroscientists, essentially all the ones encompassing genomic studies; 3) contributed to 29 publications (+8 submitted), and multiple successful grant applications, including mentoring on training awards; and 4) expanded its faculty and analysis portfolio, to emphasize collaborations between leaders in computational biology and neurogenetics, and the implementation of innovative methods for data analysis. In summary, ICNN, in its initial award period, laid the foundation for a long-term, self- sustained entity supporting genomics neuroscience research at UCLA and has facilitated a number of projects and training grants. With an expanded faculty and a solid computational infrastructure put in place in the previous funding cycle, ICNN proposes in the renewal to continue to support NINDS grants (15 from 9 named users), to continue to develop innovative genetics and genomics approaches, and to continue to foster neurogenetics and neurogenomics for the neuroscience community at UCLA.

描述（由申请人提供）：本申请旨在更新 NINDS P30 机构中心核心，即 NINDS 神经遗传学和神经基因组学信息学中心 (ICNN)。 ICNN 成立于 2009 年，旨在促进加州大学洛杉矶分校大型且高度互动的神经科学界成员的遗传学和基因组学研究。在过去的资助周期中，ICNN 1) 加速了最初申请中指定的 8 名 NINDS 资助研究人员的 10 个项目的进展； 2) 通过 ARRA 补充以及销售和服务协议，将其范围和支持扩展到加州大学洛杉矶分校的其他神经科学家，因此它现在参与了授予加州大学洛杉矶分校神经科学家的所有 NINDS R01 的三分之一，基本上所有涉及基因组研究的项目； 3) 撰写了 29 篇出版物（+8 篇已提交），并成功完成多项资助申请，包括培训奖项的指导； 4) 扩大其师资和分析组合，强调计算生物学和神经遗传学领域领导者之间的合作，以及数据分析创新方法的实施。总之，ICNN 在其最初的获奖期间为支持加州大学洛杉矶分校的基因组神经科学研究奠定了长期、自我维持的实体的基础，并促进了许多项目和培训资助。随着上一个资助周期扩大的师资队伍和坚实的计算基础设施到位，ICNN 在续约中提议继续支持 NINDS 拨款（9 个指定用户中的 15 项），继续开发创新的遗传学和基因组学方法，并继续为加州大学洛杉矶分校的神经科学界培育神经遗传学和神经基因组学。