Core C: Data Coordinating Core

核心C：数据协调核心

• 批准号: 9292164
• 负责人: Giovanni Coppola
• 金额: $ 18.27万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9292164
• 关键词: Algorithms; Area; Cell model; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Collection; Communication; Communities; Data; Data Analyses; Data Set; Databases; Ensure; Gene Expression; Generations; Genomics; Goals; Government; Knowledge; Link; Literature; Methods; Mission; Nerve Degeneration; Network-based; Neurons; Online Systems; Patients; Play; Proteomics; Public Domains; Research; Research Infrastructure; Research Personnel; Resources; Series; Tauopathies; data format; data sharing; data visualization; differential expression; meetings; phenotypic data; research study; tau Proteins; tool; transcriptomics

SUMMARY The mission of the Data Core is to accelerate the Center's communication, progress, and sharing. The Core activities towards these goals will be distributed across three main areas, corresponding to the three Specific Aims: 1) to facilitate communication, collaboration, and sharing within the Center, by establishing an infrastructure for data sharing, quality and integrity checks, and storage; 2) to analyze data in collaboration with Center Investigators, and other Cores, by using a series of algorithms for data analysis, ranging from standard differential expression analysis to advanced, network-based methods for integration of multidimensional datasets; 3) to share high-throughput data generated by the center with the research community through the use of government and nongovernment-sponsored public databases. By interacting with all Projects and Cores, the Data Core will provide a key infrastructure for data analysis and intra-Center communication. By contributing to public repositories data generated in valuable cellular models of tauopathy – and from patients with neurodegeneration – in Projects and Cores, the Data Core will play a key role in disseminating the knowledge generated by the entire Center.

总结 数据核心的使命是加速中心的沟通、进步和共享。核心 为实现这些目标而开展的活动将分布在三个主要领域， 目的：1）促进中心内部的沟通，协作和共享，通过建立一个 用于数据共享、质量和完整性检查以及存储的基础设施; 2）与 中心研究员和其他核心，通过使用一系列算法进行数据分析，从标准 差异表达分析，以先进的，基于网络的多维整合方法 数据集; 3）通过与研究界共享中心生成的高通量数据， 使用政府和非政府组织赞助的公共数据库。通过与所有项目的互动， 数据核心将为数据分析和中心内部通信提供关键基础设施。通过 为公共数据库提供有价值的tau蛋白病细胞模型中产生的数据-以及来自患者的数据 在项目和核心中，数据核心将在传播 整个中心的知识。