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Integrative Center for Neurogenetics and Neurogenomics - Overall

神经遗传学和神经基因组学综合中心 - 总体

基本信息

批准号：
9332490
负责人：
Giovanni Coppola
金额：
$ 61.6万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2019-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9332490
关键词：
Affect Agreement Amyotrophic Lateral Sclerosis Animal Model Applications Grants Autistic Disorder Award Bioinformatics Brain Brain Diseases Budgets Cell model Collaborations Communities Computational Biology Computer software Consultations Data Data Analyses Databases Development Disease Ensure Experimental Designs Faculty Fostering Foundations Frontotemporal Dementia Funding Gap Junctions Genetic Genome Genomic approach Genomics Gilles de la Tourette syndrome Grant High Performance Computing Human Human Genome Individual Informatics International Investigation Laboratories Large-Scale Sequencing Leadership Letters Mammals Mentors Methods Names National Institute of Neurological Disorders and Stroke Nervous system structure Neurosciences Neurosciences Research Patients Phenotype Play Publications Qualifying Quantitative Trait Loci Reporting Research Research Infrastructure Research Personnel Resource Sharing Resources Role Sales Science Scientist Services Site Solid Specific qualifier value Speed Statistical Data Interpretation Tissues Training Training Activity Untranslated RNA Variant Wages computer infrastructure computerized tools computing resources cost genetic approach genome sequencing genomic data innovation member method development neurogenetics neuropsychiatric disorder novel programs public health relevance ranpirnase relating to nervous system user-friendly whole genome

项目摘要

DESCRIPTION (provided by applicant): This application is to renew an NINDS P30 Institutional Center Core, the NINDS Informatics Center for Neurogenetics and Neurogenomics, ICNN. The ICNN, founded in 2009, facilitates research in genetics and genomics for members of the large and highly interactive neuroscience community at UCLA. Over the past funding cycle, ICNN has 1) accelerated the progress of ten projects from eight NINDS-funded investigators specified in the initial application; 2) through an ARRA supplement and a sales and service agreement, extended its scope and support to additional neuroscientists at UCLA, so that is it is now involved in one third of all the NINDS R01s awarded to UCLA neuroscientists, essentially all the ones encompassing genomic studies; 3) contributed to 29 publications (+8 submitted), and multiple successful grant applications, including mentoring on training awards; and 4) expanded its faculty and analysis portfolio, to emphasize collaborations between leaders in computational biology and neurogenetics, and the implementation of innovative methods for data analysis. In summary, ICNN, in its initial award period, laid the foundation for a long-term, self- sustained entity supporting genomics neuroscience research at UCLA and has facilitated a number of projects and training grants. With an expanded faculty and a solid computational infrastructure put in place in the previous funding cycle, ICNN proposes in the renewal to continue to support NINDS grants (15 from 9 named users), to continue to develop innovative genetics and genomics approaches, and to continue to foster neurogenetics and neurogenomics for the neuroscience community at UCLA.

描述(由申请人提供)：此申请是续签NINDS P30机构中心核心，NINDS神经遗传学和神经基因组信息学中心，ICNN。ICNN成立于2009年，为加州大学洛杉矶分校大型且高度互动的神经科学社区的成员提供遗传学和基因组学方面的研究。在过去的资金周期中，ICNN 1)加快了最初申请中指定的8个NINDS资助研究人员的10个项目的进展；2)通过ARRA附录和销售和服务协议，将其范围和支持扩大到加州大学洛杉矶分校的更多神经科学家，因此，它现在参与了授予加州大学洛杉矶分校神经科学家的所有NINDS R01奖的三分之一，基本上所有涉及基因组研究的论文；3)为29篇出版物(+8份提交)做出了贡献，并成功提出了多项拨款申请，包括培训奖的指导；以及4)扩大其教员和分析组合，以强调计算生物学和神经遗传学领域的领导者之间的合作，以及数据分析创新方法的实施。总之，ICNN在最初的授权期内，为支持加州大学洛杉矶分校的基因组神经科学研究的长期、自给自足的实体奠定了基础，并为一些项目和培训赠款提供了便利。在前一个资助周期中，ICNN扩大了教师队伍并建立了坚实的计算基础设施，ICNN在更新中建议继续支持NINDS赠款(来自9个指定用户的15个)，继续开发创新的遗传学和基因组学方法，并继续为加州大学洛杉矶分校的神经科学界促进神经遗传学和神经基因组学。