The Negative BOLD Response in Speech Production and Persistent Stuttering

言语产生和持续口吃中的消极大胆反应

基本信息

批准号：
9227237
负责人：
Vincent L. Gracco
金额：
$ 19.65万
依托单位：
HASKINS LABORATORIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9227237
关键词：
Address Adult Affect Area Basal Ganglia Behavior Behavioral Behavioral Symptoms Biological Markers Biological Neural Networks Brain Brain region Characteristics Child Chronic Cognitive Computer Simulation Data Development Disease Equilibrium Foxes Frequencies Goals Human Individual Language Linguistics Literature Maintenance Modeling Neural Inhibition Neurobiology Neurodevelopmental Disorder Neuronal Plasticity Neurophysiology - biologic function Neurotransmitters Pattern Perception Price Process Production Recruitment Activity Research Severities Signal Transduction Speech Speech Development Speech Disorders Structure Stuttering Suggestion System Testing Theoretical model associated symptom base blood oxygen level dependent blood oxygenation level dependent response brain behavior economic impact improved neuroimaging neuromechanism neurovascular psychosocial relating to nervous system response sensory input theories

项目摘要

Difficulty in producing fluent speech is the core of stuttering, a neurodevelopmental speech disorder affecting children into adulthood with long-term psychosocial and economic impact. A characteristic of the disorder is that even when producing perceptually fluent speech, there are differences in the brain and behavioural processes for individuals who stutter compared to those that do not. Unfortunately, after decades of research involving behavioral description, structural and functional neuroimaging and computational modeling, no coherent neurobiological framework for the disorder exists. The current proposal is a first step toward developing a neural mechanistic model for stuttering with application to other neurodevelopmental disorders of spoken language production. The over-arching hypothesis is that stuttering is associated with a reduced level of neural inhibition, as reflected in a reduction in the negative blood-oxygen-level-dependent (BOLD) signal response (NBR). This reduction in inhibition during development has long-term and wide-ranging effects on brain structure and function and the stability and dynamics of neural networks for speech potentially impacting all or some sensorimotor, linguistic and cognitive behaviours. The empirical data and conceptual framework will impact speech production models and theories by adding a currently missing neural component process to the manner in which speech is produced and pave the way for a more informed and neurobiological model of neurodevelopmental speech disorders.

产生流利的语音的困难是口吃的核心，这是一种神经发育的言语障碍，影响儿童成年，具有长期的社会心理和经济影响。该疾病的一个特征是，即使在感知流利的语音上产生脑部和行为过程的差异，与那些没有的人相比，口吃的个体也存在差异。不幸的是，经过数十年的研究，涉及行为描述，结构和功能性神经影像和计算建模，没有针对该疾病的连贯的神经生物学框架。当前的提案是开发神经机械模型的第一步，用于将语言生产的其他神经发育障碍应用使用。总结的假设是口吃与神经抑制的降低有关，这反映在减少阴性血氧级依赖性（BOLD）信号反应（NBR）的情况下。开发过程中抑制作用的减少对大脑结构和功能以及神经网络的稳定性和动态具有长期和广泛的影响，以影响所有或某些感觉运动，语言和认知行为。经验数据和概念框架将通过将当前缺失的神经成分过程添加到言语的方式中，从而影响语音生产模型和理论，并为神经发育语音障碍的更知情和神经生物学模型铺平道路。