Core F: Biostatistics and Bioinformatics Core

项目摘要：生物统计学和生物信息学核心（核心F） 生物统计学和生物信息学核心的总体目标是确保高质量的统计和数据 管理支持和培训CFAR调查人员在设计，实施，分析， 艾滋病毒/艾滋病相关研究的出版阶段。为了达到这一目的，核心F将提供生物统计学 和生物信息学服务，提供小组和个人培训机会，以及 确保调查人员和生物统计人员之间的联系，他们可以协助制定方法 解决基础、临床、转化和临床领域的非标准研究设计和数据分析挑战， 社会/行为研究通过核心F向CFAR调查人员提供的教育机会将 包括关于艾滋病研究中新兴分析主题的教程、研讨会和专业培训。先进 生物统计服务将包括开发新的分析技术，以加强 艾滋病毒/艾滋病项目依赖于基因组学和代谢组学数据， 疾病和治疗，因果推理，传播动力学的数学建模，以及有效的 病毒学和免疫学分析的评价以及所得数据的利用。核心将提供 支持埃默里CFAR科学工作组（SWG），并保持有效的跨核心 与发展，临床研究，预防科学，免疫学和病毒学合作， 分子生物标志物核心通过建立生物统计学家联络。核心将安全添加 通过促进和加强艾滋病毒/艾滋病研究的科学严谨性， 由CFAR调查员进行。

Project Summary: Biostatistics and Bioinformatics Core (Core F) The overall goal of the Biostatistics and Bioinformatics Core is to ensure high-quality statistical and data management support and training for CFAR investigators in the design, implementation, analysis, and publication stages of HIV/AIDS-related research. In keeping with this purpose, Core F will provide biostatistical and bioinformatics services to investigators, provide access to group and individual training opportunities, and secure linkages between investigators and biostatisticians, who can assist with methodological developments to address non-standard study design and data analytic challenges in basic, clinical, translational, and social/behavioral research. Educational opportunities available to CFAR investigators through Core F will include tutorials, seminars, and specialty training on emerging analytic topics in HIV research. Advanced biostatistics services available will include the development of novel analytic techniques to strengthen HIV/AIDS projects dependent on genomic and metabolomics data, analysis of spatiotemporal patterns of disease and treatment, causal inference, mathematical modeling of transmission dynamics, and the effective evaluation of virologic and immunological assays and utilization of the resulting data. The Core will provide support for the Emory CFAR Scientific Working Groups (SWGs), and maintain effective cross-core collaborations with the Developmental, Clinical Research, Prevention Science, Immunology, and Virology and Molecular Biomarkers Cores through the establishment of liaison biostatisticians. The Core will secure added value to the Emory CFAR as a whole, by enabling and enhancing the scientific rigor of HIV/AIDS research undertaken by CFAR investigators.