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Development and validation of an epigenetic clock in Fischer 344 rats.

Development and validation of an epigenetic clock in Fischer 344 rats.
Fischer 344 大鼠表观遗传时钟的开发和验证。
批准号：
10263717
负责人：
Luigi Ferrucci
金额：
$4.96万
依托单位：
NATIONAL INSTITUTE ON AGING
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10263717
关键词：
AgeAgingAlgorithmsAnimal ModelBehavior assessmentBehavioralBiological ModelsBloodBlood CellsClipComplexDNA MethylationDataDevelopmentEarEpigenetic ProcessFemaleHumanImmunophenotypingInbred Strains RatsLaboratoriesLifeLinkManuscriptsMegapteraMethylationMolecularPathway AnalysisPhenotypePhyseteridaePhysiologicalPublicationsRattusReportingSamplingSignal TransductionTimeTissuesValidationWhole Bloodage relatedbasecognitive functionexperimental studyfollow-upfrailtyindexingmalemortalitynoveltraittranslation to humansunsupervised learning

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英文摘要
The past year has been spent wrapping up the analysis and preparing a publication that is in the latest stages of review at E-Life. In this manuscript we report a novel epigenetic clock in rats integrating behavioral data, unsupervised machine learning, and network analysis to identify epigenetic signals that not only track with age, but also relate to phenotypic aging and reflect higher-order molecular aging changes. Our next steps moving forward with the data produced will aid our ability to unravel the complex signals linking DNA methylation changes to functional aging would require experimental studies in model systems in which longitudinal epigenetic changes can be related to other molecular and physiological hallmarks of aging.
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Temporary CARD Facility
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    10291099
  • 项目类别：
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    $3029.09万
  • 财政年份：
    --
  • 负责人：
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  • 依托单位：
    NATIONAL INSTITUTE ON AGING
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  • 批准号：
    6828820
  • 项目类别：
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    $0.0万
  • 财政年份：
    --
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  • 批准号：
    8335774
  • 项目类别：
  • 资助金额：
    $30.19万
  • 财政年份：
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  • 负责人：
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  • 依托单位：
    NATIONAL INSTITUTE ON AGING
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  • 批准号：
    8335795
  • 项目类别：
  • 资助金额：
    $10.68万
  • 财政年份：
    --
  • 负责人：
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  • 依托单位：
    NATIONAL INSTITUTE ON AGING
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