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Advanced Imaging and Dosimetry Core

先进的成像和剂量测定核心

基本信息

批准号：
10024892
负责人：
Bryan Patrick Bednarz
金额：
$ 29.37万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10024892
关键词：
3-Dimensional Animals Bioinformatics Biometry Calibration Cancer Center Cancer Model Clinical Communities Comprehensive Cancer Center Computational algorithm Computer software Data Deposition Discipline of Nuclear Medicine Dose Drug Kinetics Emission-Computed Tomography Ensure Equipment Experimental Designs Funding Goals Human Image Image Analysis Immunization Immunologics Immunosuppression Immunotherapy Individual Infrastructure Institutes Lead Leadership Magnetic Resonance Malignant Neoplasms Maps Medical Medical Research Modeling Molecular Target National Cancer Institute Normal tissue morphology Patient Selection Patient-Focused Outcomes Patients Pharmaceutical Preparations Physics Positron-Emission Tomography Process Production Protocols documentation Publications Quality Control Radiation therapy Radiochemistry Radioisotopes Radionuclide therapy Radiopharmaceuticals Renaissance Reporting Research Research Personnel Resources Rodent Savings Scanning Services Therapeutic Time Toxic effect Translating Treatment Efficacy Tumor Tissue Uncertainty United States Food and Drug Administration Universities University resources Wisconsin X-Ray Computed Tomography animal imaging base clinical translation companion animal cost efficient dosimetry drug distribution experience imaging facilities immunomodulatory strategy immunoregulation improved individualized medicine next generation operation optical imaging professor quality assurance quantitative imaging response symposium theranostics treatment planning treatment response tumor tumor microenvironment

项目摘要

PROJECT SUMMARY The Advanced Imaging and Dosimetry Core (AIDC) provides the infrastructure, resources, and expertise required to facilitate quantitative multiscale imaging and dosimetry calculations, which are required to optimally synergize the combination of molecular targeted radionuclide therapy (TRT) and immunotherapy (ImmRx). The AIDC is a centralized dosimetry service that will ensure consistent scientific rigor and dosimetry reporting across each of the Projects of this PO1 proposal, entitled “Molecular targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy response”. Furthermore, the significance of centralizing this process for each Project is the tremendous gain in efficiency that are achieved, ultimately saving individual investigators time and effort. Additionally, the AIDC will expand the leadership and operation of the Small Animal Imaging and Radiotherapy Facility (SAIRF) by offering support in all stages of the imaging and TRT dosimetry process, including calibration, experimental design, image acquisition optimization, pharmacokinetic profiling and modeling, micro-and macroscopic 3D dose calculations, and treatment response assessment. The AIDC will emphasize quality assurance and quality control in all aspects of the imaging and dosimetry process so that results are validated for application to the FDA. The AIDC will collaborate closely with the Radionuclide Production and Radiochemistry Core (RPRC) for dose calibration and traceability of the radiopharmaceuticals; and, the AIDC will collaborate with the Biostatistics and Bioinformatics Core (BBC) to help interpret imaging and dosimetry findings to validate response assessment. Lastly, the AIDC will help investigators disseminate their findings to the scientific community through publications and conference presentations. Renowned experts in the field of TRT dosimetry, Professor Bryan Bednarz and Joseph Grudzinski, will lead administrative and technical efforts, respectively.

项目总结