Advanced Imaging and Dosimetry Core

项目总结 高级成像和剂量测量核心(AIDC)提供基础设施、资源和专业知识 促进定量多尺度成像和剂量计算所需的，这是以最佳方式 分子靶向放射性核素疗法(TRT)和免疫疗法(ImmRx)的协同作用。这个 AIDC是一项集中式剂量测定服务，将确保在以下方面提供一致的科学严谨性和剂量测定报告 该PO1提案的每一个项目，题为《肿瘤的分子靶向放射性核素治疗》 免疫调节和增强免疫治疗反应“。此外，集中这一点的意义 每个项目的过程都是在效率上获得的巨大收益，最终节省了个人 调查人员的时间和精力。此外，AIDC还将扩大对小动物的领导和运营 成像和放射治疗设施(SAIRF)，通过在成像和TRT剂量测量的所有阶段提供支持 过程，包括校准、实验设计、图像采集优化、药动学分析 以及建模、微观和宏观3D剂量计算以及治疗反应评估。这个 AIDC将在成像和剂量测定过程的所有方面强调质量保证和质量控制 以便验证结果是否适用于FDA。AIDC将与放射性核素密切合作 生产和放射化学核心(RPRC)，用于放射性药物的剂量校准和可追溯性； AIDC将与生物统计和生物信息学核心(BBC)合作，帮助解释成像和 用于验证响应评估的剂量学结果。最后，AIDC将帮助调查人员传播他们的 通过出版物和会议报告向科学界介绍研究成果。著名专家在 TRT剂量学领域的Bryan Bednarz教授和Joseph Grudzinski将领导行政和 分别是技术上的努力。

PROJECT SUMMARY The Advanced Imaging and Dosimetry Core (AIDC) provides the infrastructure, resources, and expertise required to facilitate quantitative multiscale imaging and dosimetry calculations, which are required to optimally synergize the combination of molecular targeted radionuclide therapy (TRT) and immunotherapy (ImmRx). The AIDC is a centralized dosimetry service that will ensure consistent scientific rigor and dosimetry reporting across each of the Projects of this PO1 proposal, entitled “Molecular targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy response”. Furthermore, the significance of centralizing this process for each Project is the tremendous gain in efficiency that are achieved, ultimately saving individual investigators time and effort. Additionally, the AIDC will expand the leadership and operation of the Small Animal Imaging and Radiotherapy Facility (SAIRF) by offering support in all stages of the imaging and TRT dosimetry process, including calibration, experimental design, image acquisition optimization, pharmacokinetic profiling and modeling, micro-and macroscopic 3D dose calculations, and treatment response assessment. The AIDC will emphasize quality assurance and quality control in all aspects of the imaging and dosimetry process so that results are validated for application to the FDA. The AIDC will collaborate closely with the Radionuclide Production and Radiochemistry Core (RPRC) for dose calibration and traceability of the radiopharmaceuticals; and, the AIDC will collaborate with the Biostatistics and Bioinformatics Core (BBC) to help interpret imaging and dosimetry findings to validate response assessment. Lastly, the AIDC will help investigators disseminate their findings to the scientific community through publications and conference presentations. Renowned experts in the field of TRT dosimetry, Professor Bryan Bednarz and Joseph Grudzinski, will lead administrative and technical efforts, respectively.