Advanced Imaging and Dosimetry Core

先进的成像和剂量测定核心

• 批准号: 10263252
• 负责人: Bryan Patrick Bednarz
• 金额: $ 29.45万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263252
• 关键词: 3-Dimensional; Animals; Bioinformatics; Biometry; Calibration; Cancer Center; Cancer Model; Clinical; Communities; Comprehensive Cancer Center; Computational algorithm; Computer software; Data; Deposition; Discipline of Nuclear Medicine; Dose; Drug Kinetics; Emission-Computed Tomography; Ensure; Equipment; Experimental Designs; Funding; Goals; Human; Image; Image Analysis; Immunization; Immunologics; Immunosuppression; Immunotherapy; Individual; Infrastructure; Institutes; Lead; Leadership; Magnetic Resonance; Malignant Neoplasms; Maps; Medical; Medical Research; Modeling; Molecular Target; National Cancer Institute; Normal tissue morphology; Patient Selection; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Physics; Positron-Emission Tomography; Process; Production; Protocols documentation; Publications; Quality Control; Radiation therapy; Radiochemistry; Radioisotopes; Radionuclide therapy; Radiopharmaceuticals; Renaissance; Reporting; Research; Research Personnel; Resources; Rodent; Savings; Scanning; Services; Therapeutic; Time; Toxic effect; Translating; Treatment Efficacy; Tumor Tissue; Uncertainty; United States Food and Drug Administration; Universities; University resources; Wisconsin; X-Ray Computed Tomography; animal imaging; base; clinical translation; companion animal; cost efficient; dosimetry; drug distribution; experience; imaging facilities; immunomodulatory strategy; immunoregulation; improved; individualized medicine; next generation; operation; optical imaging; professor; quality assurance; quantitative imaging; response; symposium; theranostics; treatment planning; treatment response; tumor; tumor microenvironment

PROJECT SUMMARY The Advanced Imaging and Dosimetry Core (AIDC) provides the infrastructure, resources, and expertise required to facilitate quantitative multiscale imaging and dosimetry calculations, which are required to optimally synergize the combination of molecular targeted radionuclide therapy (TRT) and immunotherapy (ImmRx). The AIDC is a centralized dosimetry service that will ensure consistent scientific rigor and dosimetry reporting across each of the Projects of this PO1 proposal, entitled “Molecular targeted radionuclide therapy for tumor immunomodulation and enhancing immunotherapy response”. Furthermore, the significance of centralizing this process for each Project is the tremendous gain in efficiency that are achieved, ultimately saving individual investigators time and effort. Additionally, the AIDC will expand the leadership and operation of the Small Animal Imaging and Radiotherapy Facility (SAIRF) by offering support in all stages of the imaging and TRT dosimetry process, including calibration, experimental design, image acquisition optimization, pharmacokinetic profiling and modeling, micro-and macroscopic 3D dose calculations, and treatment response assessment. The AIDC will emphasize quality assurance and quality control in all aspects of the imaging and dosimetry process so that results are validated for application to the FDA. The AIDC will collaborate closely with the Radionuclide Production and Radiochemistry Core (RPRC) for dose calibration and traceability of the radiopharmaceuticals; and, the AIDC will collaborate with the Biostatistics and Bioinformatics Core (BBC) to help interpret imaging and dosimetry findings to validate response assessment. Lastly, the AIDC will help investigators disseminate their findings to the scientific community through publications and conference presentations. Renowned experts in the field of TRT dosimetry, Professor Bryan Bednarz and Joseph Grudzinski, will lead administrative and technical efforts, respectively.

项目摘要 高级成像和剂量测定核心（AIDC）提供基础设施、资源和专业知识， 需要促进定量多尺度成像和剂量测定计算，这需要最佳地 协同分子靶向放射性核素治疗（TRT）和免疫治疗（ImmRx）的组合。的 AIDC是一个集中的剂量测定服务，将确保一致的科学严谨性和剂量测定报告， 本PO 1提案中的每个项目，题为“肿瘤的分子靶向放射性核素治疗”， 免疫调节和增强免疫治疗反应”。此外，集中这一点的重要性 每个项目的流程都是实现效率的巨大收益，最终节省个人 调查人员的时间和精力。此外，AIDC将扩大小动物的领导和运营 成像和放射治疗机构（SAIRF），在成像和TRT剂量测定的所有阶段提供支持 过程，包括校准、实验设计、图像采集优化、药代动力学分析 和建模、微观和宏观3D剂量计算以及治疗反应评估。的 AIDC将强调成像和剂量测定过程所有方面的质量保证和质量控制 这样结果就能通过FDA的验证AIDC将与放射性核素 生产和放射化学核心（RPRC），用于放射性药物的剂量校准和溯源; 此外，AIDC将与生物统计学和生物信息学核心（BBC）合作，帮助解释成像， 剂量测定结果，以确认反应评估。最后，AIDC将帮助调查人员传播他们的 通过出版物和会议报告向科学界介绍研究结果。知名专家 TRT剂量学领域的Bryan Bednarz教授和Joseph Grudzinski教授将领导行政和 技术方面的努力。