Administrative Coordinating Center: Cardiovascular Development and Pediatric Cardiac Genomics Consortia

行政协调中心：心血管发育和儿科心脏基因组学联盟

• 批准号: 9198577
• 负责人: Eileen Catherine King
• 金额: $ 650.5万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9198577
• 关键词: Basic Science; Cardiovascular Diseases; Cardiovascular system; Child; Childhood; Clinical; Clinical Research; Collaborations; Communities; Congenital Heart Defects; Data; Development; Epidemiology; Genetic; Heart; Heart Diseases; Human; Infant; Informatics; Knowledge; Molecular; National Heart, Lung, and Blood Institute; Neurocognitive; Outcome; Pathway interactions; Patients; Pediatric Cardiac Genomics Consortium; Process; Reproducibility of Results; Research; Research Infrastructure; Resources; Technology; Testing; Translating; Translational Research; clinical care; congenital heart disorder; data integration; data management; data sharing; experience; genetic variant; infant death; operation; patient population; programs; public health relevance; research clinical testing; statistics; young adult

 DESCRIPTION (provided by applicant): Congenital heart defects occur in approximately 40,000 infants in the US each year and are a major cause of infant death. The Bench to Bassinet Program (B2B) was launched by the National Heart, Lung, and Blood Institute (NHLBI) to accelerate pediatric cardiovascular translational research from discovery to early translational testing to clinical testing. Components of the B2B program include the Cardiovascular Development Consortium (CvDC), Pediatric Cardiac Genomics Consortium (PCGC). The objectives of the CvDC are to generate and disseminate comprehensive data about molecular networks and pathways that regulate cardiovascular development. Objectives of the PCGC are to identify genetic causes of human congenital heart disease and to relate genetic variants present in the congenital heart disease patient population to clinical outcomes. The consortia interact with each other, and with the NHLBI Pediatric Heart Network (PHN) to efficiently translate results from basic science to clinical research, and to provide clinical input on pressin needs for basic research. The Administrative Coordinating Center (ACC) provides the infrastructure to enhance collaborations among the consortia and to identify and facilitate the translational research process for the most important pediatric cardiovascular clinical care problems. The ACC will drive standards that are required for data integration and sharing, leading to reproducibility of results. Our proposed ACC to support the CvDC and PCGC is a unique, integrated combination of world-leading pediatric cardiovascular and neurocognitive clinical/translational research expertise, advanced infrastructure, outstanding institutional support, and state-of-the-art technology. We believe these strengths to be critical for an ACC to successfully partner with the B2B program and NHLBI in leading the coordination of knowledge and data for this important pediatric cardiovascular research effort. Synopsis Research for patients with congenital heart disease requires a cooperative and coordinated effort among research programs to efficiently translate results from basic science to clinical research, and to provide clinical input on pressing needs for basic research. Our proposed ACC to support the CvDC and PCGC is a unique, integrated combination of world-leading pediatric cardiovascular and neurocognitive clinical/translational research expertise, advanced infrastructure, outstanding institutional support, and state-of-the-art technology.

 描述（申请人提供）：美国每年约有40，000名婴儿发生先天性心脏缺陷，是婴儿死亡的主要原因。由国家心肺血液研究所（NHLBI）发起的“从实验室到摇篮”计划（B2B）旨在加速儿科心血管转化研究从发现到早期转化 测试到临床测试。B2B计划的组成部分包括心血管发展联盟（CvDC），儿科心脏基因组学联盟（PCGC）。CvDC的目标是生成和传播有关调节心血管发育的分子网络和途径的综合数据。PCGC的目的是确定人类先天性心脏病的遗传原因，并将先天性心脏病患者人群中存在的遗传变异与临床结局联系起来。这些联盟彼此互动，并与NHLBI儿科心脏网络（PHN）进行互动，以有效地将基础科学的结果转化为临床研究，并为基础研究的紧迫需求提供临床投入。行政协调中心（ACC）提供基础设施，以加强联盟之间的合作，并确定和促进最重要的儿科心血管临床护理问题的转化研究过程。ACC将推动数据集成和共享所需的标准，从而实现结果的可重复性。我们建议的ACC支持CvDC和PCGC是世界领先的儿科心血管和神经认知临床/转化研究专业知识，先进的基础设施，出色的机构支持和最先进的技术的独特综合组合。我们相信，这些优势对于ACC成功与B2B项目和NHLBI合作，领导这一重要儿科心血管研究工作的知识和数据协调至关重要。先天性心脏病患者的研究需要研究计划之间的合作和协调努力，以有效地将基础科学的结果转化为临床研究，并为基础研究的迫切需求提供临床投入。我们建议的ACC支持CvDC和PCGC是世界领先的儿科心血管和神经认知临床/转化研究专业知识，先进的基础设施，出色的机构支持和最先进的技术的独特综合组合。