Research Training in Pediatric Nephrology

描述（由申请人提供）：本申请旨在获得NIH资助，以培训匹兹堡大学/匹兹堡儿童医院（CHP）的儿科肾病研究员，使其成为成功的临床科学家。目前，只有不到5%的美国儿科肾脏病学会会员拥有有效的R 01赠款，很少有部门拥有超过一名或两名NIH资助的儿科肾脏病学家。此外，有几个专门的儿科肾脏病T32培训补助金的位置，可用于培训研究员。鉴于目前的财政困难，医学院和儿科系也很难投入资源培训研究员进行研究。总的来说，通常没有足够的资源和导师来培训儿科肾病学家进行基础，转化或临床研究。由此导致的儿科肾病研究员的缺乏，发展成功的职业生涯在研究中显着阻碍了破译病理生理学的进展，并最终治疗影响儿童的肾脏疾病。该计划的目标是培养儿科肾脏病学研究员成为临床研究人员。将有四个职位，两个为pgy 5和两个为pgy 6儿科肾病医学研究员。研究员将在他们的pgy 4年和项目主任和执行委员会的指导下选择，他们将选择一个研究导师，并召开一个指导委员会。研究员将在他们的PGY 5和6年参加该计划。该培训计划的独特之处在于，该部门有四名（即将成为五名）NIH资助的儿科肾病教师（其中三名有资格成为培训师）。这也是全国最大的儿科肾脏病部门之一，有七个（很快将有八个教师），有一个强大的临床计划，这将提高同行的招聘。除了我们匹兹堡大学的部门之外，还有大量高质量的NIH资助的肾脏/尿路研究，包括医学院和公共卫生学院的研究人员。此外，匹兹堡大学在国家糖尿病、消化和肾脏疾病研究所（NIDDK）获得的NIH奖项中排名第五，其中大部分是肾脏和尿路疾病领域。该计划中的所有教师培训师也有指导博士前和博士后学员的重要记录。研究领域非常多样化，包括专注于基础，转化和临床研究的培训师。环境也非常支持，包括课程，甚至为研究员可选学位（例如生物医学科学基础课程的基础科学和临床研究证书，临床研究硕士或临床/转化科学的公共卫生硕士）。培训计划还非常注重增加受训人员的多样性和关于负责任地开展研究的教育。总之，广泛的研究机会，培训记录和优秀的环境使该机构成为培训研究型儿科肾病研究员的绝佳场所。 公共卫生相关性：儿科肾脏病学描述了治疗肾脏疾病儿童的医学领域。很少有儿科肾病学家接受过儿童肾脏疾病原因的研究培训;因此，这降低了快速找到儿童肾脏疾病治愈方法的机会。该项目的目的是培养更多的儿科肾脏病医生对儿童肾脏疾病的原因进行研究。

DESCRIPTION (provided by applicant): This application seeks to obtain NIH funding to train pediatric nephrology fellows at the University of Pittsburgh/Children's Hospital of Pittsburgh (CHP) to become successful clinician scientists. Presently fewer than 5% of the membership of the American Society of Pediatric Nephrology have active R01 grants and few Divisions have more than one or two NIH funded Pediatric Nephrologists. Furthermore, there are few dedicated pediatric nephrology T32 training grant positions available to train fellows. Given current financial difficulties, it has also been difficult for Medical Schools and Departments of Pediatrics to commit resources to training fellows to do research. Taken together, there are often inadequate resources and few mentors available to train pediatric nephrologists to do basic, translational, or clinical research. The resulting paucity of pediatric nephrology fellows that develop successful careers in research dramatically impedes progress in deciphering pathophysiology and ultimately treatments for kidney diseases that affect children. The objective of this program is to train Pediatric Nephrology fellows to become clinician researchers. There will be four positions, two for PGY5 and two for PGY6 Pediatric Nephrology medical fellows. Fellows will be selected during their PGY4 year and with the guidance of the Program Director and Executive Committee, they will select a research mentor and convene a Mentoring Committee. The fellows will then participate in the program during their PGY5 and 6 years. This training program is uniquely positioned in that there are four (soon to be five) NIH-funded Pediatric Nephrology faculty members in this division (three of which are qualified to be trainers). This is also one of the largest Pediatric Nephrology divisions in the country with seven (soon to be eight faculty) with a robust clinical program that will enhance fellow recruitment. There is also an extreme wealth of high quality, NIH funded kidney/urinary tract research beyond our division at the University of Pittsburgh, including investigators in the College of Medicine and the College of Public Health. Moreover, the University of Pittsburgh ranks 5th in NIH awards obtained from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), much of which is in areas of kidney and urinary tract diseases. All of the faculty trainers in this program also have a significant track record of mentoring pre and post-doctoral trainees. The research areas are very diverse and include trainers focused on basic, translational, and clinical research. The environment is also very supportive and includes coursework and even optional degrees for fellows (e.g. Fundamentals of Biomedical Science courses for basic science and Certificate in Clinical Research, Masters in Clinical Research, or Masters of Public Health for clinical/translational science). The training program is also very focused on increasing the diversity of trainees and on education regarding the responsible conduct of research. In summary, the breadth of the research opportunities, training track record, and outstanding environment make this institution an excellent place to train research based Pediatric Nephrology fellows. PUBLIC HEALTH RELEVANCE: Pediatric nephrology describes the field of medicine that cares for children with kidney diseases. There are very few pediatric nephrologists that have been trained to do research into the causes of kidney disease in children; thus, this decreases the chances of quickly finding cures for kidney diseases in children. The purpose of this program is to train more pediatric nephrology doctors to do research on the causes of kidney disease in children.