Research Training in Pediatric Nephrology

描述（由申请人提供）：本申请旨在获得NIH资助，以培训匹兹堡大学/匹兹堡儿童医院（CHP）的儿科肾病学研究员，使其成为成功的临床科学家。目前，只有不到5%的美国儿科肾病学会成员拥有活跃的R01资助，而且很少有部门拥有超过一到两名NIH资助的儿科肾病学家。此外，很少有专门的儿科肾脏病T32培训资助职位可用于培训研究员。鉴于目前的财政困难，医学院和儿科部门也很难投入资源来培训研究员进行研究。综上所述，通常缺乏足够的资源和导师来培训儿科肾病学家进行基础、转化或临床研究。因此，在研究领域取得成功的儿科肾病学研究员的缺乏，极大地阻碍了对影响儿童肾脏疾病的病理生理学和最终治疗方法的解读。这个项目的目标是培养儿科肾脏病研究员成为临床研究人员。将有4个职位，2个为PGY5, 2个为PGY6儿科肾病医学研究员。研究员将在他们的PGY4年期间被选中，在项目主任和执行委员会的指导下，他们将选择一名研究导师并召集一个指导委员会。然后，研究员将在他们的PGY5和6年期间参加该计划。该培训项目的独特之处在于，该部门有四名（即将达到五名）美国国立卫生研究院资助的儿科肾脏病学教员（其中三名有资格成为培训师）。这也是全国最大的儿科肾脏病科之一，拥有7名（很快将达到8名）教师，有一个强大的临床项目，将加强同事招聘。除了我们匹兹堡大学的部门外，还有大量高质量的NIH资助的肾脏/泌尿道研究，包括医学院和公共卫生学院的研究人员。此外，匹兹堡大学在美国国立糖尿病、消化和肾脏疾病研究所（NIDDK）获得的NIH奖项中排名第五，其中大部分是在肾脏和泌尿系统疾病领域。在这个项目中，所有的教师培训师都有指导博士后和博士生的重要记录。研究领域非常多样化，包括专注于基础研究、转化研究和临床研究的培训师。环境也非常支持，包括课程，甚至为研究员提供可选学位（例如，基础科学的生物医学科学基础课程和临床研究证书，临床研究硕士或临床/转化科学的公共卫生硕士）。培训计划也非常注重增加受训者的多样性，以及关于负责任的研究行为的教育。总之，广泛的研究机会，良好的培训记录和良好的环境使该机构成为培养研究型儿科肾病研究员的绝佳场所。

DESCRIPTION (provided by applicant): This application seeks to obtain NIH funding to train pediatric nephrology fellows at the University of Pittsburgh/Children's Hospital of Pittsburgh (CHP) to become successful clinician scientists. Presently fewer than 5% of the membership of the American Society of Pediatric Nephrology have active R01 grants and few Divisions have more than one or two NIH funded Pediatric Nephrologists. Furthermore, there are few dedicated pediatric nephrology T32 training grant positions available to train fellows. Given current financial difficulties, it has also been difficult for Medical Schools and Departments of Pediatrics to commit resources to training fellows to do research. Taken together, there are often inadequate resources and few mentors available to train pediatric nephrologists to do basic, translational, or clinical research. The resulting paucity of pediatric nephrology fellows that develop successful careers in research dramatically impedes progress in deciphering pathophysiology and ultimately treatments for kidney diseases that affect children. The objective of this program is to train Pediatric Nephrology fellows to become clinician researchers. There will be four positions, two for PGY5 and two for PGY6 Pediatric Nephrology medical fellows. Fellows will be selected during their PGY4 year and with the guidance of the Program Director and Executive Committee, they will select a research mentor and convene a Mentoring Committee. The fellows will then participate in the program during their PGY5 and 6 years. This training program is uniquely positioned in that there are four (soon to be five) NIH-funded Pediatric Nephrology faculty members in this division (three of which are qualified to be trainers). This is also one of the largest Pediatric Nephrology divisions in the country with seven (soon to be eight faculty) with a robust clinical program that will enhance fellow recruitment. There is also an extreme wealth of high quality, NIH funded kidney/urinary tract research beyond our division at the University of Pittsburgh, including investigators in the College of Medicine and the College of Public Health. Moreover, the University of Pittsburgh ranks 5th in NIH awards obtained from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), much of which is in areas of kidney and urinary tract diseases. All of the faculty trainers in this program also have a significant track record of mentoring pre and post-doctoral trainees. The research areas are very diverse and include trainers focused on basic, translational, and clinical research. The environment is also very supportive and includes coursework and even optional degrees for fellows (e.g. Fundamentals of Biomedical Science courses for basic science and Certificate in Clinical Research, Masters in Clinical Research, or Masters of Public Health for clinical/translational science). The training program is also very focused on increasing the diversity of trainees and on education regarding the responsible conduct of research. In summary, the breadth of the research opportunities, training track record, and outstanding environment make this institution an excellent place to train research based Pediatric Nephrology fellows. PUBLIC HEALTH RELEVANCE: Pediatric nephrology describes the field of medicine that cares for children with kidney diseases. There are very few pediatric nephrologists that have been trained to do research into the causes of kidney disease in children; thus, this decreases the chances of quickly finding cures for kidney diseases in children. The purpose of this program is to train more pediatric nephrology doctors to do research on the causes of kidney disease in children.