MIT Center for Integrative Synthetic Biology

麻省理工学院综合合成生物学中心将通过整合系统生物学和合成生物学来创造未来的治疗学。系统生物学、合成生物学和健康相关应用的基础研究是在过去十年中蓬勃发展的三个主要学科。这些领域推动了生物医学科学的前沿，开发了用于生成和分析系统级数据的高通量平台，具有前所未有的生物系统工程能力，并在我们对人类疾病潜在的分子机制的理解方面取得了重大进展。然而，由于每个学科需要不同的专业知识，这些工作在很大程度上是相互独立的。因此，在一个研究中心集成系统生物学、合成生物学和与健康相关的应用是一个重要的机会。 我们麻省理工学院的核心研究小组准备与麻省理工学院综合合成生物学中心一起努力克服这些挑战。拟议中的中心的一个主要特点是我们专注于下一代治疗学的跨学科和协作研究。我们的主要疾病相关目标围绕癌症、糖尿病和传染病。系统生物学和合成生物学将共同促进与健康相关的应用领域的重大进步。通过将自上而下的系统疾病观点与自下而上的新疗法的综合构建相结合，这个社区将创造出具有整合多种投入和提供特定干预措施的能力的新疾病疗法。麻省理工学院综合合成生物学中心将在合成生物学、系统生物学和与健康相关的应用方面产生大量的协同效应，这是单靠独立研究人员领导的研究努力难以实现的。

The MIT Center for Integrative Synthetic Biology will create the therapeutics of the future by integrating systems biology and synthetic biology. Systems biology, synthetic biology, and fundamental research in health-related applications are three major disciplines that have thrived in the last decade. These fields have pushed the frontiers of biomedical science with the development of high-throughput platforms for generating and analyzing systems-level data, unprecedented abilities to engineer biological systems, and significant advances in our understanding of the molecular mechanisms underlying human disease. However, due to the diverse expertise required in each discipline, these efforts have been largely independent from each other. Therefore there is a significant opportunity for the integration of systems biology, synthetic biology, and health-related applications in a single research center. Our core group of researchers at MIT is poised to spearhead efforts to overcome these challenges with the MIT Center for Integrative Synthetic Biology. A key feature of the proposed Center is our focus on interdisciplinary and collaborative research into next-generation therapeutics. Our major disease-related targets revolve around Cancer, Diabetes, and Infectious Diseases. Together systems biology and synthetic biology will contribute to significant advances in health-related applications. By integrating top-down systems views of disease with bottom-up synthetic construction of novel treatments, this community will create new disease therapies with the ability to integrate multiple inputs and deliver specific interventions. Numerous synergies in synthetic biology, systems biology, and health-related applications will be generated by the MIT Center for Integrated Synthetic Biology which would be difficult to achieve via solely independent investigator-led research efforts.