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testing the effect of a DPP-4 inhibitor on immune function

testing the effect of a DPP-4 inhibitor on immune function
测试 DPP-4 抑制剂对免疫功能的影响
批准号：
9565923
负责人：
Kristin Tarbell
金额：
$7.12万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9565923
关键词：
AftercareAmino AcidsBeta CellBiological AssayBlood specimenCXCL10 geneCell physiologyCleaved cellClinical TrialsDiseaseDouble-Blind MethodImmune responseImmune systemIndividualInstitutesInsulinInsulin-Dependent Diabetes MellitusLengthMeasuresNon-Insulin-Dependent Diabetes MellitusPancreasPatientsPlacebosRandomizedRoleTestingToxic effectchemokineglucagon-like peptide 1healthy volunteerimmune functionimmunoregulationimprovedin vivoinhibitor/antagonistinteresttime interval

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中文摘要
翻译
DPP4可以从一些趋化因子的末端切割2个氨基酸，使趋化因子失去活性。巴斯德研究所的合作者对抑制DPP4对活性趋化因子形式水平的影响很感兴趣。
英文摘要
DPP4 can cleave 2 amino acids off the end of a number of chemokines, rendering the chemokine inactive. Collaborators at the Pasteur institute were interested in what effect inhibiting DPP4 would have on the level of the active chemokine forms. Using a new assay developed by our collaborators, the level of full-length (active form) and cleaved (inactive) CXCL10 were measured in healthy individuals before and after administration of either sitagliptin or placebo. During active DPP4 inhibition while taking sitagliptin, individuals showed a decrease in full length CXCL10 and an increase in the shorter inactive form. Therefore, DPP4 has a dominant role for processing CXCL10 in vivo.
期刊论文(2)
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会议论文
Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies.
DOI： 10.15252/emmm.201506145
发表时间： 2016-06
期刊： EMBO molecular medicine
影响因子： 11.1
作者： [Decalf J, Tarbell KV, Casrouge A, Price JD, Linder G, Mottez E, Sultanik P, Mallet V, Pol S, Duffy D, Albert ML]
通讯作者： Albert ML
dendrtitic cell subsets in autoimmune diabetes
Dendritic cell subsets in autoimmune diabetes
testing the effect of a DPP-4 inhibitor on immune function
Dendritic cell subsets in autoimmune diabetes
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