Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

用于流动啮齿动物测量左心室压力和容量的无线系统

• 批准号: 9255972
• 负责人: Timothy H. Riehle
• 金额: $ 22.5万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9255972
• 关键词: Adverse drug effect; Anesthesia procedures; Animal Testing; Animals; Biomedical Technology; Blood; Blood Volume; Canada; Cardiac; Cardiovascular system; Catheters; Chest; Chronic; Complex; Conscious; Data; Development; Devices; Frequencies; Goals; Health Sciences; Heart; Heart Diseases; Implant; Left; Left ventricular structure; London; Market Research; Measurement; Measures; Medical; Medical Research; Medicine; Methods; Modeling; Monitor; Mus; Muscle; Myocardial; Myocardial Infarction; Myocardium; Pathway interactions; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Physiologic intraventricular pressure; Property; Rattus; Research; Research Personnel; Research Support; Rodent; Rodent Model; Rofecoxib; Safety; Scientist; Sedation procedure; Senior Scientist; Signal Transduction; Small Business Innovation Research Grant; Stroke Volume; System; Techniques; Technology; Telemetry; Texas; Time; Transgenic Model; Two-Dimensional Echocardiography; Universities; Ventricular Function; Wireless Technology; base; commercialization; design; electric impedance; experience; heart pharmacology; implantable device; light weight; monitoring device; novel; novel therapeutics; pressure; product development; professor; prototype; research clinical testing; screening; skills

Abstract In this Phase I SBIR, Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume (P-V) in rodent studies. Transgenic models of heart disease have been created through hypothesis-driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the development of novel compounds and medications by large pharmaceutical companies. As a result, it has become increasingly important to accurately and thoroughly evaluate cardiac function in the mouse and rat model. Although implanted telemetric pressure systems have been successfully commercialized for both mice and rats, a device that also measures real-time volume in a free-roaming rodent has been absent to date. The proposed miniature, lightweight, fully implanted device will collect pressure and volume measurements using an admittance measurement technique and wirelessly transmit the measured data to a nearby base station.

摘要 在第一阶段SBIR中，Koronis生物医学技术公司建议开发和评估一种全面的 在啮齿动物研究中监测左心室压力和容积（P-V）的植入式无线设备。 心脏病的转基因模型已经通过对啮齿动物的假设驱动的研究创建， 旨在确定学术研究中的机制途径，并支持新的 大型制药公司的化合物和药物。因此，它变得越来越 这对于在小鼠和大鼠模型中准确和彻底地评估心脏功能是重要的。虽然 植入式遥测压力系统已成功商业化用于小鼠和大鼠， 到目前为止，还没有一种设备可以测量自由漫游的啮齿动物的实时音量。的 所提出的微型、轻量、完全植入的装置将收集压力和体积测量值 并将测量数据无线传输到附近的基站 站