Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

用于流动啮齿动物测量左心室压力和容量的无线系统

• 批准号: 10002118
• 负责人: Timothy H. Riehle
• 金额: $ 70.76万
• 依托单位: KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002118
• 关键词: Adverse drug effect; Algorithms; Anesthesia procedures; Animal Testing; Animals; Biomedical Technology; Blood; Blood Volume; Cardiac; Cardiovascular system; Catheters; Chest; Chronic; Complex; Computer software; Conscious; Data; Data Analyses; Development; Devices; Frequencies; Goals; Health Sciences; Heart; Heart Diseases; Implant; Left; Left ventricular structure; Market Research; Measurement; Measures; Medical; Medical Research; Medicine; Methods; Modeling; Monitor; Mus; Muscle; Myocardial; Myocardial Infarction; Myocardium; Pathway interactions; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Physiologic intraventricular pressure; Principal Investigator; Property; Rattus; Real-Time Systems; Research; Research Personnel; Research Support; Rodent; Rodent Model; Rofecoxib; Scientist; Sedation procedure; Signal Transduction; Small Business Innovation Research Grant; Stroke Volume; System; Systems Analysis; Techniques; Technology; Telemetry; Texas; Time; Transgenic Model; Two-Dimensional Echocardiography; Universities; Ventricular Function; Wireless Technology; base; commercialization; data acquisition; data quality; design; drug efficacy; electric impedance; experience; heart function; heart pharmacology; hemodynamics; implantable device; improved; light weight; medication safety; miniaturize; monitoring device; novel; novel therapeutics; pressure; product development; professor; prototype; research clinical testing; screening; skills

Abstract In this Phase II SBIR, Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume (P-V) in rodent studies. Transgenic models of heart disease have been created through hypothesis-driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the development of novel compounds and medications by large pharmaceutical companies. As a result, it has become increasingly important to accurately and thoroughly evaluate cardiac function in the mouse and rat model. Although implanted telemetric pressure systems have been successfully commercialized for both mice and rats, a device that also measures real-time volume in a free-roaming rodent has been absent to date. The proposed miniature, lightweight, fully implanted device will collect pressure and volume measurements using an admittance measurement technique and wirelessly transmit the measured data to a nearby base station.

摘要 在这个第二阶段的SBIR中，Koronis Biomedical Technologies公司提议开发和评估一种完全可植入的 在啮齿动物研究中监测左心室压力和容量(P-V)的无线设备。转基因模型 是通过对啮齿动物进行的假说驱动的研究产生的，该研究试图识别出 学术研究中的机械途径，并支持新化合物和 大型制药公司的药物。因此，它变得越来越重要 在小鼠和大鼠模型中准确和彻底地评估心脏功能。尽管植入遥测仪器 压力系统已经成功地商业化，用于小鼠和大鼠，这种设备还可以测量 自由漫游的啮齿动物到目前为止还没有实时音量。拟议的微型、轻便、完全 植入的装置将使用导纳测量技术收集压力和体积测量 并将测量数据无线传输到附近的基站。