Neurocognitive Training to Improve Executive Function

神经认知训练以改善执行功能

基本信息

项目摘要

DESCRIPTION (provided by applicant): In this Phase I STTR project Koronis Biomedical Technologies (KBT) in close collaboration with the Zelazo Lab at the University of Minnesota proposes to develop an electroencephalography (EEG) based neurocognitive training tool to enable individuals to improve neurocognitive processes associated with executive function (EF). Processes involved in self-control and goal-directed problem solving referred to as Executive Function play an instrumental role in learning and comprise a key protective system for academic resilience in high-risk children. Shortcomings in Executive Function have a higher prevalence in low social economic status children and are correlated to higher rates of incarceration, substance abuse, and lower academic performance. Neurocognitive training is a form of biofeedback in which real-time measures of brainwave activity are presented to the individual to enable them to willfully control their current mental state. Gamma states (EEG activity above 30Hz) in addition to Beta wavelengths will be detected on the frontal scalp and used to drive custom hardware to provide instantaneous feedback through an innovative mode of action. It is hypothesized that high frequency activity in the prefrontal area is associated with processes implicated in executive function. Advantages of the proposed product when compared to existing commercial EEG-based feedback devices on the market are the following: Executive Function (EF) is the target which has not been the case previously; feedback mode of action is independent of video games and video consoles; device can be used during reading, listening and real-world activities that should greatly improve generalizability and sustainability of improvements to real-world skills and behaviors; improvements in EF will be confirmed with standardized assessments from NIH toolbox and other validated peer-reviewed measures as opposed to subjective parent/teacher ratings. The feasibility of the system will be evaluated in this Phase I project by pursuing four specific aims: 1) Construct a prototype EEG neurocognitive training system for Executive Function improvement; 2) Develop a neurocognitive training regimen consisting of a program of diverse and engaging activities for children and young adolescents; 3) Conduct a pilot human study to assess whether it is possible to increase relative gamma power and other wavelengths over the frontal scalp using EEG neurocognitive training; and 4) use the NIH Toolbox Cognition measures to assess whether improvements are seen in behavior (esp. EF), and whether they are correlated with increases in gamma power or other wavelength patterns. The results from this Phase I project will be used to design a portable prototype to evaluate in clinical studies and to validate and verify requirements of a refined product design for the clinical, school and learning center markets to improve executive function in children. PUBLIC HEALTH RELEVANCE: Neurocognitive processes involved in self-control and goal-directed problem solving referred to as executive function play an instrumental role in learning and comprise a key protective system for resilience in high-risk children. Neurofeedback based on electroencephalography signatures correlated with these neurocognitive processes may provide powerful tools to aid in the development of these cognitive processes and the managing of healthy behaviors. Shortcomings in executive function are characteristic of children with a variety of disorders (e.g., ADHD, Conduct Disorder, autism) and are correlated with higher rates of incarceration, substance abuse, and lower academic performance.
描述(由申请人提供):在这个第一阶段STTR项目中,Koronis生物医学技术公司(KBT)与明尼苏达大学Zelazo实验室密切合作,提出开发一种基于脑电图(EEG)的神经认知训练工具,使个人能够改善与执行功能(EF)相关的神经认知过程。涉及自我控制和目标导向问题解决的过程被称为执行功能,在学习中起着重要作用,并构成了高风险儿童学业恢复能力的关键保护系统。执行功能缺陷在社会经济地位较低的儿童中更为普遍,并且与较高的监禁率、药物滥用率和较低的学习成绩有关。神经认知训练是一种生物反馈的形式,在这种形式中,脑电波活动的实时测量被呈现给个体,使他们能够有意识地控制自己当前的精神状态。除了Beta波长外,伽玛状态(超过30Hz的脑电图活动)也会在前额头皮上被检测到,并用于驱动定制硬件,通过创新的行动模式提供即时反馈。据推测,前额叶区域的高频活动与涉及执行功能的过程有关。与市场上现有的基于脑电图的商业反馈设备相比,拟议产品的优势如下:执行功能(EF)是以前没有的目标;反馈行为模式独立于电子游戏和游戏机;设备可以在阅读,听力和现实世界的活动中使用,这应该大大提高现实世界技能和行为改进的普遍性和可持续性;EF的改善将通过NIH工具箱的标准化评估和其他有效的同行评议措施来确认,而不是主观的家长/老师评分。本一期项目将从四个方面对系统的可行性进行评估:1)构建一个用于执行功能改善的原型EEG神经认知训练系统;2)为儿童和青少年制定一个神经认知训练方案,包括一个多样化和引人入胜的活动方案;3)开展人体先导研究,评估是否有可能利用脑电图神经认知训练增加额叶头皮的相对伽马功率和其他波长;4)使用NIH工具箱认知测量来评估行为(尤其是EF)是否有所改善,以及它们是否与伽马功率或其他波长模式的增加相关。第一阶段项目的结果将用于设计便携式原型,以评估临床研究,并验证和验证临床,学校和学习中心市场的改进产品设计的需求,以改善儿童的执行功能。

项目成果

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Timothy H. Riehle其他文献

Timothy H. Riehle的其他文献

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{{ truncateString('Timothy H. Riehle', 18)}}的其他基金

Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle
用于流动啮齿动物测量左心室压力和容量的无线系统
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  • 财政年份:
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    $ 18.07万
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用于流动啮齿动物测量左心室压力和容量的无线系统
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    2017
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    $ 18.07万
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Point of Care Tracheostomy Tube Patency Monitor using an Ultrasonic Flow Sensor
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    8839595
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    2014
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    $ 18.07万
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Cognitive Training for ADHD Treatment using a Gaming Model
使用游戏模型进行多动症治疗的认知训练
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    8715059
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    2014
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    $ 18.07万
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Monitoring Outside the Home of Older Adults at Risk for Sudden Cardiac Death
对有心源性猝死风险的老年人进行户外监测
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    $ 18.07万
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Ultra-Miniature Dosimeter with Magnetic Localization
具有磁定位功能的超小型剂量计
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    $ 18.07万
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Blind Navigation Using Magnetic Anomaly Detection Augmented with Inertial Sensors
使用惯性传感器增强的磁异常检测进行盲导航
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    2010
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    $ 18.07万
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Magnetic Location System For Catheter Guidance
用于导管引导的磁性定位系统
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    2009
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    $ 18.07万
  • 项目类别:
Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
用于超薄支气管镜导航的薄膜磁传感器
  • 批准号:
    7656572
  • 财政年份:
    2006
  • 资助金额:
    $ 18.07万
  • 项目类别:
Thin Film Magnetic Sensors for Ultrathin Bronchoscope Navigation
用于超薄支气管镜导航的薄膜磁传感器
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    7481722
  • 财政年份:
    2006
  • 资助金额:
    $ 18.07万
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